Avsnitt
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Should I try shrooms for science? In part two of three of our series investigating drugs for longevity, I’m putting psilocybin, LSD and DMT under the microscope - and revealing some pretty exciting research that connects psychedelics to longer lifespans. We’ll also talk about weed, and what the data says about marijuana for longevity.
Study Links:
Psilocybin for Cancer Patients
LSD: Longevity in Worms
Cannabis Use Disorder Increases Mortality Risk
Marijuana Increases Epigenetic Aging
Marijuana’s Impacts on Sleep
Improving Sleep with Medical Cannabis
Hosts:
Bryan Johnson: Blueprint Founder
Kate Tolo: Blueprint Co-Founder
Dr. Mike Mallin: Lead Physician for Bryan Johnson
Connect:
X: https://x.com/bryan_johnson
YouTube: https://www.youtube.com/@BryanJohnson
Instagram: https://www.instagram.com/bryanjohnson
TikTok: https://www.tiktok.com/@_bryan_johnson_
Chapters:
00:00 - Introduction
01:52 - First Experiences With Drugs
05:42 - Psychedelics in Society
13:29 - Psilocybin, LSD & DMT
34:35 - Marijuana
50:53 - Longevity Rankings -
Can doing lines help you live longer? That depends on what you’re taking. In this three-part series, I’m ranking drugs based on their ties to longevity, starting with ketamine and cocaine. I tested ketamine on myself to study its impacts on the brain — here’s what we found.
Study Links:
Ketamine’s Effects on Epigenetic Age
Extending Ketamine’s Therapeutic Window
Ibogaine Therapy for PTSD
Hosts:
Bryan Johnson: Blueprint Founder
Kate Tolo: Blueprint Co-Founder
Dr. Mike Mallin: Lead Physician for Bryan Johnson
Connect:
X: https://x.com/bryan_johnson
YouTube: https://www.youtube.com/@BryanJohnson
Instagram: https://www.instagram.com/bryanjohnson
TikTok: https://www.tiktok.com/@_bryan_johnson_
Chapters:
00:00 - Introduction
03:14 - Social Norms Around Drugs
08:59 - Psychedelics as Therapy: Overview
10:20 - Cocaine
17:15 - Fentanyl Dangers
23:27 - Ketamine: Brain Impacts + Longevity
41:29 - Measuring The Impacts of Psychedelics
47:51 - Longevity Rankings: Cocaine + Ketamine -
Saknas det avsnitt?
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Fitness creator Jesse James West is a natural bodybuilder who makes some of the coolest videos on YouTube for over 7 million subscribers. We’re talking about his motto of “stay relentless,” and how he balances work, health and life now that he’s newly married. Plus, he shares about the time that he also had a breakdown in Target - and how it may have saved his life.
Connect with Bryan:
X: https://x.com/bryan_johnson
YouTube: https://www.youtube.com/@BryanJohnson
Instagram: https://www.instagram.com/bryanjohnson
TikTok: https://www.tiktok.com/@_bryan_johnson_
Connect with Jesse:
YouTube: https://www.youtube.com/@JesseJamesWest
Instagram: https://www.instagram.com/jessejameswest
TikTok: https://www.tiktok.com/@jessejameswest
X: https://x.com/jessejameswestt
Chapters:
00:00:00 - Introduction
00:01:15 - Finding Work Life Balance
00:08:32 - Stay Relentless
00:11:01 - Jesse’s Darkest Moment + What He Learned
00:22:48 - What an AI Future Looks Like
00:27:24 - Jesse’s Health Protocol
00:34:26 - Longevity, Psychedelics, & Aliens
00:44:58 - Married Life + Family Planning
00:48:55 - Top Tips for Longevity
00:54:02 - Bodybuilding, Steroids, & Healthy Eating
00:57:23 - Jet Lag Protocol
00:59:32 - Living For Tomorrow = Living Forever
01:02:45 - Jesse’s Health Goals -
Between synthetic dyes, air pollution, and environmental toxins, kids have a lot of obstacles in the way of their health. I’m reviewing some top offenders (like synthetic dyes and added sugars) and discussing how to empower our kids to make informed choices.
