Avsnitt
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Neurologist Dr. David Perlmutter Explains Brain Inflammation and Alzheimer's Risk
Your brain has its own immune system, and when it turns against you, it becomes the hidden driver behind Alzheimer's, Parkinson's, depression, and even long COVID. This episode hands you the science to recognize it early and reverse it.
Get Dr. Perlmutter’s new book Brain Defenders: https://drperlmutter.com/books/brain-defenders/
Host Dave Asprey sits down with Dr. David Perlmutter, a board-certified neurologist and six-time New York Times bestselling author whose work sits at the intersection of neurology, nutrition, and brain health. He is a Fellow of the American College of Nutrition, serves on its Board of Directors, and sits on the Editorial Board of the Journal of Alzheimer's Disease. His books, including the number one bestseller Grain Brain, span 32 languages and have sold over a million copies, and his upcoming release, Brain Defenders, explores the pivotal role of microglia, the brain's immune cells, in protecting, repairing, and reprogramming the brain for lifelong resilience.
Dave and Dr. Perlmutter break down how microglia, the brain's resident immune cells, shift from a supportive state into a destructive one called M1, and why this shift, not amyloid plaque, may be the real driver of Alzheimer's, Parkinson's, and other neurodegenerative conditions. They dig into why the leading amyloid-clearing drugs fail to improve cognition, what a landmark JAMA study revealed about reversing cognitive decline through lifestyle intervention alone, and why a single daily serving of ultra-processed food raised Alzheimer's risk by 13 percent in a 12.7 year study. They also cover new research on GLP-1 drugs and brain inflammation, the surprising role of gum disease and oral bacteria in dementia risk, and why 40 hertz light therapy is emerging as a low-cost tool for clearing brain plaque and calming neuroinflammation.
You'll Learn:
Why the shift from supportive to destructive brain immune cells may be the true root cause of Alzheimer's and Parkinson's Why leading Alzheimer's drugs fail to improve cognition, and what the original research behind the amyloid hypothesis actually showed How one daily serving of ultra-processed food raises Alzheimer's risk, and what a landmark lifestyle intervention study found instead Whether GLP-1 drugs help or harm brain inflammation, based on new Parkinson's and Alzheimer's trial data How gum disease and oral bacteria are linked to dementia, and simple daily habits that reduce that risk Why 40 hertz light therapy is emerging as a tool to clear brain plaque and calm neuroinflammation How ketones, DHA, and metabolic health protect the brain after head injuryThank you to our sponsors!
- Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com.
- ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.
- Pique | Head over to Piquelife.com/Dave to get 20% off your order. That's P-I-Q-U-E life dot com slash DAVE
- PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off.
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.
New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.
Keywords: microglia, brain inflammation, Alzheimer's prevention, Parkinson's disease, amyloid hypothesis, neurodegeneration, GLP-1 drugs, semaglutide, ultra-processed food, gum disease and dementia, oral microbiome, 40 hertz light therapy, ketones, DHA, mitochondria, brain fog, long COVID, David Perlmutter, Brain Defenders, Grain Brain, functional medicine, biohacking, longevity, neuroplasticity
Resources:
• Get Dr. Perlmutter’s New Book Brain Defenders: https://drperlmutter.com/books/brain-defenders/
• Learn More About Dr. Perlmutter’s Work At: https://drperlmutter.com/
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15?
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com
Timestamps:
00:00 – Trailer
00:40 – Intro
02:38 – Ultra-Processed Foods
06:34 – Are Carbs Bad?
08:48 – Alcohol & Brain Health
12:28 – Microglia & Inflammation
24:37 – Head Injury & Recovery
29:27 – Oral Bacteria & Dementia
34:08 – GLP-1s & Brain Inflammation
40:20 – 40 Hertz Light Therapy
48:35 – Air Pollution vs. Lead
50:27 – David's Closing Truth
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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Near-Infrared Light Therapy & EMF Shielding with SaunaSpace Founder Brian Richards
Your mitochondria are starving for a nutrient you've probably never tracked, and it's not a vitamin or a macro. This episode reveals how a forgotten 1910 therapy uses light to physically restructure water inside your cells, unlocking a mechanism for healing, detox, and mitochondria repair that most of biohacking has completely overlooked.
Go to https://sauna.space/ and use code ‘Dave’ for a 15% discount!
Host Dave Asprey sits down with Brian Richards, founder of SaunaSpace and a leading voice in incandescent light therapy and infrared sauna engineering. With a background in chemistry and organic synthesis, Brian spent over a decade building a science-backed alternative to LED-based light therapy rooted in full-spectrum incandescent light and deep radiant heat. After healing his own insomnia, adrenal fatigue, and brain fog through light and heat exposure, he developed the FireLight Spectrum, a technology engineered to restore what modern lighting strips away.
Dave and Brian trace incandescent light therapy back to Dr. John Harvey Kellogg's 1910 book on light therapeutics, and explain why the same institutional forces that suppressed chiropractic care and natural medicine buried this practice for over a century. They break down how near-infrared light penetrates the body to charge water into a more bioavailable state, boost glutathione and melatonin production, and repolarize cellular voltage for better metabolism and longevity. The conversation also covers why blue light from LEDs devastates hormones, testosterone, and fertility, how EMF exposure silently drains human performance, and why grounding and Faraday shielding matter more than most supplements on the market.
You'll Learn:
Why near-infrared light functions as an essential nutrient your body cannot make without it How light physically restructures water to improve mitochondria function and cellular energy The suppressed history of Dr. Kellogg's incandescent light therapy and why it disappeared How blue light exposure crashes testosterone and disrupts fertility and hormone regulation Why EMF shielding and grounding are critical, overlooked tools for longevity and recovery How to use infrared light like a daily supplement instead of an occasional treatment Why carnivore-adjacent, nutrient-dense eating pairs naturally with light and heat therapyThank you to our sponsors!
- ELITE Performance Coaching | If you’d like to discover where you may be addicted to struggle, allergic to success, and what may be standing between you and your next breakthrough, visit FastestChange.com
- Longevity Farms | Go to getlongevityfarms.shop. Use code DAVE for 20% off your next order.
- Calroy | Go to calroy.com/dave for the clinical research, your discount, and a 45-day money-back guarantee.
- PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off.
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.
New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.
Keywords: Brian Richards, SaunaSpace, incandescent light therapy, near-infrared light, FireLight Spectrum, Dr. John Harvey Kellogg, Light Therapeutics, exclusion zone water, Gerald Pollack, EMF shielding, Faraday cage, grounding mat, earthing, redox potential, mitochondrial energy, glutathione, melatonin, blue light toxicity, circadian biology, red light therapy, heat shock proteins, vitamin D, sun callus, Danger Coffee, Flexner Report, testosterone, biophotons
Resources:
• Go to https://sauna.space/ and use code ‘Dave’ for a 15% discount!
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15?
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com
Timestamps:
00:00 – Trailer
00:46 – Meet Brian Richards
03:17 – Kellogg's Light Bath History
09:04 – Persecuted Light Pioneers
12:47 – Near-Infrared Science
16:07 – Blue Light Damage
19:26 – Sunscreen Myths
23:52 – Antidote & Melatonin
33:24 – Exclusion Zone Water
37:52 – Heart as a Vortex
41:47 – Fireplace & Infrared Deficiency
46:15 – FireLight Bulb Design
51:52 – EMF Shielding
55:16 – Faraday Cage & Grounding
1:05:51 – Sauna.Space Discount
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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Saknas det avsnitt?
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Try Danger Creatine: https://dangercoffee.com/products/danger-creatine
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Try Danger Coffee: https://dangercoffee.com/
Try Suppgrade Labs: https://shopsuppgradelabs.com/
I have spent twenty years and millions of dollars testing every legal focus drug I could get my hands on. In this video, I break down which compounds actually work, which ones are a waste of money, and the exact stack that delivers hours of clean focus without the afternoon crash.
The shift is simple: focus isn't a willpower problem. It's an energy production problem inside your brain. Once you fuel it at the cellular level, deep focus stops being a struggle and becomes the default state.
Thank you to our sponsors!
ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off.iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:
0:00 – The Longevity Switch
0:47 – Why Mitochondria Matter
2:28 – What Mitophagy Is
2:46 – How Mitophagy Works
4:18 – What Shuts It Off
8:54 – The Damage Compounds
9:22 – How to Turn It Back On
10:31 – Signal 1: Fasting
11:48 – Signal 2: Exercise (REHIT)
12:30 – Signal 3: Cold Exposure
13:22 – Signal 4: NAD+
14:29 – Signal 5: Urolithin A and Spermidine
Connect with Dave Asprey!
Website: https://daveasprey.com
TikTok: https://www.tiktok.com/@daveaspreyofficial
Instagram: https://www.instagram.com/dave.asprey/
Facebook: https://www.facebook.com/Daveaspreyofficial/
X: https://x.com/daveasprey
YouTube: https://www.youtube.com/c/daveaspreybpr
The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/
Danger Coffee: https://dangercoffee.com/DAVE15
Dave Asprey’s BEYOND Conference: https://beyondconference.com/
Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15
Upgrade Labs: https://upgradelabs.com
40 Years of Zen: https://40yearsofzen.com
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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GLP-1 Side Effects, Gut Microbiome & Brain Health, Toxoplasmosis Risks, and the Dirty Dozen Explained
Plasma Acetate Emerges As Key Gut-Brain Messenger In Older Adults
A study published in Nature Communications examined how gut bacteria relate to plasma acetic acid, a short-chain fatty acid produced when gut microbes ferment fiber, and found that higher acetate levels tracked with lower triglycerides, higher HDL cholesterol, lower body fat, larger thalamic brain volume, and stronger performance on judgment-related cognitive tasks. Mediation analysis showed acetate acts as a direct link between specific gut bacteria, including Oscillibacter and Coprococcus, and these health outcomes. Host Dave Asprey breaks down why this elevates fiber fermentation, not fermented beverages, as the real lever for gut-brain health, and separates the evidence-backed mechanism from the kombucha-as-shortcut assumption.
