Avsnitt
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For the third time, Joe and Rolf talk to Dr. Balazs Szigeti about psychedelics for the treatment of depression. This time, Balazs discusses his recent paper that shows an equivalence between psychedelics and traditional medications in effectiveness for treating depression. This is surprising, given the size of effects that have been demonstrated in some early psychedelic trials, and can be accounted for, in part, by patient expectations.
Williams ZJ, Barnett H, Szigeti B. Psychedelic Therapy vs Antidepressants for the Treatment of Depression Under Equal Unblinding Conditions: A Systematic Review and Meta-Analysis. JAMA Psychiatry. Published online March 18, 2026. doi:10.1001/jamapsychiatry.2025.4809
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On this episode, Rolf and Joe talk to Dr. Valerie Bonnelle, a cognitive neuroscientist interested in the relation of processes in the body to peak experiences. We discuss her paper showing how heart rate variability and the interplay between the sympathetic and parasympathetic nervous systems closely tracks phenomenological experience during the use of the psychedelic DMT.
Bonnelle, V., Feilding, A., Rosas, F. E., Nutt, D. J., Carhart-Harris, R. L., & Timmermann, C. (2024). Autonomic nervous system activity correlates with peak experiences induced by DMT and predicts increases in well-being. Journal of Psychopharmacology, 38(10), 887-896.
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Saknas det avsnitt?
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What do the National Institutes of Health (NIH) do, and who works there? Rolf and Joe talk to Dr. Bradley Cooke, who works at the NIH as a Program Director in the Division of Diabetes, Endocrinology, and Metabolic Diseases (located within the National Institute of Diabetes and Digestive and Kidney Diseases). Dr. Cooke talks about the research he conducted when he was in the academic world, including work on the biology of attraction and sex differences in the brain, and then discusses how the NIH monitors and guides the national research agenda, some of the essential and groundbreaking research the NIH has funded, as well as exciting research trends coming our way.
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Fresh from Psychedelic Science 2025, Dr. Steve Levine, the chief patient officer at Compass Pathways, talks to us about new Phase 3 results for psilocybin in treating depression.
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Joe reports back from the Psychedelic Science conference held recently again in Denver, Colorado. After some discussion about the conference, Joe speaks with Balasz Szigeti (who was on the podcast in 2023) about his recent work on the "Placebo Suppression Effect" in psychedelic research.
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Joe and Rolf talk to blind activist and friend of the show Josh Miele. Josh, a MacArthur Genuis Award winner and prodigious sushi eater, has just come out with a new autobiographical book called "Connecting Dots: A Blind Life". We talk about his life growing up in Park Slope, his freewheeling youth, the dog vs. cane debate, and his career as a blind accessibility scientist and inventor.
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Rolf and Joe talk to NYU philosopher Jeff Sebo about his new book "The Moral Circle", which makes the case for expanding our circle of who is deserving of ethical consideration to nonhuman animals, insects, plants, and AI systems.
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Rolf and Joe wrap up their 3-part series on dreaming with Finnish neuroscientist and philosopher Antti Revonsuo. Dr. Revonsuo is the originator of the Threat Simulation theory of dreams, which suggests that dreams are simulated worlds in which we may practice threatening situations. Topics include the history and methodology in dream research, how our brains create simulated worlds, the particular nature of the simulated dream world, and how this applies to waking consciousness. We base our discussion on three forthcoming papers:
Revonsuo, A. (in press) Toward a Metaphysics of Consciousness: Science and the Fundamental Nature of Subjective Experience. To appear in The Scientific Study of Consciousness: Experimental and Theoretical Approaches. (Springer Nature).
Revonsuo, A. & Tuominen, J. (in press) The Concept of Dreaming as a World. To appear in Threshold Worlds (Oxford University Press).
Revonsuo, A., Valli, K., & Tuominen, J. (in preparation) Evolutionary Simulation Theories of Dreaming.
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In their second episode in a series on dreaming, Joe and Rolf are joined by Dr. Pilleriin Sikka, a Stanford neuroscientist who is currently studying the therapeutic value of dreams under anesthesia.
Hack, L. M., Sikka, P., Zhou, K., Kawai, M., Chow, H. S., & Heifets, B. (2024). Reduction in Trauma-Related Symptoms After Anesthetic-Induced Intra-Operative Dreaming. American Journal of Psychiatry, 181(6), 563-564.
https://psychiatryonline.org/doi/full/10.1176/appi.ajp.20230698
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Why do we dream, and what is the meaning of our dreams? Rolf and Joe talk about several ideas about dreaming, including a new theory by David Eagleman called the "defensive activation theory", which proposes that dreams are like a screen saver to keep the visual parts of the brain from being overtaken by other senses.