Study Links:
Synthetic Dyes in Food & Beverages
HEPA Filters in LA Schools
US Kids Face Deadlier Odds
Peanut Allergies & Air Pollution
Hosts:
Bryan Johnson: Blueprint Founder
Kate Tolo: Blueprint Co-Founder
Dr. Mike Mallin: Lead Physician for Bryan Johnson
Connect:
X: https://x.com/bryan_johnson
YouTube: https://www.youtube.com/@BryanJohnson
Instagram: https://www.instagram.com/bryanjohnson
TikTok: https://www.tiktok.com/@_bryan_johnson_
Chapters:
00:00 - Introduction
02:20 - Synthetic Dyes + Added Sugars
14:20 - Teaching Kids About Nutrition
20:21 - Toxins, Food Allergies, & Air Quality
22:42 - Kids Health Protocol
24:24 - Screen Time, Social Media & Mental Health
26:22 - U.S. Kids Are Dying at Higher Rates
29:44 - Societal Changes for Better Health
34:41 - Empowering Kids to Make Healthy Choices -
My team and I looked into the biological effects of eating a*s and choking during sex - here’s what we found. I’m also sharing why I monitor my erections - and why this metric is critical for good health and longevity.
Study Links:
Choking During Sex
Overnight Erections
Female Erection Cycles
Hosts:
Bryan Johnson: Blueprint Founder
Kate Tolo: Blueprint Co-Founder
Dr. Mike Mallin: Lead Physician for Bryan Johnson
Connect:
X: https://x.com/bryan_johnson
YouTube: https://www.youtube.com/@BryanJohnson
Instagram: https://www.instagram.com/bryanjohnson
TikTok: https://www.tiktok.com/@_bryan_johnson_
Chapters:
00:00 - Introduction
01:15 - Taboos Around Sex
04:50 - Sex is Good For You
08:33 - Choking During Sex
15:06 - Anilingus (Rimming)
22:20 - Sexual Preferences + Microbiome
25:25 - Erection Cycles: Male and Female
34:38 - We Need More Conversations About Sex -
Had I protected my body and brain, I’d be wealthier and more successful today. Culture is lying to you — you do not need to martyr yourself to be successful. Here’s how you can avoid making the same mistake I did.
Study Links:
Burnout + Heart Attack Risk
Hours Worked + Heart Disease
Sleep Deprivation in CEOs
Sleep Deprivation in Judges
Hosts:
Bryan Johnson: Blueprint Founder
Kate Tolo: Blueprint Co-Founder
Dr. Mike Mallin: Lead Physician for Bryan Johnson
Connect:
X: https://x.com/bryan_johnson
YouTube: https://www.youtube.com/@BryanJohnson
Instagram: https://www.instagram.com/bryanjohnson
TikTok: https://www.tiktok.com/@_bryan_johnson_
Chapters:
00:00 - Introduction
03:11 - Martyring Yourself for Success
15:50 - Study: ‘Overwork Will Kill You’
20:04 - Sleep + Decision Making (Studies)
25:54 - Physical Fitness + Diet (Studies)
28:24 - Treating Health Like Religion
33:30 - Tips for Balancing Work and Health
43:58 - Resting Heart Rate Before Bed
47:06 - Protecting Your Agency -
Society is bathing us in chemicals. From wildfires to 4th of July fireworks, toxins feel inescapable. Here’s what I’m doing to limit exposure and reduce my levels.