Source:
https://www.nature.com/articles/s43856-026-01566-x
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GLP-1 Drugs Linked To Sharp Rise In Smell And Taste Disturbances
A JAMA Otolaryngology cohort study tracking over 438,000 GLP-1 users against matched controls found a 48% higher risk of new smell or taste disturbances over two years, with smell disturbances up 81% and taste disturbances up 52%. Diagnoses included anosmia, parosmia, and parageusia, with researchers pointing to GLP-1 receptor activity in the olfactory bulb and other chemosensory pathways as a possible mechanism. Host Dave Asprey unpacks why this signal got buried under muscle loss and gut motility headlines, and what it means for anyone currently on or considering GLP-1 therapy.
Sources:
https://jamanetwork.com/journals/jamaotolaryngology/article-abstract/2850571
https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/10.1001/jamaoto.2026.1498
https://trial.medpath.com/news/glp-1-receptor-agonists-linked-to-increased-risk-of-smell-and-taste-disturbances-study-finds
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Scientists Push For Toxoplasmosis To Be Recognized As A Neglected Tropical Disease
A viewpoint paper in PLOS Neglected Tropical Diseases argues that toxoplasmosis, a parasitic infection carried by roughly one in three people globally, deserves WHO neglected tropical disease status given its outsized impact on vision and maternal-child health. Ocular toxoplasmosis is the most common intra-ocular infection worldwide, and an estimated 190,000 babies are born with congenital toxoplasmosis each year, concentrated in low-resource regions. Despite the scale, there is still no vaccine and no standard global treatment protocol. Host Dave Asprey explains why common, quiet health threats get chronically underfunded compared to dramatic outbreaks, and what pregnant listeners specifically should know about exposure risk.
Source:
https://www.sciencealert.com/parasite-affecting-1-in-3-people-is-a-serious-risk-to-human-health-scientists-warn
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Yale-Oxford Data Shows Exercise May Boost Mental Health More Than A Raise
An analysis of CDC survey data from over 1.2 million U.S. adults found that people who exercise regularly report 1.5 to 2 fewer poor mental health days per month than non-exercisers, a benefit comparable to earning about $25,000 more per year. The data also revealed an inverted-U relationship, with optimal benefits at three to five sessions a week and diminishing or reversed returns at extreme volumes. Host Dave Asprey breaks down why moderate, consistent movement outperforms income as a mental health lever, and why overtraining carries its own psychological cost.
Sources:
https://www.weforum.org/stories/2019/04/exercise-officially-makes-you-happier-than-money-according-to-yale-and-oxford-research/
https://medicine.yale.edu/news-article/exercise-linked-to-improved-mental-health-but-more-may-not-always-be-better/
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Unilever Reportedly Exploring $4 Billion Bid For Supplement Brand Thorne
Unilever is said to be evaluating a bid for Thorne, the clinical-grade supplement brand currently owned by private equity firm L Catterton, in a deal that could value the company at up to $4 billion, with Haleon also reportedly circling. The move reflects a broader trend of major consumer-health conglomerates acquiring practitioner-trusted, lab-forward wellness brands. Host Dave Asprey weighs in on what happens to product quality and innovation when founder-led, science-first supplement companies get absorbed into shareholder-first parent corporations.
Source:
https://www.reuters.com/business/unilever-explores-bid-supplements-maker-thorne-ft-reports-2026-06-26/
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New Research Maps How Your Microbiome Processes Plant Compounds, And What It Means For Your Produce Aisle Choices
Researchers mapped 775 phytonutrients from over 1,100 edible plants against nearly 2,000 gut bacterial enzymes across thousands of human microbiomes, linking that enzyme activity to outcomes in IBD, colorectal cancer, and fatty liver disease. Individuals varied widely in how many of these compounds their gut could actually process, and in mouse studies, strawberries reduced colitis activity only in mice with an intact microbiome. Host Dave Asprey explains why the plant itself isn't the active ingredient, your bacteria are, and connects the findings to this year's Environmental Working Group Dirty Dozen and Clean Fifteen lists to help listeners decide where organic actually matters.
Sources:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12768975/
https://www.eurekalert.org/news-releases/1108351
https://www.nature.com/articles/s41564-025-02197-z
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This episode is designed for biohackers, longevity enthusiasts, and high-performance listeners who want mechanism-level insights into the gut-brain axis, an underreported GLP-1 side effect, a global parasite hiding in plain sight, the real ROI of exercise on mental health, consolidation in the supplement industry, and how your microbiome determines what your produce actually does for you. Host Dave Asprey connects clinical research, large cohort studies, mechanistic biology, and industry news into practical frameworks for improving gut health, brain performance, and long-term resilience.
New episodes every Tuesday, Thursday, Friday, and Sunday.
Keywords: plasma acetate gut brain axis, short chain fatty acids, gut microbiome cognition, GLP-1 smell taste disturbances, anosmia parosmia GLP-1, semaglutide side effects, toxoplasmosis neglected tropical disease, Toxoplasma gondii health risks, congenital toxoplasmosis, exercise mental health study, exercise versus income happiness, overtraining mental health, Unilever Thorne acquisition, supplement industry consolidation, phytonutrient gut bacteria enzymes, polyphenol metabolism microbiome, Dirty Dozen Clean Fifteen 2026, pesticide residue produce, biohacking news 2026, Dave Asprey, The Human Upgrade
Thank you to our sponsors!
- PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off.
- Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.
- iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE
Resources:
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com
Timestamps:
00:00 – Story #1: Acetate & Gut-Brain Health
01:57 – Story #2: GLP-1s & Smell/Taste Loss
03:22 – Story #3: Toxoplasmosis Risks
04:33 – Story #4: Exercise vs Income
05:53 – Story #5: Phytonutrients & Gut Enzymes
07:45 – Dirty Dozen & Clean Fifteen
08:46 – Story #6: Thorne Acquisition
09:49 – Takeaway
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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Carnivore Diet, Cholesterol, Gut Bacteria, Microbiome, and Fasting Insulin Results from a 90-Day Self-Experiment
What if cutting out fiber entirely actually improved your gut bacteria? This episode breaks down a real 90-day carnivore self-experiment, complete with before and after blood work, stool testing, and continuous glucose data, that challenges everything you think you know about fiber, cholesterol, and metabolic health.
Watch this episode on YouTube for the full video experience:
https://www.youtube.com/@DaveAspreyBPR
Host Dave Asprey sits down with Ben Azadi, founder of Keto Kamp and bestselling author of Metabolic Freedom. After overcoming obesity and severe health challenges, Ben has spent years educating millions of people on metabolic health, fasting, ketosis, and biohacking strategies through his podcast, books, and YouTube channel with over a million subscribers. He is known for turning complex science into practical tools anyone can use to burn fat, boost human performance, and support long-term longevity.
Ben walks through what happened when he ate nothing but meat, eggs, and dairy for 90 straight days, tracking everything from his microbiome diversity to his LDL particle size. His cholesterol numbers spiked, but the full lipid panel tells a very different story than most doctors would assume. They get into why ketosis works better when you cycle in and out of it, how sodium and electrolytes play a bigger role in insulin resistance than most people realize, and why eating 17 to 23 times a day might be quietly wrecking your metabolism.
The conversation also covers the real science behind creatine absorption, why Dave adds his to hot coffee for better brain uptake, the truth about cooking oils and smoke points, and why cold plunging is one of the most misunderstood biohacks in the wellness space. Dave and Ben dig into mitochondria, fasting protocols, sleep optimization, and the supplements that actually move the needle for energy, fat loss, and anti-aging.
This is essential listening for anyone serious about biohacking, functional medicine, brain optimization, and building a body that performs at a higher level for longer.
You'll Learn:
What 90 days of zero fiber actually did to his gut bacteria and microbiome diversity Why his cholesterol went up but his cardiovascular risk markers stayed low The real reason cyclical ketosis works better than staying in ketosis full time How sodium and electrolyte intake affects insulin resistance and metabolism Why eating too frequently keeps your body stuck in glucose and insulin spikes The creatine hack that increases brain absorption using hot coffee Why cold plunging is overrated for most people who skip the hormesis basicsThank you to our sponsors!
- PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off.
- ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.
- Timeline | Visit timeline.com/dave to learn more about Mitopure and get 20% off your first order for a limited time.
- ENERGYbits | If you want a simpler, smarter way to support your body… this is it. Head to ENERGYbits.com and use code ASPREY for 20% off your order.
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.
New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.
Keywords: Ben Azadi, Keto Kamp, carnivore diet, 90-day carnivore experiment, gut microbiome, gut bacteria diversity, fiber-free diet, LDL particle size, cyclical ketosis, fasting, autophagy, electrolytes, sodium intake, insulin resistance, fasting insulin, creatine, blood-brain barrier, melatonin, mitochondria, hormesis, cold plunge, dopamine receptors, olive oil polyphenols, smoke point, beef tallow, seed oils, HRV, sleep optimization, KetoFlex, Metabolic Freedom
Resources:
• See All Of Ben Azadi's Content At: https://benazadi.com/
• Check Out Ben’s YouTube Channel: https://www.youtube.com/@KetoKamp
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com
Timestamps:
00:00 – Trailer
01:15 – 90-Day Carnivore Experiment
04:43 – Cholesterol & Lipid Results
09:12 – Cyclical Keto Approach
20:19 – Reading Body Signals
26:36 – Danger Creatine Launch
31:55 – Calories vs. Hormones
33:53 – Root Cause of Insulin Resistance
35:37 – Sodium & Electrolytes
45:11 – Sleep Optimization
49:19 – Cold Plunging Overrated
51:17 – BICEP & Dopamine Reset
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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Your Hormones Are Killing You: Oxytocin, FSH, and the Anti-Aging Protocol Most Doctors Ignore
Your hormones are running your love life, your intuition, your longevity, and your brain, and most doctors are getting it completely wrong. Host Dave Asprey sits down with triple board-certified OBGYN Dr. Anna Cabeca to break down the clinical science of oxytocin, female pleasure, hormonal optimization, and why fixing your hormones can make your 70s the best decade of your marriage.