Eagleman, D. M., & Vaughn, D. A. (2020). The Defensive Activation theory: dreaming as a mechanism to prevent takeover of the visual cortex. bioRxiv, 2020-07.
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Daniel Dennett, who passed away on April 19th at the age of 82, was one of the great philosophers of our time. Rolf and Joe discuss his ideas and his influence on the field of philosophy, including (especially) bringing consciousness back as a topic of serious study with his book "Consciousness Explained", as well as his work on free will, evolution, religion, and constructing a convincing argument.
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What can neuroscience teach us about AI, and vice versa, what can AI teach us about our own intelligence?
Joe and Rolf talk to returning guest Daniel Sternberg about advances in AI over the past year. Topics include using the methods of cognitive psychology to understand AI; representation in artificial intelligence; what current large language models (LLMs) are good at and not good at; sentience in AI; the future of humanity; and other important stuff.
Natural and Artificial Intelligence: A brief introduction to the interplay between AI and neuroscience research (Macpherson, et al., 2021)
Can AI language models replace human participants? (Dillion, et al., 2023)
Language models show human-like content effects on reasoning (Dasgupta et al., 2022)
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This episode is dedicated to the memory of colleague and friend Grace Baron.
Joe and Rolf talk to Dr. Matthew Goodwin, a professor at Northeastern University whose research focus is on autism. His most recent paper used biosensing (heart rate, skin conductance, etc.) to predict aggressive behavior in profound autistic individuals up to three minutes before the event.
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Joe and Rolf discuss the ideas of perceptual psychologist Donald Hoffman, who has argued that our perceptual systems have no access to reality, since evolution is driven by fitness functions, not objective truth. He has also argued that our perception is a user interface (like a desktop on a computer, or a VR headset), and that objects such as the moon don't exist when we are not apprehending them.
Hoffman, Donald. The case against reality: Why evolution hid the truth from our eyes. WW Norton & Company, 2019.
Bagwell, J. N. (2023). Debunking interface theory: why Hoffman’s skepticism (really) is self-defeating. Synthese, 201(1), 25.
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Neil Markey, a veteran of Iraq and Afghanistan, used meditation for years to deal with depression and PTSD. He is currently CEO of Beckley Retreats, a group that runs retreats to Jamaica and the Netherlands for guided psychedelic experiences. He talks about his path from the military to consulting to his work with Beckley, how guided psychedelic retreats are run (including work to prepare in advance, as well as to integrate after), and how he envisions the future of psychedelics for both treatment of disorders and for enhancing quality of life for those without disorders.
Special Guest: Neil Markey.
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We discuss the recent controversy about Integrated Information Theory (IIT), a theory about the neural correlates of consciousness, with Felipe De Brigard, a philosophy and psychology professor at Duke University who signed a letter describing the theory as pseudoscience.
The letter: https://osf.io/preprints/psyarxiv/zsr78/
The adversarial collaboration: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0268577
Description of IIT: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011465 -
Joe and Rolf talk to psychedelic researcher Robin Carhart-Harris. Robin is at the cutting edge of research on the therapeutic benefits of psychedelics such as psilocybin (magic mushrooms), LSD, and DMT. He discusses psychotherapy and the unconscious mind, models of what psychedelics are doing in the brain, and many other topics. A really fascinating and in-depth conversation.
You can find links to his published research as well as a series of videos on harm reduction at the following link:
https://www.carhartharrislab.com/
Special Guest: Robin Carhart-Harris.
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Joe and Rolf discuss new work in neural interfaces that is helping paralyzed individuals communicate.
Based on the recent Nature article:
Metzger, S. L., Littlejohn, K. T., Silva, A. B., Moses, D. A., Seaton, M. P., Wang, R., ... & Chang, E. F. (2023). A high-performance neuroprosthesis for speech decoding and avatar control. Nature, 1-10.
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Rolf and Joe discuss two philosophical theories of the self, Bundle Theory and Ego Theory, based on a paper by Derek Parfit. They return to the topic of the teletransporter, and although Joe is happy to go through the teletransporter, Rolf is convinced it means certain death.
Parfit, D. (2016). Divided minds and the nature of persons. Science Fiction and Philosophy: From Time Travel to Superintelligence, 91-98.
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In this episode, CogNation goes to the Psychedelic Science conference in Denver to get in on all the excitement. We present four interviews from the conference that represent a range of ideas about the resurgent interest in psychedelics as therapeutics.
Bekely Waves
The East Institute
Balasz Szigeti
Manoj Doss - Visa fler