Show Links:
Blueprint Food Guide: https://blueprint.bryanjohnson.com/pages/blueprint-protocol#food-guide
Further Listening:
“How Sauna Detoxified My Body” - Bryan Johnson Podcast
“We Need to Talk About Microplastics” - Bryan Johnson Podcast
Hosts:
Bryan Johnson: Blueprint Founder
Kate Tolo: Blueprint Co-Founder
Dr. Mike Mallin: Lead Physician for Bryan Johnson
Connect:
X: https://x.com/bryan_johnson
YouTube: https://www.youtube.com/@BryanJohnson
Instagram: https://www.instagram.com/bryanjohnson
TikTok: https://www.tiktok.com/@_bryan_johnson_
Chapters:
00:00 - Introduction
01:20 - Fireworks + Toxic Celebrations
12:27 - LA Wildfire Toxins
16:57 - Truth About Air Quality
21:23 - PFAS
31:49 - Reducing Toxins/PFAS
46:11 - Sauna, HBOT & Diet
50:13 - Don’t Freak Out -
International travel is brutal on your mind, body, and sleep. We discuss the recent data and I share my current jet lag protocol (still evolving) to help minimize the damage after long flights.
Study Links:
Olympic Athletes + Jet Lag: https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2022.998484/full
Connect:
X: https://x.com/bryan_johnson
YouTube: https://www.youtube.com/@BryanJohnson
Instagram: https://www.instagram.com/bryanjohnson
TikTok: https://www.tiktok.com/@_bryan_johnson_
Chapters:
00:00 - Introduction
01:08 - Where’s Kate?
02:00 - Bryan’s Travel Experiment
03:44 - Debunking the ‘CEO Lifestyle’
06:28 - Why Jet Lag Happens
08:00 - Jet Lag Recovery
14:00 - Improving Sleep
17:07 - Is Fighting Jet Lag Possible?
21:44 - Olympic Athlete Study
24:42 - Travel Rule of Thumb
33:55 - Shifting Your Mindset
35:10 - Setting Limits for Travel
44:25 - Jet Lag Protocol
50:41 - Stimulants During Travel
52:04 - Cryotherapy/Cold Therapy
53:00 - Episode Takeaways -
Microplastics are everywhere — even in glass bottles. Should you be worried? Kate, Mike, and I interpret the data to understand the risk. I’ll share how I reduced my own levels by 93% so you can too.
Study Links:
Glass Bottle Study: https://www.sciencedirect.com/science/article/pii/S0889157525005344
Impact on Children: https://www.nejm.org/doi/abs/10.1056/NEJMms2409092
Connect:
X: https://x.com/bryan_johnson
YouTube: https://www.youtube.com/@BryanJohnson
Instagram: https://www.instagram.com/bryanjohnson
TikTok: https://www.tiktok.com/@_bryan_johnson_
CHAPTERS
00:00 - Introduction
01:27 - No Cause for Alarm (Yet)
02:05 - Microplastics Nuance
04:04 - What Are Microplastics?
05:24 - Science Is Still Emerging
07:39 - Microplastics in Our Bodies
09:51 - Study: Microplastics in Glass Bottles
11:42 - What Can We Trust?
12:53 - Building a ‘Don’t Die’ Society
14:23 - Microplastics in IV Drips
17:11 - Impact on Kids
18:47 - Microplastics in Washing Machines
19:31 - What is ‘Don’t Die’
21:05 - Bryan’s Microplastics Measurements
22:36 - Total Plasma Exchange / Blood Donation
24:28 - The Water Bottle Dilemma
27:50 - Water Systems / Reverse Osmosis
28:36 - Reducing Microplastic Intake
32:05 - An 80/20 Approach
33:10 - Sauna and Microplastics
35:38 - A Challenge for Humanity
36:15 - Testing Microplastics at Home
37:54 - Bryan’s Upcoming Microplastics Tests
39:03 - Don’t Die Party
39:31 - Teaching Congress to Sleep -
Quality sleep is the highest-return investment I’ve ever made. In this episode we walk you through my exact protocol, so you can cherry-pick what works, experiment, and track gains for yourself.
Study Links:
https://pmc.ncbi.nlm.nih.gov/articles/PMC3902870/
Connect:
X: https://x.com/bryan_johnson
YouTube: https://www.youtube.com/@BryanJohnson
Instagram: https://www.instagram.com/bryanjohnson
TikTok: https://www.tiktok.com/@_bryan_johnson_
Chapters
00:00 – What Ruins Your Sleep Most?