Dr. Anna Cabeca is a triple board-certified OBGYN and fellow of gynecology and obstetrics, integrative medicine, and anti-aging and regenerative medicine, with additional board certifications in functional medicine, sexual health, and bioidentical hormone replacement therapy. She is the bestselling author of The Hormone Fix, Keto-Green 16, and MenuPause, and has spent decades researching the clinical intersection of oxytocin, cortisol, estrogen, and progesterone on women's hormonal health, metabolism, and longevity. Her work on keto-green nutrition, vaginal and bladder microbiome health, and bioidentical hormone replacement has made her one of the most credentialed and clinically experienced voices in women's functional medicine practicing today.
Dave and Dr. Anna break down the real pharmacology of oxytocin, including its role in muscle regeneration, cortisol suppression, mitochondrial signaling, and vagal tone optimization. They expose the toxic ingredients hiding in mainstream lubricants and vaginal hormone creams, including aspartame, parabens, and petroleum derivatives, and explain why the vaginal microbiome is a frontline organ for women's metabolism and anti-aging. They get into the neuroscience of orgasm, pineal gland activation, endogenous DMT release, and the neurochemical cascade behind peak altered states. Dr. Anna also breaks down the Women's Health Initiative disaster, the FDA's recent reversal on bioidentical hormone replacement, and why FSH is a critical and widely overlooked longevity biomarker. High post-menopausal FSH drives neuroinflammation, accelerates bone loss, and degrades brain optimization outcomes, and most physicians are not testing for it.
This is essential listening for anyone serious about biohacking, longevity, anti-aging, functional medicine, human performance, brain optimization, and taking full ownership of their biology.
You'll Learn:
Why oxytocin functions as a regenerative hormone that rebuilds muscle, suppresses cortisol, and supports mitochondria signaling What toxic chemicals are hiding in standard lubricants and vaginal hormone creams and what to use instead How orgasm activates the pineal gland and triggers endogenous DMT release and altered neurological states Why female intuition may be directly linked to mitochondrial density concentrated in the ovaries How elevated FSH drives neuroinflammation, bone loss, and accelerated brain aging in post-menopausal women Why the FDA reversed 30 years of flawed guidance on bioidentical hormone replacement therapy How four days of sensory deprivation supercharges melatonin, oxytocin, and endogenous DMT production Why oxytocin combined with ketamine is being used clinically to break trauma patterns and rewire neural pathways How polyphenols, CoQ10, carnitine, and vagal tone training protect cardiovascular health and support longevity Why polypharma accelerates decline and what functional medicine does differentlyThank you to our sponsors!
- KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off
- Gatlan | Book your free consultation at www.gatlan.com/DAVE
- Redmond Real - Leaf Toothpaste | Go to https://redmond.com/asprey and use code ASPREY for 15% off your first order.
- Neuronic | Go to www.neuronic.online Code DAVE for $100 off
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.
New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.
Keywords: Dr. Anna Cabeca, The Girlfriend Doctor, oxytocin, bioidentical hormone replacement, FSH, follicle-stimulating hormone, vaginal microbiome, Velve lubricant, Julva, Mighty Maca, cortisol suppression, pineal gland, DMT, neuroinflammation, broken heart syndrome, NT-proBNP, vagal tone, dark retreat, orgasmic meditation, Women's Health Initiative, perimenopause, postmenopause, yoni massage, oxytocin nasal spray, cabergoline, prolactin, Pitocin, CoQ10, carnitine, Arterosil, polypharma, keto-green, The Hormone Fix
Resources:
• Get An Exclusive Offer On Dr. Anna’s Products At: dranna.com/tribe
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com
Timestamps:
00:00 – Trailer
01:37 – What Is Oxytocin?
07:38 – Clean Lube Launch
09:11 – Toxic Lube Ingredients
17:08 – Oxytocin Prescribing
18:58 – FDA Reverses HRT Warning
26:50 – Dark Retreat & DMT
32:15 – Orgasmic Meditation
42:06 – Female Intuition
46:21 – Broken Heart Syndrome
51:15 – FSH & Hormone Monitoring
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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You already know something has changed - the energy crashes, the slow recovery, the brain fog that wasn't there ten years ago. Most people assume that's just aging. But it’s NOT. Nobel Prize-winning research has identified a single molecule that controls how fast your body breaks down, and more importantly, exactly why yours is being destroyed faster than it's being rebuilt. The fix isn't complicated, but the order you do it in matters. In this video, Dave breaks down what this molecule is, why your body is actively working against it, and the exact protocol (diet, fasting, exercise, and supplementation) to restore it before the gap gets any wider.
Thank you to our sponsors!
Gatlan | Book your free consultation at www.gatlan.com/DAVEViome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:
0:00 – The Longevity Switch
0:47 – Why Mitochondria Matter
2:28 – What Mitophagy Is
2:46 – How Mitophagy Works
4:18 – What Shuts It Off
8:54 – The Damage Compounds
9:22 – How to Turn It Back On
10:31 – Signal 1: Fasting
11:48 – Signal 2: Exercise (REHIT)
12:30 – Signal 3: Cold Exposure
13:22 – Signal 4: NAD+
14:29 – Signal 5: Urolithin A and Spermidine
Connect with Dave Asprey!
Website: https://daveasprey.com
TikTok: https://www.tiktok.com/@daveaspreyofficial
Instagram: https://www.instagram.com/dave.asprey/
Facebook: https://www.facebook.com/Daveaspreyofficial/
X: https://x.com/daveasprey
YouTube: https://www.youtube.com/c/daveaspreybpr
The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/
Danger Coffee: https://dangercoffee.com/DAVE15
Dave Asprey’s BEYOND Conference: https://beyondconference.com/
Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15
Upgrade Labs: https://upgradelabs.com
40 Years of Zen: https://40yearsofzen.com
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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Fish Oil Supplements And Alzheimer’s-Related Decline
A two-year randomized, double-blind, placebo-controlled trial led by researchers at USC tested whether 2,000 mg of DHA fish oil daily could slow Alzheimer’s-related brain changes in 365 adults ages 55–80 who rarely consumed fish and had at least one Alzheimer’s risk factor. Researchers confirmed the supplement reached the brain by measuring a roughly 17% increase in cerebrospinal fluid DHA after six months. Despite successfully increasing brain DHA levels, participants taking fish oil showed no significant improvements in memory, global cognitive function, or hippocampal volume compared to placebo after two years. Host Dave Asprey explains why raising a single biomarker doesn’t always translate into better brain performance, why nutrition works differently inside a complete dietary pattern than as an isolated supplement, and what this study means for anyone relying on fish oil as an Alzheimer’s prevention strategy.
Sources:
https://medicalxpress.com/news/2026-06-fish-oil-supplements-alzheimer-decline.pdf
https://www.cnn.com/2026/06/18/health/omega-3-fish-oil-algae-supplement-wellness
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DASH Diet Showed the Strongest Link to Long-Term Brain Health
Researchers from Harvard analyzed dietary data from 159,347 participants across three long-running U.S. health studies to examine how eating patterns influence cognitive aging. Participants completed dietary questionnaires every four years over several decades, allowing investigators to compare six healthy dietary patterns, including the DASH and Mediterranean diets. While all six were associated with better cognitive health later in life, adherence to the DASH diet produced the strongest association, with participants showing roughly a 40% lower risk of subjective cognitive decline and stronger performance on objective cognitive testing. The protective relationship was strongest when healthy eating habits began during midlife. Host Dave Asprey breaks down why blood sugar control, lower inflammation, and healthier blood vessels may be the real drivers behind long-term brain resilience, and why your dietary choices in your 40s and 50s may have an outsized impact on cognitive aging decades later.
Sources:
https://jamanetwork.com/journals/jamaneurology/article-abstract/2845466
https://www.health.harvard.edu/diet-and-nutrition/harvard-study-six-healthy-diets-linked-with-better-long-term-brain-health
https://www.eurekalert.org/news-releases/1117225
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Scientists Identified an Ancient Brain Circuit That Filters Distractions
Johns Hopkins researchers discovered a small population of inhibitory neurons within an evolutionarily ancient brainstem region that appears to control selective attention by determining which sensory information deserves focus and which distractions should be ignored. Mice trained on visual attention tasks consistently ignored irrelevant stimuli until researchers temporarily silenced these neurons, causing even weak distractions to hijack their attention while leaving vision and movement otherwise unaffected. Similar brain circuits exist in birds, reptiles, and other vertebrates, suggesting this attentional filtering system evolved long before the modern human cortex. Host Dave Asprey explains why attention may depend on much older brain circuitry than previously believed, how this discovery could reshape our understanding of ADHD and autism, and why future therapies may target the brainstem instead of the prefrontal cortex.
Sources:
https://www.sciencedaily.com/releases/2026/06/260624025426.htm
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Nearly Half of Older Adults Improved With Age Instead of Declining
A Yale-led study followed 11,340 adults age 65 and older for up to 12 years using repeated measurements of cognition and walking speed to better understand how aging changes over time. Rather than finding universal decline, researchers discovered that 45% of participants improved in either cognitive function, physical performance, or both. Nearly one-third experienced measurable cognitive improvements, while over one-quarter improved physically. Researchers also found that participants with more positive beliefs about aging were significantly more likely to improve, even after accounting for education, chronic illness, depression, and other health factors. Host Dave Asprey explores why expectations about aging may become biologically embedded, why decline is far less inevitable than conventional medicine often assumes, and how mindset may directly influence healthy longevity.
