Avsnitt
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Glenn King discusses his research in epilepsy and how animal venoms can be utilised to develop new treatments! He explains the mechanisms of ion channels, the diversity of venoms, and the process of identifying effective compounds. The conversation also touches on the challenges of drug development, the potential for personalised medicine, and the future of epilepsy treatment..
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๐ Website & more about Glenn ๐๐ป
www.torierobinson.com/epilepsy-sparks-insights/glenn-king-treating-epilepsy-with-spider-venom
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Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป
https://www.epilepsysparks.com/glossary
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Paediatric neurologist Eleni Panagiotakaki discusses her work in paediatric epileptology, focusing on rare epilepsies such as Alternating Hemiplegia of Childhood (AHC) and GRIN disorders. She highlights the challenges in diagnosing and treating these conditions, the variability of symptoms, the importance of a holistic approach to care, and the role of parents in driving research!
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๐ Website & more about Eleni ๐
https://www.torierobinson.com/epilepsy-sparks-insights/eleni-panagiotakaki-ahc-grin-genetic
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Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐ https://www.epilepsysparks.com/glossary
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Saknas det avsnitt?
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What are Acute Symptomatic Seizures, how do they differ from epileptic seizures, and how can one recover? Who will develop an epilepsy after one and what are the causes?! Think stroke, TBI, tumours, infection, encephalitis, status epilepticus...! Find out all about it from neurocritical care and epileptology specialist neurologist Clio Rubinos.
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Website, transcript, & more about Clio: ๐๐ป
https://www.torierobinson.com/epilepsy-sparks-insights/clio-rubinos-acute-symptomatic-seizures
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Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป https://www.epilepsysparks.com/glossary
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Post-doc researcher Zelekha Seedat discusses her work as a postdoctoral researcher at Young Epilepsy, focusing on Magnetoencephalography (MEG) and the innovative Optically Pumped Magnetometers (OPM) technology. She explains the differences between MEG and EEG, the advantages of OPM technology, and the challenges faced in interpreting data. The conversation also covers the importance of combining EEG with OPM-MEG for better data accuracy, the future potential of OPM-MEG in clinical settings, and how to get involved in her research!
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๐ Website & more about Zelekha ๐๐ป
https://www.torierobinson.com/epilepsy-sparks-insights/zelekha-seedat-opm-meg-young-epilepsy
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Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป https://www.epilepsysparks.com/glossary
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Post-doc researcher Christine Embury shares with us her research on the cool OPM-MEG technology for brain imaging - its advantages (particularly for children with refractory epilepsy and considering brain surgery!) and how it could improve patient outcomes and our understanding of developmental trajectories in paediatric epilepsies! Lastly, Christine and Torie chat about the cost-effectiveness of the device, its benefits from an energy usage/climate change perspective, and how both patients and clinicians can get involved in the research!
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๐ Transcript & more about Christine ๐๐ป
https://www.torierobinson.com/epilepsy-sparks-insights/christine-embury-opm-meg-young-epilepsy
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Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐ https://www.epilepsysparks.com/glossary
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Reza Shervin-Badv, a paediatric epileptologist and neurologist talks about the diverse care available for people in Iran, plus the common epilepsy stigma which is being challenged through education and advances in medical care.
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๐ Website & more about Reza: ๐๐ป
https://www.torierobinson.com/epilepsy-sparks-insights/reza-shervin-badv-iran-epilepsy-stigma
______________
Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป https://www.epilepsysparks.com/glossary
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Find out about a new epilepsy discovery; how the microRNA-335 molecule impacts people with both Dravet Syndrome and Temporal Lobe Epilepsy, and what this could mean for research going forward! All with post-doc researcher Mona Heiland!
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๐ Website & more about Mona: ๐๐ป
https://www.torierobinson.com/epilepsy-sparks-insights/mona-heiland-newly-discovered-molecule-microrna-335
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Chapters ๐
00:00 Trailer & Intro
00:45 Meet Mona
01:07 Explaining Sodium Channel Epilepsies
06:03 Understanding MicroRNAs and Their Role in Epilepsy
07:47 Research Findings on MicroRNA-335 and Sodium Channels
10:01 Future Directions in Precision Therapies for Epilepsy
11:18 Conclusion & thanks
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Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป https://www.epilepsysparks.com/glossary
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Physicist Sjoerd Vos shares his research in neuroimaging; aiming at decreasing language decline caused by temporal lobe resections!
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๐ Website & more about Sjoerd
https://www.torierobinson.com/epilepsy-sparks-insights/sjoerd-vos-physics-mri-temporal-lobe-epilepsy-resection-cognitive
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Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐ https://www.epilepsysparks.com/glossary
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๐ฒ Join me on social media!
