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Eugene Oga, a PhD student in Analytical Chemistry at the University of North Dakota, joins David Oliva to discuss his innovative research on silicone sealant degradation using evolved gas analysis and thermal desorption-pyrolysis gas chromatography. With his background in materials chemistry and current focus on analytical techniques, Eugene shares insights into how these advanced methods can characterize material breakdown over time, with significant implications for the construction industry and beyond.Eugene's Background and Research FocusEugene Oga is pursuing his PhD in Analytical Chemistry at the University of North Dakota, following his Bachelor's and Master's degrees from the University of Buea in Cameroon. His academic journey began with a focus on materials chemistry before transitioning to analytical chemistry, recognizing that material properties and performance depend heavily on proper characterization.His current research employs advanced analytical techniques like evolved gas analysis and pyrolysis gas chromatography to understand how materials break down over time and identify the specific fragments produced during degradation. This work aims to provide recommendations to manufacturers about potential improvements to their processes.Understanding Structural Sealant Glazing and Its ImportanceStructural Sealant Glazing (SSG) plays a critical role in modern construction, particularly in buildings that extensively use glass and metal. Eugene explains that sealants are thick liquids used to bind different construction materials together.These sealants serve multiple important functions, including preventing air infiltration, moisture penetration, and enhancing building stability. While studies have estimated how long sealants and buildings should last, they often don't explain the actual breakdown mechanisms. Eugene's research aims to fill this gap by identifying which components are lost over time and how this degradation occurs, ultimately enabling better prediction of failure and development of solutions.Different Failure Modes and Analytical ApproachesEugene identifies several categories of sealant failure that require different analytical approaches:1. Adhesive/cohesive failures: These occur when materials don't properly bind together, often due to surface preparation issues that can be addressed through proper cleaning.2. Chemical degradation: This includes processes like UV exposure, hydrolysis, and oxidation.3. Environmental factors: Temperature fluctuations, moisture, and pollutants can contribute to degradation.4. Physical degradation: Manifesting as cracking, fatigue, and creep.While mechanical analysis can identify physical changes like cracking and strength loss, it doesn't reveal which chemical components are being lost. For all these failure modes, gas chromatography and mass spectrometry prove essential.In all of these different failure modes and causes, gas chromatography and mass spectrometry would be very important to identify the volatile degradation products and the changes that are accompanying the backbone.Innovative Methodological ApproachEugene's research employs a two-step analytical approach that modifies standard GC-MS protocols to accommodate siloxane chemistry:1. Evolved Gas Analysis (EGA-MS): This serves as a rapid screening technique to identify temperature ranges where components evolve.2. Thermal Desorption-Pyrolysis GC-MS: This follows as a verification tool, focusing on the specific temperature zones identified by EGA to perform detailed analysis of components evolving at different temperatures.This sequential approach allows for more targeted analysis and better characterization of degradation products. The method is particularly valuable because it eliminates extensive sample preparation—samples can be analyzed as received, saving significant time and reducing potential preparation errors.
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In this enlightening episode of Concentrating on Chromatography, host David Oliva engages in a comprehensive discussion with Lisa Jones, Director of Higher Education Relations at I.W. Tremont Co. and active NAOSMM volunteer, alongside Jim Averso, Co-President at I.W. Tremont and producer of the LabExact brand of laboratory consumables.
The conversation explores critical aspects of laboratory supply management, including best practices for procurement in academic settings, inventory challenges, and the advantages of American-made products. Lisa shares valuable insights from her 27 years of experience at the University of Alabama, highlighting how institutional policies affect purchasing decisions and the complexities of managing laboratory stockrooms. Jim discusses how I.W. Tremont develops products based on real laboratory workflows and responds to researcher feedback.
Key topics include:
The role of NAOSMM (National Association of Scientific Materials Managers) in connecting laboratory managers with quality suppliers
Challenges of cylinder-based nitrogen supply versus on-demand nitrogen generation
The importance of vendor selection criteria including quality certification, inventory availability, and customization capabilities
How academic procurement processes vary between institutions and departments
The value of American manufacturing and family-owned businesses in the scientific supply chain
Whether you're managing university laboratory resources, working in a research facility, or supplying the scientific community, this episode offers practical perspectives on streamlining your supply chain while maintaining research quality and addressing the unique challenges of laboratory operations.