Sources:
https://www.sciencedaily.com/releases/2026/06/260620100428.htm
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Glyphosate May Be Contributing to Antibiotic-Resistant Superbugs
Researchers publishing in Frontiers in Microbiology examined 102 bacterial strains collected from hospitals, agricultural land, and protected wetlands to investigate whether glyphosate exposure contributes to multidrug antibiotic resistance. Hospital bacteria demonstrated extensive resistance to both antibiotics and glyphosate, while even bacteria living inside protected nature reserves displayed measurable glyphosate resistance despite no direct herbicide application. Genetic analysis suggested resistant bacterial strains may move between agricultural environments and hospitals through shared waterways and sediments. The researchers argue pesticide safety testing should also evaluate whether chemicals encourage antibiotic resistance, one of the world’s fastest-growing public health threats. Host Dave Asprey explains why environmental toxins may have unintended effects on the human microbiome, how herbicides could influence antimicrobial resistance beyond farming, and why environmental biology increasingly belongs in conversations about human health.
Sources:
https://www.sciencedaily.com/releases/2026/06/260620100434.htm
https://www.openaccessgovernment.org/common-weedkiller-glyphosate-linked-to-rise-in-superbugs-scientists-warn/207515/
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Butterflies That Barely Age Could Unlock New Longevity Pathways
Researchers from the University of Bristol found that Heliconius butterflies live dramatically longer than closely related butterfly species while aging much more slowly. In one comparison, Heliconius hewitsoni survived up to 348 days, while a closely related species lived only 14 days. Unlike most butterflies, Heliconius feed on pollen throughout adulthood, providing amino acids that help preserve muscle function and physical performance with age. However, even when pollen was removed, these butterflies still significantly outlived their relatives, suggesting evolved genetic and metabolic mechanisms also contribute to their exceptional longevity. Host Dave Asprey explores why nature continues to provide unexpected models for slowing biological aging, what scientists hope to learn from species that naturally maintain function over time, and how comparative biology may uncover entirely new pathways for extending human healthspan.
Sources:
https://www.sciencedaily.com/releases/2026/06/260622014302.htm
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This episode is designed for biohackers, longevity enthusiasts, and high-performance listeners who want mechanism-level insights into omega-3 supplementation and Alzheimer’s prevention, nutrition strategies for preserving cognitive health, newly discovered brain circuits controlling attention, the surprising biology behind healthy aging, environmental drivers of antibiotic resistance, and what one remarkably long-lived butterfly can teach us about extending healthspan. Host Dave Asprey connects randomized clinical trials, large population studies, neuroscience discoveries, microbiology research, and evolutionary biology into practical frameworks for improving brain performance, resilience, and longevity.
New episodes every Tuesday, Thursday, Friday, and Sunday.
Keywords: fish oil Alzheimer’s study, DHA supplements memory, omega-3 brain health, DASH diet cognition, dementia prevention diet, cognitive decline nutrition, selective attention brainstem, focus neuroscience, ADHD brain research, positive aging beliefs, healthy aging study, cognitive improvement older adults, glyphosate antibiotic resistance, superbugs glyphosate, environmental toxins microbiome, butterfly longevity research, Heliconius aging, longevity science, biohacking news 2026, Dave Asprey, The Human Upgrade
Thank you to our sponsors!
- Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off today
- Neuronic | Go to www.neuronic.online Code DAVE for $100 off
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Resources:
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com
Timestamps:
00:00 – Intro
00:18 – Story #1 Fish Oil
02:31 – Story #2 DASH Diet
03:49 – Story #3 Brain Stem Attention Filter
05:59 – Story #4 Cognitive Decline Lies
08:24 – Story #5 Glyphosate
10:16 – Story #6 Butterfly Lifespan Research
12:16 – Biohacking Criticism Response
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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Most energy drinks trade your long-term health for a short-term jolt. This episode breaks down a smarter approach to energy, one that builds mitochondria function, supports gut health, stabilizes mood, and helps you sleep better at night, all without the crash
-Get 15% off your next order at: https://getmte.com/dave
Host Dave Asprey sits down with Jeff Boyd, founder and chairman of MTE (More Than Energy), the caffeine-free energy drink built around adaptogens, nootropics, and prebiotics that delivers what Boyd calls "energy that loves you back." Before launching MTE, Jeff spent 15 years as President and co-owner of Luggage Free, scaling the company to operations in over 100 countries before selling it in 2019. He brings the operational discipline of a veteran entrepreneur and the personal conviction of someone who built the energy product he actually wanted to exist.
Dave and Jeff get into the full science and strategy behind MTE's ingredient stack, including paraxanthine, ashwagandha, eleuthero, maca, GABA, theanine, and saffron, and why each one was chosen for its role in stress response, brain optimization, and sleep optimization. They also dig into the formulation challenges of building a clean-label supplement over a stimulant base, the real difference between caffeine and its downstream metabolite paraxanthine, and why this blend functions more like a foundational biohacking protocol than a beverage.
You'll Learn:
Why conventional energy drinks wreck your cortisol curve and what to do instead How paraxanthine delivers the benefits of caffeine without the jitters or sleep disruption The adaptogen trio (ashwagandha, eleuthero, and maca) and how they work together for stress response and human performance Why saffron is one of the most underrated nootropics for mood and brain optimization How gut health and the microbiome connect directly to your energy, metabolism, and longevity The mitochondria connection between willpower, physical performance, and entrepreneurial output How AI is reshaping small teams and what founders need to do right now to stay competitive Why the cleanest path to anti-aging and longevity starts with how you manage your energy across the dayThank you to our sponsors!
- Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com.
- Gatlan | Book your free consultation at www.gatlan.com/DAVE
- BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle.
- Danger Coffee | Grab yours at DangerCoffee.comand use code DAVEPOD at checkout for 15% off.
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.
New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.
Keywords: Jeff Boyd, MTE, More Than Energy, caffeine-free energy, paraxanthine, adaptogens, ashwagandha, eleuthero, maca, nootropics, saffron, GABA, theanine, prebiotics, gut health, stress response, cortisol management, sleep optimization, huckleberry acai, clean label formulation, stevia Reb A, energy drink alternative, paraxanthine vs caffeine, afternoon energy, Luggage Free, cycling endurance, long jump training, ADHD entrepreneurship, AI small teams, willpower mitochondria
Resources:
• Get 15% off your next order at: https://getmte.com/dave
• Purchase Dr. Fotuhi’s New Book The Invincible Brain: https://a.co/d/0iHCgPpL
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com
Timestamps:
00:00 – Trailer
00:42 – What Is MTE?
03:50 – Ingredients Deep Dive
09:49 – Flavors & Formulation
12:31 – Dave's Caffeine Origin
18:35 – Athletic Identity
22:38 – ADHD & Entrepreneurship
26:43 – AI & Future of Work
30:47 – Willpower & Mitochondria
35:34 – MTE Wrap-Up
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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Longevity, Trauma Recovery, Circadian Health, Ramadan Fasting & Biohacking
Your nervous system may be aging you faster than your diet. Learn how childhood programming, stress, sleep, fasting, resilience, and environment shape longevity, healthspan, metabolism, and human performance, and discover why some of the most powerful upgrades for your biology have nothing to do with supplements, nootropics, or the latest biohacking trends.
-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR
-Learn more about Dr. Abirached’s work at: https://limitlesshuman.ae/
Host Dave Asprey sits down with Dr. Elie Abirached, a Dubai-based longevity and biohacking strategist, Harvard alumnus, founder of Limitless Human, and CEO of Restore Fitness. After being smuggled out of Lebanon during the civil war as a teenager, he built a career helping high performers improve healthspan, resilience, recovery, metabolism, and longevity. Today he is one of the Middle East’s leading voices in biohacking, healthy aging, human performance, sleep optimization, and lifestyle-driven longevity.
Together, they explore why Dubai has become a global hub for biohacking and longevity, how extreme heat, light exposure, fasting, and modern lifestyle habits affect human biology, and why nervous system health may be one of the most overlooked drivers of long-term performance and anti-aging. They also dive into trauma, neuroplasticity, emotional resilience, metabolism, brain optimization, sleep quality, and the hidden programming that shapes your reactions, relationships, and health outcomes.
You’ll discover what the Middle East gets right about health and longevity, why resilience may be one of the most important predictors of healthy aging, and how your environment influences everything from recovery and mitochondria to sleep, energy, and mental performance. This episode offers practical insights for anyone interested in biohacking, human performance, longevity, fasting, sleep optimization, metabolism, brain optimization, emotional resilience, and building a stronger, more adaptable nervous system.
You’ll Learn:
• How childhood experiences and unconscious programming influence longevity, healthspan, and human performance
• Why nervous system regulation may be one of the most powerful anti-aging tools available
• What Dubai’s biohacking community gets right about health, recovery, and longevity
• How fasting, including Ramadan-style fasting, affects metabolism, energy, and performance
• The connection between neuroplasticity, emotional resilience, and brain optimization
• How sleep optimization impacts mitochondria, recovery, aging, and cognitive function
• Why environmental factors like heat, light exposure, air quality, and circadian rhythm matter more than most people realize
• How to improve healthspan without relying solely on supplements, nootropics, ketosis, or the latest biohacking trends
• Why stronger biology creates better decision-making, relationships, and long-term success
• Practical strategies for building resilience in a world filled with stress, distraction, AI, and information overload
Thank you to our sponsors!
- Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.
- Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE
- Cowboy Colostrum | Get your gut right by going to cowboycolostrum.com/asprey for 25% off of your entire order.
- Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com. Use code DAVE30 for 30% off.
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.
New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.