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Eduardo Pรฉrez Palma, a neurogenetics scientist and bioinformatician, discusses his work in neurogenetics and epilepsy research, emphasising the importance global collaboration in studying the epilepsies in different parts of the world! Eduardo also shares the upcoming Latin American Congress on Genetic Epilepsiesin Jan 2025; which aims to bring together experts from various fields to share knowledge and perspectives!
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๐ Website & more about Eduardo: ๐๐ป
https://www.torierobinson.com/epilepsy-sparks-insights/eduardo-perez-palma-neurogenetics-dee-latin-america
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Chapters ๐
- Intro to Eduardo
- The Value of Genetic Testing in Epilepsy
- Diversity and Representation in Genetic Research
- Understanding Developmental Epileptic Encephalopathies (DEEs)
- Contributing to Epilepsy Research
- Latin American Congress on Epileptsy Genetics
- Conclusion & thanks
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Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป https://www.epilepsysparks.com/glossary
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#genetics #neurogenetics #exomesequencing #epilepsy
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Learn of exciting research into a drug screening platform for personalised medicine for the epilepsies - through adult neurologist and researcher Patrick Kwan; head of the Kwan Lab! Patrick describes the process of extracting stem cells from blood, culturing them, and using them to develop new treatments for drug-resistant epilepsy. The conversation highlights the importance of collaboration and data sharing in epilepsy research.
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๐ Website & more about Patrick๐
https://www.torierobinson.com/epilepsy-sparks-insights/patrick-kwan-advances-stem-cell-research-epilepsy
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Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐ https://www.epilepsysparks.com/glossary
------------------------------------------
๐ฒ Join me on social media!
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People with an epilepsy might be nervous about getting "gene therapy" - but in today's mini-episode, in part 2 of 2, epileptologist Josรฉ M Serratosa is asked if he would get gene therapy and why(!), explains the use of viral vectors for treating genetic epilepsies, where we are in preclinical development, what is next, and what is also holding us back!
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๐ Transcription & more about Josรฉ: ๐๐ป
https://www.torierobinson.com/epilepsy-sparks-insights/jose-m-serratosa-gene-therapies-viral-vectors
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Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป https://www.epilepsysparks.com/glossary
------------------------------------------
๐ฒ Join me on social media!
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#epilepsy #genetherapy #genetics #vectors #viralvectors #lafora
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What does the future for epilepsy treatments hold?! Epileptologist Josรฉ M Serratosa shares his predictions for epilepsy gene therapies; highlighting the importance of addressing all symptoms - including cognitive, motor, and psychiatric - as well as the seizures. Jose explains the role of viral vectors and how they may save people! This is part 1 of 2 with Josรฉ - in part 2, the conversation goes into the challenges of research clinical trials for these therapies; from basic, to pre-clinical, to clinical!
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๐ Transcription & more about Josรฉ: ๐๐ป
https://www.torierobinson.com/epilepsy-sparks-insights/jose-m-serratosa-future-epilepsy-gene-therapies
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Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป https://www.epilepsysparks.com/glossary
------------------------------------------
๐ฒ Join me on social media!
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#epilepsy #genetherapy #genetics #vectors #viralvectors #lafora
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Michael Sperling, a prof of neurology and director of the Jefferson Comprehensive Epilepsy Center, educates us on laser ablation therapy for epilepsy! He and Torie discuss the minimally invasive nature of the procedure, its advantages over traditional open surgery, and its efficacy in reducing seizures. They also touch on the suitability of the therapy for different age groups and types of epilepsy. The conversation highlights the precision and safety of laser ablation therapy and its potential to improve outcomes for patients.
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Michaelโs related papers ๐
https://www.researchgate.net/profile/Michael-Sperling-2
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Who knows about Acute Symptomatic Seizures and how the babies and children experiencing them can be carefully weaned off of the anti-seizure medications they are on? Paediatric neurologist and epilepsy specialist Maria Gogou from University General Hospital of Alexandroupolis, Greece, explains more. Paediatric neurologist and epilepsy specialist Maria Gogou from University General Hospital of Alexandroupolis, Greece, explains more.
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๐ Website & more about Maria ๐
https://www.torierobinson.com/epilepsy-sparks-insights/maria-gogou-acute-symptomatic-seizures-weaning-babies-asms
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Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐ https://www.epilepsysparks.com/glossary
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Children may benefit from being weaned off of anti-seizure medications when they are on the ketogenic diet. Plus, find out how the ketogenic diet can significantly benefit children with epilepsy - even when it doesnโt control their seizures! Paediatric neurologist Maria Gogou discusses her work in managing rare and complex epilepsies in children.
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๐ Paper: โAntiseizure medication reduction and withdrawal in children with drug-resistant epilepsy after starting the ketogenic dietโ ๐
https://onlinelibrary.wiley.com/doi/full/10.1111/dmcn.15377
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๐ Website, transcription, & more about Maria ๐
https://www.torierobinson.com/epilepsy-sparks-insights/maria-gogou-staying-on-a-keto-diet-that-doesnt-work-dravet
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Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐https://www.epilepsysparks.com/glossary
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David Henshall shares how information gathered when researching worms led to the discovery of microRNA, a far improved understanding of the epilepsies, and potential treatments - all explained in his new book (link below)! This is episode 2 of 2.