#LabSupplies #AcademicResearch #LabManagement #NAOSMM #ScientificProcurement #ChemistryLab #LabExact
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In this episode of Concentrating on Chromatography, host David Oliva interviews Jim Averso, Co-President of I.W. Tremont and manufacturer of the LabExact brand, celebrating their 45th year in business. Jim shares expert insights on the critical role of filtration in chromatography sample preparation.Discover:- Why proper filtration is essential for protecting your expensive HPLC columns- How to select the right membrane type (Nylon, PTFE, PVDF, or PES) based on your sample- Common mistakes researchers make with syringe filters and how to avoid them- The innovative TruPor membrane technology that increases loading capacity while improving flow rates- Tips for preventing membrane intrusion and back pressure issues- The new HandyPrep device that simplifies pre-filtration steps- Advanced techniques like filter stacking for improved sample preparationWhether you're working with HPLC, UHPLC, GC, or other chromatography methods, this conversation provides valuable insights to optimize your workflow and improve analytical results.Jim also discusses the Laboratory Products Association's student engagement committee, which is building bridges between academia and commercial science careers.#Chromatography #LabTechniques #SamplePreparation #HPLC #Filtration #LabExact #ScienceEducation
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Join us on the Concentrating on Chromatography podcast as David Oliva interviews Katelynn Perrault Uptmor, PhD about her recent article, "Detangling the Complex Web of GC x GC Method Development to Support New Users." In this insightful conversation, Katelynn explains the basics of comprehensive two-dimensional gas chromatography (GC x GC), its advantages over traditional one-dimensional GC, and shares practical tips for overcoming common challenges faced by new users.Discover how GC x GC vastly increases separation capacity by combining two columns with different stationary phases, allowing for more efficient analysis of complex samples. Katelynn discusses the key steps in method development, including establishing a good one-dimensional separation, using chromatogram modelers to predict peak behavior, and fine-tuning modulator parameters for optimal peak shape and resolution.Learn about choosing the right column combinations for your specific application, understanding the importance of orthogonality between columns, and leveraging resources like literature and expert advice to optimize your setup. Explore real-world applications of GC x GC in fields like forensics, food analysis, environmental science, and petroleum analysis, where this technique is revolutionizing routine analysis.Whether you're a seasoned chromatographer or just starting out, this interview offers valuable insights into the power and accessibility of GC x GC. Katelynn also shares her recent recognition as an Emerging Leader in chromatography and highlights the exciting work of her undergraduate research group. Katelynn is currently Assistant Professor of Chemistry at William and Mary.
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Dive into the world of cutting-edge catalysis research with Dr. Roberto Silva Villatoro in this captivating episode of Concentrating on Chromatography. Hosted by David Oliva, General Manager of Organomation, this interview explores how high-resolution mass spectrometry (HRMS) is revolutionizing our understanding of palladium-catalyzed reactions.Key highlights:- Discover how HRMS detects elusive organometallic intermediates- Learn about overcoming air-sensitivity challenges in sample preparation- Explore the implications of off-cycle species in catalytic processes- Gain insights into the future of C-X and C-C bond-forming reactionsWhether you're a chemistry enthusiast, a seasoned researcher, or an industry professional, this interview offers valuable insights into the intricate world of catalytic mechanisms. Join us as we uncover the potential for cleaner, more efficient chemical processes and the power of interdisciplinary collaboration in advancing scientific discovery.Don't forget to like, subscribe, and hit the notification bell to stay updated on the latest in chromatography, mass spectrometry, and sample preparation!#Catalysis #MassSpectrometry #ChemistryResearch #Chromatography #ScientificDiscovery
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Join us for an insightful interview with Dr. Isaiah Speight, Assistant Professor at William and Mary, as he discusses his groundbreaking work in sustainable chemistry and innovative chromatography techniques. In this engaging conversation, Prof. Speight shares:- His research focus on sustainable chemistry from synthesis, financial, and educational perspectives- The importance of NOBCChE (National Organization for the Professional Advancement of Black Chemists and Chemical Engineers)- How HPLC and flash chromatography enable synthetic chemistry- The advantages of automated flash chromatography systems- Method development processes for new compounds and reactions- Exciting ongoing projects, including 3D-printed mechanochemical reaction vessels and mercury-centered metal-organic frameworksDiscover how Prof. Speight's lab is pushing the boundaries of sustainable chemistry while training the next generation of undergraduate researchers. This interview offers valuable insights for chemists, students, and anyone interested in the future of sustainable scientific practices.#SustainableChemistry #Chromatography #STEM #NOBCChE #ResearchInnovation