Keywords: Dr. Elie Abirached, Dubai biohacking, UAE longevity, Middle East biohacking, Lebanon civil war survivor, resilience training, childhood trauma, nervous system regulation, emotional resilience, neuroplasticity, longevity medicine, healthy aging, human performance, sleep optimization, circadian rhythm, Ramadan fasting, intermittent fasting, metabolism optimization, stress adaptation, biological aging, mitochondria health, environmental health, heat adaptation, Dubai longevity, Limitless Human, Restore Fitness, healthspan, recovery optimization, biohacking Dubai, trauma and longevity
Resources:
• Learn more about Dr. Abirached’s work at: https://limitlesshuman.ae/
• Order Dr. Abirached’s Book ‘Limitless Human’: https://a.co/d/0cwoQFRH
• Purchase Dr. Fotuhi’s New Book The Invincible Brain: https://a.co/d/0iHCgPpL
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com
Timestamps:
00:00 – Trailer
00:50 – War Zone Childhood
04:52 – Dubai Mission
08:08 – Childhood Trauma Programming
13:59 – Biohacking in Extreme Heat
19:37 – Fasting & Ramadan
25:15 – Closing
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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Try TrueDark glasses: https://truedark.com
Try Danger Coffee: https://dangercoffee.com/
Try Suppgrade Labs: https://shopsuppgradelabs.com/
If you're eating clean, taking the right supplements, and still feel exhausted and mentally foggy - the problem isn't your protocol. Your body has a built-in cellular cleanup system that determines whether any of those inputs actually work, and right now it's almost certainly switched off. In this video, I break down what that system is, how chronic stress and all-day eating suppress it without you ever feeling it, and the specific compounds that flip the longevity switch back on through independent biological pathways that nothing else touches.
Thank you to our sponsors!
ECHO Water | Go to http://echowater.com/daveand use code DAVE10 for 10% off your ECHO Flask.EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off.iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:
0:00 – The Longevity Switch
0:47 – Why Mitochondria Matter
2:28 – What Mitophagy Is
2:46 – How Mitophagy Works
4:18 – What Shuts It Off
8:54 – The Damage Compounds
9:22 – How to Turn It Back On
10:31 – Signal 1: Fasting
11:48 – Signal 2: Exercise (REHIT)
12:30 – Signal 3: Cold Exposure
13:22 – Signal 4: NAD+
14:29 – Signal 5: Urolithin A and Spermidine
Connect with Dave Asprey!
Website: https://daveasprey.com
TikTok: https://www.tiktok.com/@daveaspreyofficial
Instagram: https://www.instagram.com/dave.asprey/
Facebook: https://www.facebook.com/Daveaspreyofficial/
X: https://x.com/daveasprey
YouTube: https://www.youtube.com/c/daveaspreybpr
The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/
Danger Coffee: https://dangercoffee.com/DAVE15
Dave Asprey’s BEYOND Conference: https://beyondconference.com/
Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15
Upgrade Labs: https://upgradelabs.com
40 Years of Zen: https://40yearsofzen.com
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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Sugar-Free Diets Disrupted Gut Microbiome and Metabolism
A 16-week sucrose-free, low-fat diet study presented at ENDO 2026 found mice developed insulin resistance, impaired glucose tolerance, gut microbiome imbalance, intestinal inflammation, and fatty liver disease signs despite no weight gain or calorie difference. Host Dave Asprey breaks down why eliminating sugar entirely may be more detrimental than previously thought, the gut-bacteria-to-metabolism cascade that explains the metabolic damage, and why balanced nutrition matters more than simply removing sugar from your stack.
Sources:
https://www.sciencedaily.com/releases/2026/06/260614011843.htm
https://www.medicalnewstoday.com/articles/how-eliminating-sugar-may-alter-the-gut-microbiome-mouse-study
https://nypost.com/2026/06/13/health/going-sugar-free-can-mess-with-your-gut-and-metabolism/
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Taurine Did Not Boost Acute Aerobic Performance
A randomized, triple-blind, cross-over study of 16 physically active young adults found acute 1-gram taurine ingestion one hour before exercise produced no significant improvements in peak oxygen consumption, time to exhaustion, respiratory compensation point, or lipid/glycolytic metabolism variables. Host Dave Asprey explains why taurine remains popular in energy drinks and pre-workouts despite limited scientific evidence, what dosages and activity types future research should test, and why a reality check on a billion-dollar supplement category is exactly the kind of truth biohackers need.
Sources:
https://pubmed.ncbi.nlm.nih.gov/42268287/
https://www.sciencedaily.com/releases/2026/06/260611024609.htm
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Copper Therapy Improved Memory and Reduced Alzheimer’s Proteins in Mice
Lab trials from Monash University published in ACS Chemical Neuroscience found Cu(ATSM), a copper-delivery compound, increased P-glycoprotein abundance by 24.1 percent at the blood-brain barrier, reduced toxic amyloid-beta by 42 percent over 56 days, and improved spatial learning by nearly 44 percent in an Alzheimer’s mouse model. Host Dave Asprey breaks down why repairing the brain’s waste-clearing pump is a potential new therapeutic avenue for neurovascular dysfunction, why Cu(ATSM) has strong potential to fast-track into human clinics since it’s already tested for Parkinson’s and ALS, and why biometal therapies like this could be the next frontier in Alzheimer’s treatment.
Sources:
https://www.news-medical.net/news/20260615/Lab-trials-prove-copper-therapy-enhances-cognitive-function-and-spatial-learning.aspx
https://www.monash.edu/news/articles/copper-drug-restores-memory-and-clears-toxic-alzheimers-proteins
https://pubs.acs.org/doi/10.1021/acschemneuro.6c00252
~~
Socioeconomic Factors Biologically Embedded in Children’s Brains
A study of 2,300+ 9- and 10-year-olds published in Science found socioeconomic factors—household income, education, neighborhood quality—were the dominant variable affecting brain development, with MRI-visible differences in sensory processing and motor control regions linked to less sleep, more stress, and higher social media use in lower-income neighborhoods. Host Dave Asprey explains why socioeconomics became “biologically embedded” in preteen brains, how sleep-stress-screen circuits alter wakefulness and alertness, and why earlier studies focusing on IQ or mental health without accounting for environment may require reevaluation.
Sources:
https://www.npr.org/2026/06/11/nx-s1-5849937/child-brain-development-stress-sleep-neighborhood-economics
https://abcdstudy.org/
~~
Strength Training Sweet Spot for Longevity Is 90–120 Minutes Per Week
A 30-year observational study of 147,374 participants published in the British Journal of Sports Medicine found 90–119 minutes per week of strength training delivered 13 percent lower all-cause mortality, 19 percent lower cardiovascular mortality, and 27 percent lower neurological mortality, with no additional benefit above 120 minutes. Host Dave Asprey breaks down why more isn’t always better when it comes to resistance training, why combining strength with aerobic exercise dropped mortality risk by 45–58 percent at highest levels, and why 15–20 minutes a day or 30–40 minutes three times weekly is the minimum effective dose for longevity.
Sources:
https://www.sciencedaily.com/releases/2026/06/260611024609.htm
https://academic.oup.com/sleep/article/48/8/zsaf127/8129074
https://www.bmj.com/content/bsjspor/early/2025/06/11/bjsports-2025-110503
~~
This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on sugar-free diet metabolic risks, taurine supplement efficacy, copper-based Alzheimer’s therapeutics, childhood environmental brain development, and strength training longevity dosing. Host Dave Asprey connects preclinical animal data, randomized human trials, observational cohort research, and population neuroscience into actionable frameworks for extending healthspan, optimizing metabolism, and staying ahead of the science.
New episodes every Tuesday, Thursday, Friday, and Sunday.
Keywords: sugar-free diet gut microbiome, insulin resistance sugar elimination, taurine aerobic performance, taurine supplement myths, Cu(ATSM) copper Alzheimer’s therapy, blood-brain barrier P-glycoprotein, amyloid-beta reduction copper drug, spatial learning Alzheimer’s mouse, socioeconomic brain development children, ABCD Study brain MRI, childhood biohacking environment, strength training longevity 90-120 minutes, British Journal Sports Medicine strength, weekly strength training dose, all-cause mortality resistance training, biohacking news 2026, longevity research
Thank you to our sponsors!
- Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.
- Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com.
- iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE
Resources:
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com
Timestamps:
0:00 – Intro
0:20 – Story 1: Copper & Alzheimer's
2:42 – Story 2: Sugar-Free Diet
4:05 – Story 3: Strength Training Minimum Dose
5:48 – Story 4: Childhood Environment & Brain Development
7:42 – Story 5: Taurine
9:49 - Takeaways
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
-
Ketamine Therapy, MDMA, Psilocybin, and the Science of Psychedelic Assisted Healing
Most people struggling with depression, anxiety, and trauma have never felt safe in their nervous system, and the treatments they have been prescribed are making that worse. This episode breaks down the neuroscience of psychedelic therapy, why ketamine is the safest and most accessible starting point, how MDMA triggers a BDNF dependent pathway that repairs trauma all the way down to the epigenetic code, and why your antidepressant may be blocking the very brain states required for real healing.
-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR
-Order Dr. Rabin’s Book ‘A Simple Guide to Being Alive’: https://apolloneuro.com/pages/a-simple-guide-to-being-alive
Host Dave Asprey sits down with Dr. Dave Rabin, MD, PhD, a senior research scientist at the Florida Institute for Human and Machine Cognition, Executive Director of The Board of Medicine, and co-founder and Chief Medical Officer of Apollo Neuroscience. Dr. Rabin received his MD and PhD in neuroscience from Albany Medical College and specialized in psychiatry at the University of Pittsburgh Medical Center. He has spent 20 years studying chronic stress and non-invasive therapies for treatment-resistant illness, and his primary research on MDMA assisted therapy for severe PTSD has demonstrated that trauma can be reversed at the epigenetic level, offering a genuine path to a cure. His upcoming book A Simple Guide to Being Alive publishes June 1, 2026 and is a science-backed manual for anyone who has ever felt overwhelmed by the modern world.