01:50 – Sleep in Vegas: A Cautionary Tale
03:45 – How Important Is Sleep?
05:30 – Sleep Deprivation
07:20 – Kernel Willpower Study
09:20 – The 80/20 Of Sleep
10:10 – Being a Professional Sleeper
13:00 – Resting Heart Rate
19:00 – Psychology of Tracking Sleep
22:30 – Heart Rate (Before vs. During Sleep)
25:00 – Wearables
30:00 – Food as the #1 Sleep Killer
33:40 – 10 Rules for Perfect Sleep
44:30 – Bonus Tips
49:00 – Sleep Alone?
51:20 – Sleep + Mental Health
52:40 – Bryan’s Final Plea: Learn to Sleep -
At last, we tested sauna for longevity. I’m dropping my sauna protocol and explaining why they are definitely worth the hype. Plus, hear about my first time ever stepping into one, and why it was one of the most difficult — but rewarding — protocols I’ve ever done.
Connect:
X: https://x.com/bryan_johnson
YouTube: https://www.youtube.com/@BryanJohnson
Instagram: https://www.instagram.com/bryanjohnson
TikTok: https://www.tiktok.com/@_bryan_johnson_
Chapters
00:00 – First Impressions of Sauna
01:30 – Assessing the Sweat Response in Kate and Bryan
03:00 – Why Sauna? The Science Behind the Heat
05:20 – How Sauna Mimics Exercise
08:30 – Early Biomarker Changes with Sauna
12:00 – Protocol Design & Measurement Strategy
15:30 – Bryan’s Difficulties Starting the Sauna Protocol
18:00 – Why Bryan Ices His Testicles in the Sauna
21:00 – Electrolyte Loss & Cramping
24:30 – Dry vs. Wet Sauna
27:00 – Practical Home Sauna Protocol
30:00 – Groups Who Shouldn’t Use Sauna
33:00 – Unexpected Effects of Sauna and Areas to Explore
38:00 – Skin Exposure & Sauna Material Safety
42:30 – Sauna Hygiene & Post-Sweat Protocol
45:00 – Measuring Sweat Toxins
47:30 – Kate and Bryan’s Personal Sauna Habits
49:00 – Sun Damage and Skin Aging with Teens
54:00 – Protocol as Part of a Broader Mission -
Dr. Mike Israetel is back. We’re talking about deep work, sharing a brain with AI, strategies for creativity, and how money and fame changed our lives, for better and worse.
About Dr. Mike:
Dr. Mike Israetel is an expert in the field of fitness and performance. He’s served as a professor at Lehman College, Temple University, and the University of Central Missouri, teaching exercise science courses focusing on nutrition, strength, and hypertrophy. Learn more at: http://rpstrength.com/mike
Connect:
X: https://x.com/bryan_johnson
YouTube: https://www.youtube.com/@BryanJohnson
Instagram: https://www.instagram.com/bryanjohnson
TikTok: https://www.tiktok.com/@_bryan_johnson_
Chapters
0:00:00 - Deep Work
0:01:22 - Why Bryan Quit Flying
0:03:36 - Flow States
0:06:03 - ChatGPT & Edibles
0:08:49 - Dr. Mike’s Creative Process
0:14:36 - Everyone’s Creative Triggers
0:20:09 - Messaging Overload
0:25:28 - Fame & Money
0:34:00 - Does Money Make You Happier?
0:39:01 - Fame vs Fortune
0:50:23 - Cancel Culture
0:57:02 - Gratitude, & Identity
1:03:02 - Friendship & Fame -
I’ve become the worlds healthiest human. Today I’m sharing more on my longevity protocols and biomarker testing and why that’s an essential piece of the Don’t Die movement. We’re also getting into sperm health and why it’s important to keep your testicles cool.
