Avsnitt
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Just about the hottest thing in longevity science right now is partial reprogramming - using Yamanaka factors to rewind the biological clock in our cells. Billion-dollar giants like Altos, Retro and New Limit are betting on it.
But in this episode a far smaller player, Shift Bioscience, argues that the field may be looking in the wrong place. CEO Daniel Ives explains how his team used AI-powered virtual cells to uncover a single gene that seems to match OSK-level rejuvenation without the tumor risk that haunts classical reprogramming - and why their just-released data could change the game for aging research.
🔍 In this conversation
✅ Daniel’s journey from mitochondrial PhD work to founding Shift Bioscience.
✅ Why Yamanaka-factor–based partial reprogramming excites the field and why it’s inherently risky.
✅ Epigenetic clocks 101 — Horvath, single-cell versions, and what they really measure.
✅ Building AI “virtual cells” (transformers / GNNs) to run millions of in-silico experiments.
✅ Discovery of new rejuvenation factor sets - including SB000, a lone gene that rejuvenates without inducing pluripotency.
✅ Early wet-lab validation across fibroblasts & keratinocytes; next-step mouse studies already under way.
✅ How inhibition targets (not just over-expression) could slash timelines from 15 years to ~5 years.
✅ Mapping a “risk landscape” of age-linked diseases and why fibrosis may be the fastest clinical entry point.
✅ Funding Shift: from personal redundancy money to a $16 M seed and the next raise.
✅ Timelines, escape-velocity hopes, and where cryonics still fits.
✅ What Daniel would ask Jeff Bezos, and why the pharma ecosystem needs to “plug in” now.
🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership
🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: reachlevity.com
🚀 LEVITY is co-hosted by Patrick Linden, philosopher and author, and Peter Ottsjö, journalist and author.
CHAPTERS
00:00 Introduction to Daniel Ives
05:34 The Evolution of Shift's Focus
13:25 Understanding Aging Clocks
19:28 Commercial Clocks is ”Mostly Entertainment”
21:03 A Pivotal Meeting with Steve Horvath
24:35 A Brief Crash Course in Yamanaka Factors
28:16 Finding Something Better Than Yamanaka Factors
33:20 The Origin Story For This Approach
36:50 What Does Shift’s New Results Show?
37:33 Defining the Virtual Cell in This Context
44:22 The Gene is Called SB000
46:45 “This Could be Hugely Important”
01:01:44 Speeding up Drug Development with AI
01:11:12 What do Investors Say?
01:17:15 What Daniel Hope Will Happen Next
01:19:34 What Would Daniel Ask of Jeff Bezos?
01:27:00 Why is the company called Shift?
01:32:55 The Pride Day for Closeted Aging Biologists
01:42:28 How Should We Think About Cryonics?
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We think that death is bad, but why exactly is it bad? We cannot suffer when we do not exist, so why would it be bad?
In this episode we have a long, deep conversation with Professor Travis Timmerman, whose philosophical work delves deeply into the nature and ethics of death. An Associate Professor at Seton Hall University, Professor Timmerman has become a prominent voice in contemporary discussions about whether death is bad for us, how we should understand the harm of dying, and what moral obligations we might have surrounding death and dying. His work engages both timeless questions and urgent contemporary debates—offering fresh insight into topics like the timing of death’s harms, the ethics of procreation, and our attitudes toward mortality.
What you'll learn in this episode:
✅ Why death is bad
✅ How it can bad to not have been born earlier
✅ What the ancient Mirror Argument gets wrong
✅ How it can be bad for a 95-year-old to die
✅ Whether we should wait to have children
✅ How an analytical philosopher thinks about death
🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership
🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: reachlevity.com
--CHAPTERS--
00:00 introduction
00:50 Why is death bad? The Deprivation account
15:30 Lucretius
18:10 A reason to live is a reason to see death as bad
20:20 James Stacey Taylor vs Travis Timmerman
26:20 Deprivation account and mercy killing
29:20 Counter intuitive implications of the Deprivation Account - overdetermination of death
37:20 What would have happened if I had not died? Possible worlds and the badness of death
40:40 The badness of a 95-year-old to die
47:00 Thomas Nagel - death and normalcy
51:49 Reasons and the good and the bad
53:40 The Timmerman style of analytic philosophy
01:00:49 Philosophers and prolongevity in history
01:08:28 Philosophy as therapy
01:09:40 Time and intrinsic good - what matters most?