Dave and Dr. Rabin break down why nearly 50% of people prescribed psychiatric medication never achieve remission, why SSRIs and SNRIs physically block the brain states required for emotional healing, and why the FDA rejected MDMA therapy after three trials showed an 88% response rate. They dig into the exact BDNF pathway that makes MDMA and ketamine so transformative, how psychedelics amplify safety learning in the amygdala at the molecular level, and why trauma passes down up to 14 generations through epigenetic code that can now be measured and repaired. They also cover why your breathing rate at the doctor's office is already a stress signal nobody is reading, how your smartphone puts your nervous system into a chronic fear state before you even get out of bed, and why ketamine is the right starting point for anyone curious about psychedelic therapy right now.
You'll Learn:
Why nearly 50% of psychiatric patients never get better and what treatment-resistant actually means How ketamine therapy works, why it is legal in every state, and why it is the safest place to start The exact BDNF pathway through which MDMA repairs fear extinction in the amygdala How MDMA assisted therapy produces measurable epigenetic repair of the cortisol receptor gene damaged by trauma Why SSRIs and SNRIs block the insula mediated brain states required for real emotional healing Why combining serotonergic psychedelics with SSRIs puts you at risk of life-threatening serotonin syndrome Why trauma passes down up to 14 generations and what you can do to stop the cycle now Why smartphones put your nervous system into a toxic overstimulation state before the day even starts How the FDA rejected MDMA therapy after 88% of patients responded and who paid to make that happenThank you to our sponsors!
- Qualia | If you want to take the guesswork out of maintaining high NAD+ levels as you age, go to www.qualialife.com/daveNAD to get clinically proven Qualia NAD+ backed by a 100 day money back guarantee and code DAVENAD at checkout gets you an extra 15% off.
- iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE
- OneSkin | For a limited time, try OneSkin with 15% off at oneskin.co/DAVE.
- LMNT | Right now you can get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at drinkLMNT.com/dave
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.
New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.
Keywords: Dave Rabin, Dr. Dave Rabin, Apollo Neuroscience, A Simple Guide to Being Alive, ketamine therapy, MDMA assisted therapy, psilocybin therapy, psychedelic assisted therapy, treatment-resistant depression, treatment-resistant mental illness, BDNF pathway, fear extinction amygdala, vagus nerve activation, trauma epigenetics, cortisol receptor gene, epigenetic repair, serotonin syndrome, SSRI alternatives, MDMA BDNF, ketamine BDNF, nervous system safety, autonomic nervous system, parasympathetic nervous system, generational trauma, trauma self-trust, MAPS MDMA trial, FDA MDMA rejection, pharmaceutical interference MDMA, breathing rate stress, smartphone nervous system, Apollo Neuro wearable, Board of Medicine, theboardofmedicine.org, insula cortex, psychedelic safety protocol, ketamine legal therapy, MDMA 88 percent, bottom-up learning psychedelics, trauma fractured self-trust, 14 generations trauma, stress breathing range
Resources:
• Order Dr. Rabin’s Book ‘A Simple Guide to Being Alive’: https://apolloneuro.com/pages/a-simple-guide-to-being-alive
• Purchase Dr. Fotuhi’s New Book The Invincible Brain: https://a.co/d/0iHCgPpL
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com
Timestamps:
00:00 – Trailer
01:34 – Dave Rabin Introduction
05:01 – Psychedelics and Psychiatry
08:35 – Psychedelic Safety and Dosing
14:53 – Serotonin Syndrome Warning
21:17 – Vagus Nerve and Safety
27:36 – Smartphones and Chronic Stress
34:18 – Defining Trauma
38:00 – Trauma and Epigenetics
40:23 – MDMA Cortisol Gene Repair
44:44 – Therapy vs. Medicine Alone
49:15 – FDA MDMA Rejection
55:35 – Ketamine Personal Experience
59:15 – Closing and Book Recommendation
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
-
Skin Cancer Prevention, Anti-Aging Biohacking, and the Melanoma Detection Gap
Most dermatologists are missing melanoma, and a board-certified skin cancer specialist explains exactly why, and what to do about it. This episode covers the detection tool that finds 10 times more melanomas, the real truth about sunscreen chemicals, the biohacking peptide that can hide cancer on your skin, and the cheap anti-aging drug that most people have never tried.
-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR
Host Dave Asprey sits down with Dr. Michael Christopher, a board-certified dermatologist and expert dermoscopist recognized for his work in early melanoma detection. Through consistent, evidence-based use of dermoscopy, he identifies between 150 and 215 melanomas annually, far exceeding national and state averages and exposing a critical gap in standard skin cancer screening. Dr. Christopher speaks regularly on prevention, early detection, and systemic failures in dermatology training across health, wellness, and longevity-focused media, and has made it his mission to change the standard of care before more people die from a cancer that is almost always curable when caught early.
Dave and Dr. Christopher break down why a standard skin exam with no additional tools is essentially a guess, how dermoscopy changes everything, and why most dermatologists who claim to use it actually cannot interpret what they see. They get into the real risk factors for rising melanoma rates, what sunscreen labels are not telling you, and how melanotan and other biohacking peptides interact with your skin cancer risk in ways that matter. They also cover tretinoin as one of the most evidence-backed anti-aging and skin optimization tools available, how red lighttherapy supports mitochondria function and skin rejuvenation, and what parents should know about protecting their kids' skin for long-term longevity
You'll Learn:
Why most dermatologists miss melanoma and what the detection gap actually looks like What dermoscopy is, how it works, and why you should ask for it by name How melanoma survival drops from 99% at stage one to 73% at stage three What the Prop 65 cancer warning on most pharmacy sunscreens actually means Why visible light can darken your skin even when you wear sunscreen How melanotan activates melanocortin receptors and why that may affect melanoma risk What Retin-A does to collagen, the epidermis, and long-term skin aging How AI is entering dermoscopy and where it still falls short The right concentration of tretinoin to start with and how to get through the adjustment period What parents should do now to protect their kids from melanoma laterThank you to our sponsors!
-Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com.
-Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.
-Timeline | Go to timeline.com/dave and you’ll get an additional 20% off your first month
-Redmond Real - Leaf Toothpaste | Go to https://redmond.com/asprey and use code ASPREY for 15% off your first order.
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.
New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.
Keywords: Michael Christopher, Dr. Michael Christopher, melanoma detection, dermoscopy, dermatoscope, skin cancer screening, melanoma prevention, early melanoma detection, skin cancer biohacking, sunscreen toxins, Prop 65 sunscreen, mineral sunscreen, zinc oxide, titanium dioxide, melanotan, melanocortin, skin aging, anti-aging, tretinoin, Retin-A, retinol, skin rejuvenation, collagen, red light therapy, mitochondria, UV exposure, UVB light, skin cancer longevity, melanoma survival rate, squamous cell carcinoma, functional medicine, human performance, longevity, biohacking, supplements, skin optimization, dermoscopy AI, skin cancer AI, visible light tanning, omega-6 sunburn, astaxanthin, skin health, melanoma staging, skin exam, skin cancer prevention
Resources:
• Learn More About Dr. Christopher’s Work At: https://www.instagram.com/michael_christopher_md/
• Purchase Dr. Fotuhi’s New Book The Invincible Brain: https://a.co/d/0iHCgPpL
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com
Timestamps:
0:00 – Trailer
1:41 – Guest Introduction
3:59 – Dermatoscope Explained
12:27 – Melanoma Rising: Why
16:57 – Melanotan & Sun Risk
21:14 – Melanoma & Longevity
22:31 – Stage 1 vs Stage 3
26:05 – Retin-A Deep Dive
38:53 – Loose Skin Solutions
41:26 – Kids' Skin Health
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
-
Try TrueDark glasses: https://truedark.com
Try Danger Coffee: https://dangercoffee.com/
Try Suppgrade Labs: https://shopsuppgradelabs.com/
Over the last 15 years, I’ve built companies and spent millions testing what actually upgrades human performance, and I can tell you that mental fatigue has absolutely nothing to do with willpower. In this video, I break down the exact neurochemistry of deep focus. When your brain runs out of dopamine, norepinephrine, and acetylcholine, or gets bogged down by oxidative stress, your executive function collapses. The pharmaceutical industry wants you hooked on expensive stimulants that only treat the symptoms, but the real biological fix is a common antioxidant: Vitamin C.
I explain how your brain hoards Vitamin C at levels 100 times higher than your blood, how to bypass the blood-brain barrier using SVCT2 transporters, and why eating sugar before you take it completely blocks its absorption. You'll also learn the exact biohacking stack—including NAC, CoQ10, PQQ, and L-theanine—you need to recycle this molecule, protect your mitochondria, and maintain effortless, razor-sharp focus all day long.
Thank you to our sponsors!
-KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off
-Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.
-iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE
Timestamps:
00:00 – Trailer
00:21 – Focus Is Biology
01:53 – Brain Chemistry Explained
05:33 – Vitamin C Revealed
07:09 – How to Dose
08:18 – Absorption Barriers
09:31 – Optimize Uptake
10:00 – Oxidative Stress Problem
11:00 – Stack for Deeper Focus
Connect with Dave Asprey!
Website: https://daveasprey.com
TikTok: https://www.tiktok.com/@daveaspreyofficial
Instagram: https://www.instagram.com/dave.asprey/
Facebook: https://www.facebook.com/Daveaspreyofficial/
X: https://x.com/daveasprey
YouTube: https://www.youtube.com/c/daveaspreybpr
The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/
Danger Coffee: https://dangercoffee.com/DAVE15
Dave Asprey’s BEYOND Conference: https://beyondconference.com/
Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15
Upgrade Labs: https://upgradelabs.com
40 Years of Zen: https://40yearsofzen.com
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
-
Semaglutide Slows Biological Aging
A randomized, placebo-controlled study published in Nature Communications found semaglutide slowed biological aging markers by nine percent on the DunedinPACE epigenetic clock in adults living with HIV-associated metabolic disease, with simultaneous improvements across inflammation, heart, kidney, liver, and brain markers. Host Dave Asprey breaks down why this isn't a weight loss story. It's a metabolic inflammation story. He explains why the GLP-1 mechanism hitting insulin signaling, oxidative stress, and inflammatory pathways simultaneously is the real finding, and makes the case that your metabolic markers and your aging markers are the same numbers.