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Davidโs book ๐
https://www.amazon.co.uk/Fine-Tuning-Life-MicroRNAs-Genomes-Regulators/dp/1009466429/ref=sr_1_1
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๐ Website & more about David: ๐๐ป
https://www.torierobinson.com/epilepsy-sparks-insights/david-henshall-micro-rna-epilepsy
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Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป
https://www.epilepsysparks.com/glossary
------------------------------------------
๐ฒ Join me on social media!
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#epilepsy #mrna #genetics #geneticepilepsy #DavidHenshall
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David Henshall discusses the role and importance the role of microRNAs in epilepsy; which act as master regulators of gene activity and help stabilise the gene pathway. He discusses the potential of RNA therapy in treating epilepsy and the challenges of delivering RNA molecules to the brain. Henshall's book, 'Fine Tuning Life: A Guide to MicroRNAs, Your Genome's Master Regulators,' explores the fascinating world of microRNAs and their impact on gene regulation.
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Davidโs book ๐
https://www.amazon.co.uk/Fine-Tuning-Life-MicroRNAs-Genomes-Regulators/dp/1009466429/ref=sr_1_1
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๐ Website & more about David: ๐๐ป
https://www.torierobinson.com/epilepsy-sparks-insights/david-henshall-fighting-epilepsy-with-micrornas
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Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป
https://www.epilepsysparks.com/glossary
------------------------------------------
๐ฒ Join me on social media!
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#epilepsy #mrna #genetics #geneticepilepsy #DavidHenshall
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Epileptologist Eddie Chengo from Kenya discusses the stigma faced by people affected by epilepsy in Africa, explaining that around 75% of people with epilepsy in the region experience stigma and emphasising the importance of addressing this whilst implementing medical treatment. Eddie also shares the various initiatives and research projects his organisation is undertaking to raise awareness and challenge the stigma associated with epilepsy.
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๐ Eddie's papers ๐
https://www.researchgate.net/scientific-contributions/Eddie-Chengo-44151310
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๐ Website & more about Eddie ๐
https://www.torierobinson.com/epilepsy-sparks-insights/eddie-chengo-epilepsy-stigma-kenya
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Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐ https://www.epilepsysparks.com/glossary
------------------------------------------
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#epilepsy #neurology #stigma #discrimination
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A mutation of a gene can lead to lack of absorption of glucose (our fuel) and cause epilepsy! Carla Marini, a paediatric neurologist and neuropsychiatrist tells us all about the rare epilepsy and metabolic disorder GLUT1 Deficiency Syndrome, emphasising the importance of early diagnosis, treatment using the ketogenic diet (which can help control seizures, improve cognitive function, and decrease the impacts of movement disorders). She also highlights the value of working closely with patient and family groups to understand the clinical manifestations and natural history of the disease. Carla shares an uplifting success story of a patient who has thrived with early intervention.
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Papers mentioned ๐
โGlucose Transporter 1 Deficiency as a Treatable Cause of Myoclonic Astatic Epilepsyโ:https://jamanetwork.com/journals/jamaneurology/fullarticle/1107863
โEarly onset absence epilepsy due to mutations in the glucose transporter GLUT1โ:https://www.researchgate.net/publication/26864996_Early_onset_absence_epilepsy_due_to_mutations_in_the_glucose_transporter_GLUT1
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๐ Website & more about Carla ๐
https://www.torierobinson.com/epilepsy-sparks-insights/carla-marini-glut1-disorder-metabolism-genetic
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Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐ https://www.epilepsysparks.com/glossary
------------------------------------------
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Neuroscientist Nazanin Azarinejad Mohammadi discusses her research on epilepsy genetics, the clinical and functional characterisation of GABAA-receptor related disorders, and how mutations in the GABAA-receptor subunits can lead to epilepsy and morbidities. Nazanin also highlights the variability in symptoms among individuals with the same mutation and the need for further research to understand the factors that contribute to this variability. Plus, emphasised is the importance of genetic testing and personalised treatment for patients with these mutations.
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Paper: โClinical and functional characterization of GABAA-receptor related disorders: translating genetic diagnostics into personalized treatmentโ ๐
https://portal.findresearcher.sdu.dk/en/publications/clinical-and-functional-characterization-of-gabaa-receptor-relate
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๐ Website & more about Nazanin ๐
https://www.torierobinson.com/epilepsy-sparks-insights/nazanin-azarinejad-mohammadi-genetic-testing-personalised-treatment-GABA-receptors
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Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐ https://www.epilepsysparks.com/glossary
-----------------------------------------
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- Visa fler