01:14:36 Is health overrated?
01:16:27 The eternal philosophical dialogue
01:17:56 If longevity were impossible, how would that change philosophy of death?
01:21:35 The Mirror Argument
01:26:55 Could I have been born earlier?
01:39:22 When should we have children?
01:42:47 Better never to have been?
01:48:09 A world without consciousness
01:52:27 Can we wish for the impossible?
02:02:07 Meta-philosophy and ironing out the wrinkles of the Deprivation account
02:03:00 What Travis is working on
02:08:02 What what we should read
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Saknas det avsnitt?
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There were two reasons why Dr. Valter Longo was featured so prominently in my longevity book Evigt Ung (2022).
First, if you had to name a single scientific thread running through the history of longevity research, calorie restriction is hard to beat. And few have done more to modernize and translate that insight into real-world practice than Longo.
Second, I hold Valter Longo in the highest regard. I've tried his Fasting-Mimicking Diet (FMD), I’ve followed his work on The Longevity Diet, and I find his scientific contributions both rigorous and unusually translational. He doesn’t just publish papers - he builds systems, tests interventions in clinical trials, and tries to implement science into healthcare.
In this conversation, we cover the science, history, and application of fasting, nutrition, and longevity - including new work on cancer, metabolism, and organ regeneration. We also discuss the philosophical and political obstacles that stand in the way of real change.
What you'll learn in this episode:
✅ The story of Longo’s early music career - and why he left it to study aging.
✅ How calorie restriction shaped modern longevity science.
✅ Why Biosphere 2 and Roy Walford's work was both inspiring and cautionary.
✅ The origins and mechanisms of the Fasting-Mimicking Diet.
✅ What Longo learned about autophagy, stem cells, and organ regeneration.
✅ Why protein intake before and after age 65 should be treated differently.
✅ What the media and doctors get wrong about obesity, food, and metabolism.
✅ The dangers of high-protein and ketogenic diets.
✅ Why Longo is deeply skeptical of TRT, growth hormone, and biohacking shortcuts.
✅ How fasting can enhance cancer treatment - and why Longo wrote his new book Fasting Cancer.
✅ Why we need a new kind of “digital school” for lifestyle medicine.
🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership
🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: reachlevity.com
--CHAPTERS--
00:00 Introduction to Dr. Valter Longo
02:44 From Music to Aging Biology
06:40 The Supposed Longevity Zones of Italy
09:04 Personal Experiences Shaping Research
12:04 The Path to Aging Biology
13:15 Calorie Restriction and Roy Walford
26:25 Transitioning to Fasting Mimicking Diet Research
34:56 The Eureka Moment
39:51 The Rationale For the 5-Day FMD
52:54 The Un-conspired Conspiracy
01:01:18 Conflicts of Interest
01:04:52 Protein Intake: Balancing Muscle Health and Longevity
01:14:30 Autophagy: The Body's Self-Repair Mechanism
01:21:12 The Power of Genetic Variants in Longevity
01:27:18 The Debate on Growth Hormone and Aging
01:36:18 Insights from Laron Syndrome and Longevity
01:40:10 Fasting Mimicking Diet: A Path to Health
01:46:06 Valter's New Book, Fasting Cancer
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This is our first — and probably our last — episode where the guest has brought with him an actual punch card and proceeds to explain why it is, in fact, caca (which is Spanish for 💩, by the way).