Sources:
https://www.medicalnewstoday.com/articles/glp-1-drugs-ozempic-wegovy-may-slow-biological-aging https://www.nature.com/articles/s41467-026-72861-3 https://today.ucsd.edu/story/study-popular-glp-1-drug-may-slow-down-biological-agingFDA Approves First New Sunscreen Ingredient in 20 Years
The FDA approved bemotrizinol as a permitted OTC sunscreen active ingredient, the first new approval in roughly two decades, clearing it for adults and children six months and older with broad UVA and UVB coverage and low skin absorption. Host Dave Asprey explains why twenty years of regulatory lag left American consumers with inferior chemistry while Europe moved on, why he's watching independent absorption data before updating his own stack, and why consistency of use matters more than perfect formulation when sun protection remains one of the most evidence-backed longevity interventions available.
Sources:
https://www.fda.gov/news-events/fda-newsroom/press-announcements/fda-expands-sunscreen-options-first-time-20-years https://www.accessdata.fda.gov/scripts/cder/omuf/index.cfm?event=OrderDetail&orderid=OTC000039 https://www.usatoday.com/story/news/health/2026/06/09/new-sunscreen-ingredient-bemotrizinol/90477659007/Deoxyribose Gel Matches Minoxidil in Hair Regrowth Study
Researchers testing a topical gel made from deoxyribose, the sugar backbone of DNA, saw roughly 80 to 90 percent hair regrowth in a mouse model of male-pattern baldness, matching minoxidil results and showing new follicle formation and increased blood vessel activity in treated areas. Host Dave Asprey breaks down why mouse hair regrowth studies have a long history of failing to translate to humans, what a plausible circulation-based mechanism would actually need to show in human trial data before it's worth acting on, and why the molecule itself is interesting enough to keep watching.
Sources:
https://www.reddit.com/r/Biohackers/comments/1tyt87w/researchers_found_that_a_gel_made_from/ https://www.sciencealert.com/surprise-hair-loss-breakthrough-a-dna-sugar-gel-sparks-robust-regrowthCaffeinated Chewing Gum and Exercise Performance
A systematic review and meta-analysis of 21 studies found caffeinated chewing gum produces a small but real ergogenic effect for muscular strength and countermovement jump height, with buccal absorption delivering caffeine faster than capsules or drinks in a five to twenty-five minute pre-training window. Host Dave Asprey breaks down why delivery mechanism is an underrated variable in caffeine optimization, why timing matters as much as dose, and why a modest but measurable edge on a cheap and accessible tool is exactly the kind of practical biohack worth understanding.
Sources:
https://pubmed.ncbi.nlm.nih.gov/42228847/ https://doi.org/10.1519/JSC.0000000000005530 https://www.reddit.com/r/Biohackers/comments/1u0acgc/fastacting_caffeine_does_caffeinated_chewing_gum/Vitamin A Overdoses Surge Nearly 40 Percent
Medical News Today reported a 38.7 percent spike in vitamin A overdoses in early 2025, driven by online misinformation claiming high-dose vitamin A treats or prevents measles, a claim with no clinical support and real toxicity risk from fat-soluble accumulation in the liver. Host Dave Asprey explains the actual hepatotoxicity and bone demineralization risks of preformed retinol excess, draws the critical distinction between preformed retinol and beta-carotene that got lost in the misinformation cycle, and makes the case that mechanism is not a dosing protocol and confusing the two is how people get hurt.
Sources:
https://www.medicalnewstoday.com/amp/articles/vitamin-a-overdoses-rose-by-38-7-2025-how-to-get-right-amountWorld Cup 2026 and Mass Gathering Health Risk
With the 2026 FIFA World Cup underway, public health researchers are flagging dense international crowds, high-volume travel, and shared indoor and outdoor spaces as an elevated transmission environment for respiratory illness. Host Dave Asprey reframes the conversation away from germ exposure and toward immune terrain, explains why your resilience going into a high-contact environment is a variable you actually control, and lays out the pre-exposure preparation window that matters most for anyone traveling or attending large events this summer.
Sources:
https://www.healthline.com/health-news/2026-fifa-world-cup-health-risks-protect-yourselfThis episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on GLP-1 aging biology, sunscreen chemistry and regulatory science, emerging hair regrowth research, caffeine delivery optimization, supplement toxicity risk, and immune terrain preparation for mass gathering events. Host Dave Asprey connects randomized clinical data, epigenetic clock research, consumer health regulation, and real-world optimization protocols into actionable frameworks for extending healthspan, sharpening performance, and staying ahead of the science.
New episodes every Tuesday, Thursday, Friday, and Sunday.
Keywords: semaglutide biological aging, GLP-1 epigenetic clock, DunedinPACE aging marker, PCGrimAge mortality risk, bemotrizinol FDA approval, new sunscreen ingredient 2026, UVA UVB broad spectrum sunscreen, deoxyribose hair gel, minoxidil alternative hair regrowth, caffeinated chewing gum performance, buccal caffeine absorption, pre-workout caffeine timing, vitamin A overdose toxicity, preformed retinol hypervitaminosis, fat-soluble vitamin accumulation, World Cup 2026 health risk, immune terrain optimization, mass gathering respiratory illness, biohacking news 2026, longevity research, Dave Asprey, The Human Upgrade
Thank you to our sponsors!
- Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.
- Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com.
- iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE
Resources:
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com
Timestamps:
00:00 – Intro
00:41 – Story 1: Ozempic Slows Aging Clocks
01:53 – Story 2: New Sunscreen Approved
03:12 – Story 3: DNA Sugar & Hair Regrowth
04:38 – Story 4: Caffeine Gum & Performance
06:13 – Story 5: Vitamin A Overdose Spike
07:59 – Story 6: World Cup & Immune Prep
09:34 – Outro
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
-
How to Reverse Cognitive Decline, Grow Your Hippocampus, and Protect Your Brain from Alzheimer's Disease with Nutrition, Exercise, Sleep, and Stress Reduction
Your brain is physically shrinking right now, and most people have no idea it's happening. In this episode, you will discover the exact mechanisms behind cognitive decline, why brain fog is always treatable, and the proven strategies to grow your brain back, protect your memory, and slash your Alzheimer's risk regardless of your genetics.
-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR
Host Dave Asprey sits down with Dr. Majid Fotuhi, a neuroscientist and neurologist who earned his PhD from Johns Hopkins University and his medical degree from Harvard Medical School. He currently serves as an adjunct professor at the Mind/Brain Institute at Johns Hopkins while also teaching at George Washington University and Harvard Medical School. With 37 years of experience in clinical practice, teaching, and neuroscience research, Dr. Fotuhi pioneered the Brain Fitness Program, a multidisciplinary approach to cognitive performance and brain vitality at any age that has produced measurable results documented in peer-reviewed journals. He is the author of three books including the bestselling The Invincible Brain and one of the world's leading experts on neuroplasticity, hippocampus growth, and successful aging. If anyone has earned the right to tell you your brain can get better, it is him.
Dr. Fotuhi and Dave break down why Alzheimer's is not a single disease but a soup of modifiable problems, why your lab results can show "normal" while your brain is starving, and how the five pillars of brain health connect directly to longevity, mitochondria function, and human performance. They also get into the brain effects of GLP-1s, the therapeutic promise of psychedelics like psilocybin and ketamine, the role of nootropics and supplements like B12, lithium orotate, and CoQ10, and why your VO2 max may be the single most important number for brain aging. .
You'll Learn:
Why 97% of Alzheimer's cases involve multiple modifiable causes and what to do about each one How to physically grow your hippocampus through exercise, meditation, and nutrition Why "normal" lab ranges are actively harming millions of people and what optimal actually looks like The 7 everyday things that are shrinking your brain right now How stress, loneliness, and isolation cause measurable brain atrophy Which supplements including B12, lithium orotate, CoQ10, and nootropics support long-term brain health Why VO2 max predicts brain aging better than almost any other marker What psychedelics like psilocybin and ketamine actually do to your brain according to a Johns Hopkins neurologist How the APOE4 gene affects Alzheimer's risk and why exercise can erase that risk entirely Why mitochondria health is the foundation of both brain function and longevityThank you to our sponsors!
- Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.
- BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle.
- Pique | Go to Piquelife.com/dave for 20% off.
- BodyHealth | Visit BodyHeath.com and use code DAVE20 for 20% off your first purchase
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.
New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.
Keywords: Majid Fotuhi, Dr. Majid Fotuhi, The Invincible Brain, brain health, cognitive decline, Alzheimer's prevention, hippocampus, neuroplasticity, brain fog, memory loss, APOE4, brain shrinkage, B12 deficiency, lithium orotate, CoQ10, nootropics, VO2 max, mitochondria, longevity, anti-aging, biohacking, brain optimization, sleep optimization, stress reduction, functional medicine, human performance, psilocybin, ketamine, GLP-1, semaglutide, telomeres, BDNF, brain training, cognitive performance
Resources:
• Learn More About Dr. Fotuhi’s Work At: https://drfotuhi.com/
• Purchase Dr. Fotuhi’s New Book The Invincible Brain: https://a.co/d/0iHCgPpL
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com
Timestamps:
00:00 – Trailer
00:59 – Intro
03:00 – Cannabis & Nicotine
04:15 – Understanding Alzheimer's
05:38 – Five Pillars Explained
07:55 – Best Cognitive Training
09:08 – Brain Size & Growth
12:36 – B12 & Lab Ranges
17:48 – Head-to-Toe Evaluation
24:17 – Sex & Brain Health
25:43 – Loneliness & Isolation
33:59 – ApoE4 Genetics
35:28 – Alzheimer's Declining
48:44 – Lithium & Brain
59:38 – VO2 Max & Fitness
1:06:42 – Psychedelics
1:09:38 – GLP-1s & Brain
1:12:38 – Closing & Action Steps
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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Dr. William Li: Eat to Beat Disease, Extend Longevity, and Hack Your Vascular Health
Your body already has a built-in cancer defense system, and the foods you eat can rival prescription drugs at activating it. In this episode, you'll discover what 720,000 living centenarians reveal about longevity, why microplastics are reaching your brain through your nose, and how your blood vessels hold the real key to biological aging.