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Dive into the world of environmental toxicology with Andrea Andress Huacachino, a PhD student at the University of Pennsylvania. In this fascinating interview, Andrea discusses her groundbreaking research on PFAS (per- and polyfluoroalkyl substances) and their impact on androgen regulation. Learn about:- The novel finding of PFOA's effect on pre-receptor androgen regulation- Innovative use of radio chromatography in hormone analysis- Challenges in developing HPLC methods for androgen separation- The broader implications of androgen dysregulation on human healthDiscover how environmental pollutants affect hormones in all humans and why this research matters for everyone. Perfect for science enthusiasts, students, and anyone interested in the intersection of chemistry and human health.#EnvironmentalToxicology #PFAS #Androgens #ChemistryResearch #ScienceInterview
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Dr. Caitlin Cain discusses her groundbreaking research on potato taste defect (PTD) in coffee using comprehensive two-dimensional gas chromatography (GC×GC). Learn how this advanced technique revealed 359 class-distinguishing analytes related to PTD, providing unprecedented insights into this complex flavor issue.Key points covered:- Advantages of GC×GC over traditional one-dimensional GC for complex samples- Optimization of headspace solid-phase microextraction for coffee volatile analysis- Surprising findings from the comprehensive volatile profile of PTD-affected coffee- Implications for coffee farmers and the industry in combating PTDDiscover how this research is advancing our understanding of coffee chemistry and potentially improving coffee quality worldwide.#CoffeeScience #Chromatography #AnalyticalChemistry #FoodChemistry
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Dive into the cutting-edge world of natural product discovery with Jess Deng, a fourth-year PhD candidate at Queen's University. In this engaging interview, Jess discusses her groundbreaking research using ambient ionization mass spectrometry to streamline the discovery of novel fungal metabolites.Key highlights:- Learn about the liquid microjunction surface sampling probe (LMJ SSP) and its advantages- Discover how Jess is tackling the time and resource challenges in natural product research- Explore the effects of light conditions and environmental factors on fungal metabolism- Hear about Jess's exciting work at the Smithsonian Museum of ConservationFrom rapid screening techniques to machine learning algorithms, Jess shares insights that could reshape the future of pharmaceutical research and biofuel production. Don't miss this fascinating look into the intersection of mass spectrometry, fungal biology, and drug discovery!#MassSpectrometry #NaturalProductDiscovery #FungalMetabolites #PhDResearch #ASMS2024
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In this insightful interview, Medicinal Chemist Schyler Odum discusses his work in antibiotic drug discovery and the critical role of Ultra-High Performance Liquid Chromatography (UPLC) in his research. Schyler, a fifth-year graduate student at UTHSC, shares his expertise on:The importance of antibiotic drug discovery in academic institutionsHow UPLC differs from HPLC and its benefits in chemical analysisChallenges in sample preparation and potential improvementsThe complexities of synthesizing large molecular weight antibioticsThe need for increased support and funding in antibiotic researchSchyler also highlights the Gordon Research Conferences as a platform for presenting antibiotic drug discovery work. This video offers valuable insights for chemistry students, researchers, and anyone interested in the future of antibiotic development.#AntibioticResearch #MedicinalChemistry #UPLC #DrugDiscovery #GraduateResearch
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Dive into the world of sample preparation with industry expert Wade Hasenour as he shares invaluable insights on rotary evaporation, centrifugal evaporation, and freeze drying. Learn about the latest advancements, challenges, and future trends in sample prep techniques for chromatography. Discover how to choose the right method for your needs, optimize your workflow, and leverage automation for better results. Whether you're a seasoned chromatographer or just starting out, this video offers essential knowledge to enhance your sample preparation skills and achieve more reliable outcomes in your research.#Chromatography #SamplePreparation #LabTechniques #ScientificResearch #massspectrometry