Welcome to the wild world of José Cordeiro. Stick around and you might hear anecdotes about Robert Kennedy Jr. in Memphis 🎸, late-night karaoke sessions 🎤, and a man shouting “immortality!” to anyone and everyone. But behind the eccentric props and the shameless self-promotion (José didn’t just bring punch cards — he also brought his books 📚, his merch 👔, and his signature Death of Death tie — to the point where we had to clarify we’re not actually sponsored), there’s a deadly serious mission: José wants to end aging and defeat death.
A futurist, MIT-trained engineer, and bestselling author, José Cordeiro argues that humanity is on the brink of longevity escape velocity 🚀 — the moment when medical advances will start adding more years to our lives than time takes away. In this episode, we explore his bold predictions, from reversing aging by 2045 to launching a global “war on aging.” We cover the science 🔬, the politics 🏛️, the money 💰, and the wild optimism driving the longevity movement — with cryonics ❄️, Martians 👽, and €10 immortality claims all making appearances.
This might be our strangest — and most fascinating — conversation yet. Buckle up.
-- IN THIS EPISODE YOU'LL LEARN ABOUT --
✅ Why longevity escape velocity may be closer than we think
✅ How AI will aid longevity
✅ Why technological optimism is rational
✅ How the Covid pandemic was a relatively minor pandemic
✅ How the concept of work will change
✅ What the future of energy may be
✅ A personal history of Marvin Minsky, Ray Kurzweil and José Cordeiro
✅ Where to meet Cordeiro and demonstrate against aging
✅ Why immortality is probable by 2045
🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership
🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: reachlevity.com
-- CHAPTERS --
00:00 Introduction
05:33 Cordeiro's struggle to end aging
12:28 Traveling the world to spread the word of The Death of Death
18:36 The small Covid Pandemic vs the huge aging pandemic
26:00 Scientific optimism
29:37 "Next time we meet we will be younger."
32:28 The concept of work through history
35:50 Exponentiality of progress - a personal history of computers
43:30 Kurzweil and Cordeiro mentored by Marvin Minsky
50:26 The future of energy
57:56 When will we reach LEV and what happens 2045?
01:03:00 Madrid as a Blue Zone
01:06:30 AI coming and helping with science
01:17:00 The amazing point of the human timeline we are on - biology can be immortal
01:19:50 We are mostly water - immortality for 10 Euros per year
01:22:40 Advanced bio engineering and disruption from outside
01:24:30 Zuckerberg to cure all diseases in this generation - billionaires to the rescue
01:28:40 Elon Musk will change his mind
01:29:34 Trump administration and visiting Elvis with RFK
01:36:40 The importance of campaigning for life - we need action now
01:47:22 Cryonics
01:51:56 Sing karaoke
01:53:00 What to read
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Lately, there's been growing pushback against the idea that AI will transform geroscience in the short term.
When Nobel laureate Demis Hassabis told 60 Minutes that AI could help cure every disease within 5–10 years, many in the longevity and biotech communities scoffed. Leading aging biologists called it wishful thinking - or outright fantasy.
They argue that we still lack crucial biological data to train AI models, and that experiments and clinical trials move too slowly to change the timeline.
Our guest in this episode, Professor Derya Unutmaz, knows these objections well. But he’s firmly on Team Hassabis.
In fact, Unutmaz goes even further. He says we won’t just cure diseases - we'll solve aging itself within the next 20 years.
And best of all, he offers a surprisingly detailed, concrete explanation of how it will happen:
building virtual cells, modeling entire biological systems *in silico*, and dramatically accelerating drug discovery — powered by next-generation AI reasoning engines.
🧬 In this wide-ranging conversation, we also cover:
✅ Why biological complexity is no longer an unsolvable barrier.
✅ How digital twins could revolutionize diagnosis and treatment.
✅ Why clinical trials as we know them may soon collapse.
✅ The accelerating timeline toward longevity escape velocity.