-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR
Host Dave Asprey sits down with Dr. William Li, an internationally renowned physician, scientist, and two-time New York Times bestselling author of "Eat to Beat Disease" and "Eat to Beat Your Diet." As President and Medical Director of the Angiogenesis Foundation, Dr. Li's groundbreaking research has led to the development of more than 40 new medical treatments impacting care for over 70 diseases including diabetes, heart disease, blindness, and obesity. His TED Talk, "Can We Eat to Starve Cancer?", has surpassed 11 million views, making him one of the most trusted voices at the intersection of functional medicine and food as medicine science.
Together they dig into the biology of SuperAgers, the vascular markers that predict how long you'll live, and why flow-mediated dilation may be the most underrated biohacking measurement tool available today. Dave shares what happened after four separate gene therapies, including klotho and VEGF, and Dr. Li explains why your metabolism, mitochondria, and gut microbiome show up in the data on every centenarian ever studied. They also get into the microplastic crisis, the cribriform plate pathway that delivers airborne particles directly to your brain, and why your tongue is the first place your body quietly stores fat.
You'll Learn:
What centenarian research reveals about immune function, gut health, and vascular resilience Why 50% of food extracts matched or outperformed cancer drugs in head-to-head angiogenesis testing How microplastics travel through your nose directly to your central nervous system What flow-mediated dilation and pulse wave velocity tell you about your true biological age Why your hind-third tongue fat is an overlooked early warning sign for sleep apnea and metabolism problems What Dave's four gene therapies (klotho, VEGF, follistatin) actually did to his body How the vagus nerve connects gut health to brain optimization, stress resilience, and longevity Why genetics now accounts for roughly half of longevity outcomes, and what that means for the future of gene therapy How to use biohacking tools to compound your health the same way you compound financial returnsThank you to our sponsors!
- Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com.
- Amp | If you're ready to make fitness fit into your life, go to amp.ai to check it out
- Caldera + Lab | A small habit with big results. Go to CalderaLab.com/DAVE and use code DAVE for 20% off your first order.
- Calroy | Go to Calroy.com/DAVE for exclusive discounts on Arterosil HP, Vascanox HP and all Calroy products.
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.
New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.
Keywords: William Li, Dr. William Li, Eat to Beat Disease, angiogenesis, food as medicine, centenarians, SuperAgers, longevity, anti-aging, biohacking, vascular health, flow-mediated dilation, pulse wave velocity, microplastics, cribriform plate, gene therapy, klotho, VEGF, follistatin, mitochondria, metabolism, gut health, vagus nerve, sleep apnea, functional medicine, human performance, brain optimization, cancer prevention, inflammation, immune system
Resources:
• Learn More About Dr. Li’s Work At: https://drwilliamli.com
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com
Timestamps:
00:00 – Trailer
02:33 – William's Background
06:21 – Food vs. Cancer Drugs
14:09 – Gene Therapy
23:50 – Centenarian Research
27:41 – Stress & the Vagus Nerve
37:31 – Vascular Health
42:34 – Microplastics
53:19 – Novel Biomarkers
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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I used to weigh 300 pounds. I tried every restrictive diet, became a vegan, and trained 90 minutes a day for 18 months with absolute zero results. Everything changed when I drank a cup of yak butter tea at 18,300 feet in Tibet. Within 30 seconds, my severe brain fog lifted, and my metabolism completely shifted.
In this video, I break down exactly why adding sugar to your morning coffee is destroying your metabolism, spiking your insulin, and keeping you fat. I explain the hard science behind the alternative: blending "fat cubes" (grass-fed butter) and MCT oil into your coffee. I reveal how this specific combination of butyrate, CLA, and medium-chain triglycerides bypasses traditional digestion to go straight to your liver, instantly converting into ketones for pure brain fuel. You'll learn how eating more fat actually trains your body to burn its own stored fat, allowing me to hit 4.8% body fat at 50 years old with a biological age in my 30s—without hunger, without a 3 PM crash, and without living in the gym.
Thank you to our sponsors!
Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off todayViome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:
0:00 – Intro
00:42 – Pancreatic Cancer Halted by Virus Injection
01:44 – Teens & AI Therapy Chatbots
03:13 – GLP-1 Drugs Cut Breast Cancer Risk
04:30 – Russia's $26B Longevity Program
06:18 – Sauna vs. Cold Plunge
09:10 – Closing
Connect with Dave Asprey!
Website: https://daveasprey.com
TikTok: https://www.tiktok.com/@daveaspreyofficial
Instagram: https://www.instagram.com/dave.asprey/
Facebook: https://www.facebook.com/Daveaspreyofficial/
X: https://x.com/daveasprey
YouTube: https://www.youtube.com/c/daveaspreybpr
The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/
Danger Coffee: https://dangercoffee.com/DAVE15
Dave Asprey’s BEYOND Conference: https://beyondconference.com/
Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15
Upgrade Labs: https://upgradelabs.com
40 Years of Zen: https://40yearsofzen.com
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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Pancreatic Cancer Halted by Virus Injection
Researchers injected an engineered virus directly into pancreatic tumors in three patients — the virus replicated inside malignant cells, triggered an immune response, and stopped tumor growth and spread at an intentionally low early dose. Host Dave Asprey breaks down why oncolytic viruses can do what chemotherapy can't, how the tumor's dense biological wall becomes less of an advantage when a virus can replicate inside it directly, and why a measurable response at a safety dose is the kind of early signal that changes how he's watching this field.
Sources:
https://www.newscientist.com
AI Chatbots and Teen Mental Health
A new survey shows roughly one in five adolescents and young adults are now going to AI chatbots when they feel sad, anxious, nervous, or stressed, with usage heaviest in the 18–21 range. Host Dave Asprey explains why general-purpose language models designed to be engaging are dangerous as a substitute for real mental health support, why false reassurance from a chatbot may make the pipeline to real care harder to reach, and why this is a health systems story masquerading as a tech adoption story — and what parents need to do about it.
Sources:
https://www.nbcnews.com
GLP-1 Drugs Cut Breast Cancer Risk
Penn Medicine published a retrospective analysis of over 111,000 women finding GLP-1 exposure associated with about 35% lower odds of breast cancer in the full cohort and around 30% lower in a matched comparison group. Host Dave Asprey breaks down why this isn't just a weight loss story — it's a metabolic dysfunction story — explains the insulin resistance, inflammation, and hormonal environment mechanisms that may be driving the signal, and makes the case that this finding should be reshaping how oncologists and OBGYNs think about high-risk patients right now.
Sources:
https://www.pennmedicine.org
Putin's $26 Billion Longevity Program
The Wall Street Journal reports that Russia has made anti-aging research a Kremlin-level national priority through a $26 billion program including gene therapy, organ bioprinting, and xenotransplantation, led by Putin's daughter Maria Vorontsova and physicist Mikhail Kovalchuk. Host Dave Asprey breaks down what's geopolitical theater, what's legitimately frontier science, and why the real question is whether any findings will make it out to the broader research community or get locked inside a state program.
Sources:
https://www.wsj.com https://www.france24.com
Sauna vs. Cold Plunge
A landmark Finnish study tracked over 2,300 men for nearly 21 years and found increasing sauna frequency associated with dramatically lower cardiovascular and all-cause mortality — strongest at four or more sessions per week. Host Dave Asprey settles the debate with the actual data, explains what heat shock proteins and cold shock proteins actually are and why the evidence base behind them is nowhere near equivalent, and calls out the wellness marketing presenting early-stage mouse model research as the cold water equivalent of two decades of human mortality outcomes.
Sources:
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2521522
This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on cancer treatment breakthroughs, adolescent mental health and AI, metabolic drivers of disease, geopolitical longevity science, and the real evidence behind popular recovery modalities. Host Dave Asprey connects emerging clinical research, objective epidemiological data, and real-world optimization protocols into actionable frameworks for extending healthspan, sharpening performance, and staying ahead of the science.
New episodes every Tuesday, Thursday, Friday, and Sunday.
Keywords: oncolytic virus pancreatic cancer, engineered virus tumor treatment, AI chatbot teen mental health, adolescent AI emotional support, GLP-1 breast cancer risk, semaglutide cancer prevention, metabolic dysfunction root cause disease, Putin longevity program Russia, New Health Preservation Technologies, anti-aging biotech geopolitics, sauna longevity mortality data, cold plunge cold shock proteins, RBM3 heat shock proteins, sauna vs cold plunge evidence, biohacking news 2026, longevity research, Dave Asprey, The Human Upgrade
Thank you to our sponsors!
- Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off today
- Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade.
- iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE
Resources:
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com
Timestamps:
00:00 – Intro
00:42 – Pancreatic Cancer Halted by Virus Injection
01:44 – Teens & AI Therapy Chatbots
03:13 – GLP-1 Drugs Cut Breast Cancer Risk
04:30 – Russia's $26B Longevity Program
06:18 – Sauna vs. Cold Plunge
09:10 – Closing
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
- Visa fler