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Dive into the cutting-edge world of pharmaceutical analysis with Mark Dennis Retrato, a PhD candidate at Uppsala University. In this exclusive interview, Mark shares his groundbreaking research on developing a novel UPLC-MS method for analyzing phospholipids in total parenteral nutrition (TPN) products.Key highlights:• Innovative UPLC-MS method for phospholipid quantification• Importance of nitrogen evaporation in sample preparation• Unexpected findings in phosphatidylcholine species• Implications for quality control in pharmaceutical manufacturing• Potential impact on patient care and TPN product stabilityLearn how this research is pushing the boundaries of analytical chemistry and contributing to improved healthcare outcomes. Whether you're a scientist, healthcare professional, or simply curious about advancements in medical technology, this interview offers valuable insights into the future of parenteral nutrition analysis.Don't forget to like, subscribe, and hit the notification bell to stay updated on the latest developments in chromatography and mass spectrometry!#UPLCMS #ParenteralNutrition #PharmaceuticalAnalysis #Chromatography #MassSpectrometry #PhDResearch
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Join Organomation's General Manager David Oliva as he interviews Bianca Costa, a PhD researcher from the University of Southern California, about her groundbreaking work on PFAS (per- and polyfluoroalkyl substances). In this in-depth discussion, Bianca shares her experiences and insights on:• The complexities of PFAS sampling and analysis in various environmental matrices• Challenges in method development for PFAS extraction and detection• The use of advanced analytical techniques like LC-MS for PFAS research• Emerging biotechnologies for PFAS remediation and the potential for microbial transformation• Community engagement efforts to assess PFAS exposure in Southern CaliforniaDiscover the latest advancements in PFAS research and the interdisciplinary approach needed to tackle this widespread environmental challenge. Whether you're a researcher, environmental professional, or simply interested in cutting-edge science, this interview offers valuable insights into the world of PFAS and environmental chemistry.#PFAS #EnvironmentalChemistry #WaterQuality #AnalyticalChemistry #Chromatography #Biotechnology #USC
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Join us for an interesting interview with Taylor Bias, a leading researcher in the field of mitochondrial proteins, as she discusses her groundbreaking work on mitoNEET and its implications for diseases like Type 2 Diabetes, Parkinson's Disease, and Cancer. In this engaging conversation with Organomation General Manager David Oliva, Taylor shares the challenges she faced in developing analytical methods to study mitoNEET's enzymatic activities and the pivotal role of chromatography techniques like GC-MS and HPLC in her research.Discover how chromatography is evolving in the study of complex proteins and hear about some unexpected findings that have emerged from Taylor's research. For young researchers eager to dive into interdisciplinary studies, Taylor offers valuable advice on navigating this exciting field. Additionally, she addresses common misconceptions about mitoNEET and clarifies its significant role in disease mechanisms.Don't miss this opportunity to learn from an expert about the fascinating intersection of biochemistry, disease research, and advanced analytical techniques!
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In this episode of "Concentrating on Chromatography," host David Oliva explores diverse applications of chromatography and mass spectrometry with researchers from the University of Nevada, Reno. The discussion covers a range of topics, including:
PFAS research and thermal destruction processes Short-chain fatty acid production in gut microbiomes using GC-MS Cortisol analysis in sheep wool for welfare studies using ELISA The versatility of university core laboratories in supporting various research projectsListeners will gain insights into cutting-edge research methodologies, sample preparation techniques, and the critical role of chromatography in environmental science, microbiology, animal welfare, and beyond. This episode highlights the interdisciplinary nature of analytical chemistry and its impact on addressing real-world challenges.
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In this insightful interview, David Oliva, General Manager of Organomation, sits down with Jonathan Navarro Ramos, a PhD student at the University at Buffalo, to discuss his cutting-edge research on environmental pollutants. Jonathan shares his journey in developing methods to detect tire-derived chemicals like 6PPD and 6PPD-quinone in stormwater runoff and highlights the importance of non-target analysis using high-resolution mass spectrometry (HRMS).Key Topics Covered:Research on 6PPD and its transformation into 6PPD-quinoneEnvironmental and public health concerns surrounding tire-derived chemicalsThe use of LC-MS/MS in detecting pollutants in challenging matricesSample preparation techniques, including solid-phase extraction and nitrogen blowdown with the Organomation N-EVAPFuture research directions involving the chlorination of pollutants in wastewater treatmentLearn More: Jonathan also shares surprising findings from his study and emphasizes the global ubiquity of tire-derived pollutants. Don't miss this engaging discussion!👉 Follow us for more updates on environmental research, chromatography techniques, and advanced laboratory equipment.#EnvironmentalResearch #TireChemicals #LCMS #MassSpectrometry #SamplePreparation #Organomation #PollutantDetection #PhDResearch