✅ How reasoning AIs (like GPT-4o, o1, DeepSeek) are changing scientific research.
✅ Whether AI creativity challenges the idea that only biological minds can create.
✅ Why AI will force a new culture of leisure, curiosity, and human flourishing.
✅ The existential stress that will come as AI outperforms human expertise.
✅ Why “Don’t die” is no longer a joke — it's real advice.
🎙️ Hosted - as always - by Peter Ottsjö (tech journalist and author of Evigt Ung) and Dr. Patrick Linden (philosopher and author of The Case Against Death).
🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership
🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: reachlevity.com
-- CHAPTERS --
00:00 Introduction to Derya Unutmaz
05:22 Derya’s work at Jackson Laboratory
09:37 The impact of AI on research
15:04 AI as a collaborative partner
20:50 The nature of creativity in AI
30:21 Predictions for the future of AI and humanity
37:46 The future of AI in medicine
44:35 The impact of AI on professional identity
47:45 Education in the age of AI
01:01:32 The ethics of AI development
01:14:46 Longevity and AI's role in accelerating science
01:20:55 Virtual cells and digital twins
01:29:02 Can we do it in silico all the way?
01:33:08 Derya and Patrick will both talk at Vitalist Bay
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Peter Fedichev is a visionary scientist, biotech entrepreneur, and physicist at the forefront of longevity research. With a background in theoretical physics, he has seamlessly merged cutting-edge science with real-world applications, making groundbreaking contributions to the fields of aging, biotechnology, and artificial intelligence in healthcare. As the co-founder and CEO of Gero, a pioneering biotech company, Fedichev is revolutionizing our understanding of biological aging, using AI-driven approaches to uncover ways to extend human lifespan and combat age-related diseases. His work has been featured in leading scientific journals, and his insights are shaping the future of personalized medicine and longevity science. Driven by a relentless curiosity and a passion for pushing the boundaries of human potential, Fedichev is not just studying aging - he’s working to redefine it.
🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership
🚀 Show notes for this episode is available here: https://reachlevity.com/p/age-reversal-will-never-work-a-controversial-take-from-a-physicist-5935af91034fd123
-- EPISODE HIGHLIGHTS --
✅ The founding of Gero
✅ The physics of aging
✅ Why age reversal will not work
✅ What SENS gets right
✅ What SENS gets wrong
✅ AI and the longevity industry
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In this episode of LEVITY, we speak with Laurence Ion, a tech entrepreneur whose experience with a rare genetic disease led him to tackle one of humanity's greatest challenges: aging.
Starting as a shy coder who 'couldn't talk to strangers,' Laurence has become a movement leader pioneering a bold new approach: creating specialized cities where extending human lifespan isn't just a goal - it's the future of humanity.
-- EPISODE HIGHLIGHTS --
✅ Laurence's personal journey with multiple hereditary exostoses and how it shaped his perspective on aging and mortality.
✅ The founding and evolution of VitaDAO, a decentralized science organization funding longevity research.
✅ How crypto-based communities are accelerating anti-aging research outside traditional funding models.
✅ The concept of special jurisdictions for medical innovation where regulatory frameworks can move at "warp speed".
✅ Viva City's vision to create physical communities and hubs focused on longevity.
✅ The $2 million recursive finder's fee for anyone who helps secure a location for the first major Viva City jurisdiction.
✅ How living in community environments like Zuzalu and Aevitas House naturally promotes healthier lifestyle choices.
✅ The Frontier Tower project - a 16-story "vertical village" designed for longevity-minded living.
✅ JellyfishDAO's mission to change cultural narratives around aging through film and media.
✅ The relationship between AI advancement and longevity research.
✅ How decentralized clinical trials could dramatically reduce the cost and time of bringing treatments to people.
✅ Real-world examples of companies already offering experimental longevity treatments in special jurisdictions.
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We have another amazing guest for this episode: Anders Sandberg is a visionary philosopher, futurist, and transhumanist thinker whose work pushes the boundaries of human potential and the future of intelligence. As a senior research fellow at Oxford University’s Future of Humanity Institute until its closing in 2024 Sandberg explores everything from cognitive enhancement and artificial intelligence to existential risks and space colonization. With a background in computational neuroscience, he bridges science and philosophy to tackle some of the most profound questions of our time: How can we expand our cognitive capacities? What are the ethical implications of radical life extension? Could we one day transcend biological limitations entirely? Known for his sharp intellect, playful curiosity, and fearless speculation, Sandberg challenges conventional wisdom, inviting us to imagine—and shape—a future where humanity thrives beyond its current constraints.
00:00 introduction
04:18 exersise & David Sinclair
06:10 Will we survive the century?
18:18 Who can we trust? Knowledge and humility
23:17 Nuclear armaggedon
39:51 Technology as a double-edged sword
44:30 Sandberg origin story
56:54 Computational neuroscience
01:00:30 Personal identity and neural simulation
01:05:24 Personal identity and reasons to want to continue living
01:09:39 The psychology of behind different philosophical intutions and judgments
01:17:48 Is death bad for Anders Sandberg?
01:25:00 Altruism and individual rights
01:31:29 Elon Musk says we must die for progress
01:35:10 Artificial Intelligence
01:55:08 AI civilization
01:02:07 Cryonics
02:04:00 Book recommendations
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In this in-depth conversation, Dr. Aubrey de Grey discusses his Robust Mouse Rejuvenation (RMR) studies at the LEV Foundation and why he believes we're close to achieving the crucial RMR milestone within just three years - a breakthrough that could transform aging research forever.
You'll also hear about:
His predictions for reaching Longevity Escape Velocity by the late 2030s
What he would change about Bryan Johnson's longevity algorithm
How reaching RMR could trigger a global "war on aging"
Why AI won't solve aging without proper experimental data
How Demis Hassabis is the smartest person Aubrey's ever met
His involvement in designing the XPRIZE Healthspan competition
His rebuttal to Mark Hamalainen's "replacement strategy" approach
The divide-and-conquer approach to aging and why it's superior
🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: https://peterottsjo.beehiiv.com/
-- CHAPTERS --
00:00 Introduction and Welcome
03:15 The Background to LEV Foundation and the Robust Mouse Rejuvenation Studies
12:05 The Robust Mouse Rejuvenation Studies
18:10 Latest Results from the Mouse Rejuvenation Experiments
25:42 Reaching RMR soon and LEV in 12-15 years
33:47 Healthspanners in public - lifespanners in private?
37:03 The Replacement Strategy Debate with Mark Hamalainen
45:40 The Very, Very Difficult Challenge of Gradually Replacing the Brain
54:46 Advanced bioengineering
57:34 The Debate with Peter Fedichev
01:11:57 Understanding Aging from an Evolutionary Perspective
01:17:05 Artificial Intelligence and Longevity Research
01:26:42 Is believing in AI hopium?
1:28:27 Aubrey’s Involvement in the XPRIZE Healthspan Competition
1:38:56 Special Economic Zones and Regulatory Challenges
1:47:27 What Aubrey would do with Bryan Johnson’s algorithm
1:50:49 What Excites Aubrey Most About the Future
1:51:57 Book Recommendations and Closing Thoughts
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Jamie Justice takes us inside the $101M XPRIZE Healthspan competition - one of the world's largest efforts to develop therapeutics that could reverse aging.
As Executive Vice President of XPRIZE Healthspan, Jamie reveals how teams must demonstrate they can restore muscle, cognitive, and immune function in older adults within just one year. The stakes? $81M for achieving a 20-year reversal of aging markers, with $71M and $61M prizes for lesser but still remarkable achievements.
Jamie shares her fascinating journey from studying crickets' lifespans in elementary school to leading groundbreaking aging research, including work on the TAME trial with metformin. She explains why they chose these specific biological systems to measure, how they'll determine success, and what kinds of interventions teams are exploring - from repurposed drugs to gene therapies.
We discuss:
* Why Peter Diamandis pushed for more ambitious goals
* How over 550 teams from 55 countries are approaching the challenge EDIT: Since we recorded this in late 2024 they've now reached over 600 teams.
* The role of biomarkers in measuring aging
* Why they chose to measure actual restoration rather than just preventing decline
* The challenges and opportunities in aging clinical trials
* Her vision for an integrated, multi-generational society that values aging populations
🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership
🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: https://peterottsjo.beehiiv.com/
CHAPTERS:
00:00 Introduction
03:00 background
21:30 XPRIZE sculpted by experience
25:20 Collaborating with the entrant teams
29:00 Why muscle, mind and immune functions as targets
36:30 What if no one wins in 7-years?
41:05 Investors attracted
45:01 Does this give us increased longevity?
51:05 What kind of approaches have been entered?
01:00:30 AI
01:09:20 Composit end-points
01:13:10 TAME trial stuck because ...
01:19:10 Biomarkers of aging
01:26:50 AI and Biomarkers
01:29:02 The longbio track (be lucky)
01:36:20 Optimism about what?
01:41:00 3 book you have to read
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A pediatric cardiac surgeon turned longevity pioneer, Dr. David Luu shares his journey from humanitarian medical missions to building a global network of physicians focused on prevention. Learn about critical health markers your doctor might be missing, how AI is transforming healthcare, the truth about longevity interventions, and why the future belongs to prevention rather than treatment. Plus, discover the vital link between community, lifestyle, and longevity, and why creating modern "blue zones" might be key to living longer, healthier lives.
🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership
🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: https://peterottsjo.beehiiv.com/
CHAPTERS
00:00 Introduction 02:33 A Family Legacy in Medicine 10:41 From Heart Surgeon to Tech Innovator with JuiSci and Hearty 13:47 Building AI-Powered Medical Platforms 21:33 The Heart Fund: Surgery for Those in Need 35:06 The Role of AI in Healthcare 45:22 Creating Longevity Docs Community 01:07:13 Hidden Cardiovascular Risk Factors 01:10:38 The Lp(a) Test Everyone Should Know About
01:18:50 Why Call it ”Longevity Docs” When We Have No Approved Aging Interventions? 01:28:14 Different Levels of Longevity Interventions 01:38:42 Risk vs. Reward in Preventive Medicine 01:43:30 Building Modern Blue Zones 01:47:11 The Future of Medicine 01:52:07 Connecting with David
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🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership
🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: https://peterottsjo.beehiiv.com/
Meet one of the true legends of the longevity space, James Strole, the visionary founder of RAADfest who embodies relentless optimism and dedication to advancing the frontiers of longevity and human potential. His passion for creating a world where individuals can live longer, healthier lives shines through in every aspect of RAADfest, inspiring countless people to embrace the possibilities of radical life extension.
We will learn about RAADfest and the history of the longevity movement. We will also explore Strole's philosophy of immortality.
- CHAPTERS --
00:00 introduction to James Strole
04:20 RAADfest is the largest longevity event in the world
11:50 personal awakening and the early days of the longevity movement
22:00 longevity as a counter-culture
23:00 death-program vs superlongevity
26:30 1960s spreading the word and rebirthing
31.00 people unlimited and science of superlongevity
33:00 a holistic approach science of mind-set
34:00 alternative medicine not always taken seriously
37:40 the immortality mindset
38:50 aged by culture
44:20 optimism vs pessimism
46:10 optimism about longevity science?
58:50 death-program runs deep
01:03:30 Ray Kurzweil's optimistic prognosis
01:11:00 social consequences of longevity
01:12:30 cryonics is an ambulance to the future
01:15:05 imaginary mortality
01:18:18 immortality via children
01:19:19 is superlongevity egoistic?
01:23:10 handle the loss of near and dear as an immortalist
01:37:50 advice on health and where to be in contact with People Unlimited and James Strole
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🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership
🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: https://peterottsjo.beehiiv.com/
-- IN THIS EPISODE --
Nora Cavani, CEO of Alba Health, shares her journey from struggling with severe eczema and allergies to pioneering breakthrough solutions in children's gut health. After reversing her own chronic conditions through lifestyle changes, she learned how the first years of life critically shape our immune system, metabolism, and lifelong health through the gut microbiome.
As the first company to collaborate with leading microbiome research institutions, Alba Health uses cutting-edge metagenomics technology to analyze children's gut bacteria and provide personalized recommendations. Cavani explains why modern factors like C-sections, antibiotics, and processed foods are leading to a concerning loss of essential gut bacteria in Western children - with many babies now lacking microbes crucial for immune development.
Learn how the gut microbiome affects everything from common childhood ailments to chronic disease risk, why diversity in diet matters, and practical steps parents can take during the critical early window of their child's development. A vital conversation for parents, health optimizers, and anyone interested in preventing chronic disease through early intervention.
-- CHAPTERS --
00:00 Introduction to Nora Cavani
05:08 Microbiome and child health
07:16 Nora’s journey from Italy to Sweden
10:43 Meeting the scientist and microbiologist Willem de Vos
15:20 Laying the groundwork for Alba Health
18:45 Gut microbiome is linked to afflictions in newborns
19:29 The ecosystem of the gut microbiome
21:00 The Ecosystem of the Gut Microbiome
28:33 Gut-brain axis
30:50 C-section and antibiotics
35:10 Alba's testing methodology and insights
41:38 Predicting health through microbiome analysis
45:23 The best time to take the test
54:20 Has Nora managed to get rid of her health issues?
57:19 The role of diet diversity in gut health
01:07:52 What can we still discover about the microbiome?
01:10:05 The role of exercise, sleep and stress in adults
01:12:40 Child health and longevity
01:16:40 Nora’s personal longevity regimen and testing
01:23:36 Oura’s investment i Alba Health
01:28:18 Future of microbiome research
01:32:28 Scientific consensus and controversy
01:43:37 The future for Alba Health
01:45:52 How to get in touch with Nora and Alba
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🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership
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Sergey Jakimov is a founding partner of LongeVC, a VC fund supporting early-stage biotech and longevity-focused founders who are changing the world.
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Niklas Anzinger is the founder of Infinita VC based in the charter city of Prospera in Honduras. He is the co-founder of Vitalia, a longevity focused community. His fund Infinita focuses on a new trend of charter cities and other forms of alternative jurisdictions. He also hosts a podcast about how to accelerate the future by unblocking “stranded technologies”.
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When I first met Emil Kendziorra at the Longevity Biotech Fellowship retreat in Sweden, I found myself captivated by his ability to explain every aspect of cryopreservation for hours. His deep knowledge, combined with his remarkable skill in communicating complex ideas, made me realize this conversation needed to reach a broader audience.
In this comprehensive episode, Emil, CEO of Tomorrow Bio, takes us through the fascinating world of cryopreservation, leaving no stone unturned. We explore:
The science behind cryopreservation and how it differs from simple freezingThe history of cryonics and its evolution into modern cryopreservationStep-by-step details of the preservation processThe logistics of emergency response and stabilizationLong-term storage solutions and safety measuresThe challenges and possibilities of future revivalEthical considerations and philosophical implicationsThe current state of research and future developmentsPractical aspects of signing up and fundingCommon misconceptions and concernsWhether you're curious about cryopreservation as a backup plan for longevity or simply interested in understanding this fascinating field, this episode provides a comprehensive overview of what might be our best bridge to a longer-lived future.
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Todays guest is another California resident, distinguished Professor John Martin Fisher at University of California Riverside. Professor Fischer has as worked on the metaphysics of death and philosophy of religion and led a multi-year, multi-pronged research project on "immortality," funded in 2012 by the John Templeton Foundation.
He is the author of several books including Death, Immortality, and Meaning in Life. (Oxford University Press, 2019). And Near-Death Experiences: Understanding Visions of the Afterlife (co-authored with Benjamin Mitchell-Yellin) (Oxford University Press, 2016)
Learn about:
✅ Near-death experiences
✅ The fear of death
✅ The desirability of immortality
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Longevity superstar Bryan Johnson made waves when he traveled to the Bahamas for a stem cell treatment. But who's behind this cutting-edge therapy? Meet Maria Rankka, co-founder of Cellcolabs, the Swedish startup that's caught the attention of one of the world's biggest longevity influencers.
In this episode of LEVITY, hosts Peter Ottsjö and Patrick Linden dive deep into Cellcolabs' ambitious mission: to revolutionize healthcare by producing cheap and abundant mesenchymal stromal cells (MSCs). Could this be the key to combating inflammation and extending healthspan on a global scale?
Maria Rankka shares the inside story of Cellcolabs' journey, from its inception during the COVID-19 pandemic to its current position at the forefront of regenerative medicine.
Learn about:
✅ The science behind MSCs and why they're creating buzz in longevity circles
✅ Cellcolabs' innovative approach to scaling stem cell production
✅ Maria's personal experience with MSC treatment
✅ The potential of MSCs to transform preventative medicine
✅ Making regenerative treatments accessible to the masses
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This is one of the most amazing new discoveries: We can rejuvenate cells. Next step is to rejuvenate entire organisms, and ultimately human beings including our brains. Yuri Deigin, CEO of YouthBio Therapeutics, is a pioneering drug developer and longevity maximalist currently working on partial reprogramming gene therapies for Alzheimer’s and other diseases.
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There are countless reasons to admire Mark Hamalainen, and one of them is his brutal honesty. While many longevity influencers confidently declare that longevity escape velocity and indefinite lifespans are just around the corner, you won’t get such easy assurances from Mark.
That’s because, and this might seem counterintuitive at first, he’s one of the most deeply committed advocates for solving aging that I’ve encountered. Mark, a former director of science at Synthego and a former researcher at SENS Research Foundation (Aubrey de Grey has called him his protégé), has dedicated over two decades to tackling humanity’s greatest challenge.
You see, Mark's honesty doesn't stem from pessimism, but from a deep commitment to reality-based thinking. His mission isn’t driven by hype but by a relentless pursuit of tangible progress in the fight against aging.
I (Peter) first met Mark at the Longevity Biotech Fellowship (LBF) retreat in Sweden in January 2024, where I had the opportunity to witness his vision and dedication firsthand. It left a lasting impression, not only on me but likely on everyone who attended. Here was someone who wasn’t just dreaming about a future where aging is solved - he was meticulously planning it, working hard to remove the roadblocks that stand in the way.
His work with the LBF, the Longevity Acceleration Roadmap, and his broader efforts in the longevity community are all about taking concrete, actionable steps toward a future where the passing of time is not a death sentence - all the while knowing that this goal is one of the most complex challenges humanity has ever faced.
In this episode, Mark discusses several key strategies that he believes are essential to making real progress. These include advancing bioengineering to gain precise control over biological processes, developing comprehensive data sets to better understand aging at a molecular level, and exploring visionary ideas like the replacement strategy. He also highlights the potential of biostasis and cryopreservation as a last resort, potentially offering a way to preserve life until future technologies can fully reverse aging.
So, while Mark may not offer the easy assurances that some in the longevity space do, he offers something far more valuable: a realistic and deeply informed plan of action, a commitment to truth over convenience, and above all, a profound hope that by facing the realities of aging head-on, we can one day overcome them.
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