Connect:
X: https://x.com/bryan_johnson
YouTube: https://www.youtube.com/@BryanJohnson
Instagram: https://www.instagram.com/bryanjohnson
TikTok: https://www.tiktok.com/@_bryan_johnson_
Chapters
0:00:00 - Today's Topics
0:04:45 - 1: The Decline of Global Sperm Health
0:08:45 - 2: Bryan’s Metrics and Above-Average Results
0:15:00 - 3: Sperm Health Reveals What?!?
0:19:20 - 4: Sauna, Ice, and Testicle Cooling
0:24:15 - 5: How to Improve Sperm Health
0:30:10 - 6: What Bryan’s Markers Actually Prove
0:35:30 - 7: A Deep Dive into Bryan’s Full Biomarker Testing
0:41:00 - 8: Oral Health, Attachment Loss, and Gum Therapy
0:47:00 - 9: What does 'Most Measured Human' mean?
0:53:30 - 10: Aging Speed, Inflammation, Testosterone
1:07:00 - 11: Where Bryan’s Protocol Needs Improvement
1:12:40 - 12: Viewer Feedback, & The Future of the Podcast -
If you’re worried about “dad bod,” listen up. We’re discussing a new study among mice. We review the new data behind dad bod and how you can prevent it. We also dive into bone health and why you should care, and the healthiest way to get your protein.
Connect:
X: https://x.com/bryan_johnson
YouTube: https://www.youtube.com/@BryanJohnson
Instagram: https://www.instagram.com/bryanjohnson
TikTok: https://www.tiktok.com/@_bryan_johnson_
Chapters
0:00 - What Is Dad Bod & Why It Matters
0:56 - Fat Cells, Testosterone & Evolution
4:44 - Culture & Aging
9:01 - Sleep, Exercise & Diet Insights
10:01 - Bone Density & Biomarkers
15:01 - Bone Health 101
18:01 - How to Rebuild Bone
23:21 - Weight-Bearing Exercise
26:00 - Nutrients That Support Bone Health
31:02 - Creatine & Calcium
35:45 - Protein Deep Dive
47:00 - Why Bryan Doesn’t Eat Meat (And Why That Triggers People) -
Is it better to work out at night or in the morning? A new WHOOP study covers new data on evening exercise. Kate, Mike and I also share why lowering your resting heart rate (RHR) may be one of the most powerful strategies for longevity and overall health.
WHOOP Study: https://www.nature.com/articles/s41467-025-58271-x
Connect:
X: https://x.com/bryan_johnson
YouTube: https://www.youtube.com/@BryanJohnson
Instagram: https://www.instagram.com/bryanjohnson
TikTok: https://www.tiktok.com/@_bryan_johnson_
Chapters
0:00 - Intro
0:58 - New Whoop Study
13:30 - Exercise vs Sleep
16:04 - Is Resting Heart Rate The Most Important Biomarker?
28:50 - How To Lower Resting Heart Rate?
40:36 - Building A Wind-Down Routine
45:44 - What’s A Good Resting Heart Rate? -
There’s a new treatment for longevity — one you probably haven’t heard of before. I review my experiments with hyperbaric oxygen therapy (HBOT) and how it dramatically transformed my biomarkers. We’ll also cover the ways air pollution shows up in your body, something I experienced firsthand while traveling in India.
Links and Studies
Analyzing India’s Air Quality: https://x.com/bryan_johnson/status/1863474991142236217
https://x.com/bryan_johnson/status/1864091348179222955
Bryan’s HBOT protocol + results:
https://x.com/bryan_johnson/status/1861085751024484459
https://x.com/bryan_johnson/status/1902044120807567436
Connect:
X: https://x.com/bryan_johnson
YouTube: https://www.youtube.com/@BryanJohnson
Instagram: https://www.instagram.com/bryanjohnson
TikTok: https://www.tiktok.com/@_bryan_johnson_
Chapters
0:00 - Intro
1:02 - Hyperbaric Oxygen Therapy (Bryan's Results)
15:37 - India's Air Pollution
23:58 - Air Quality Protocol
29:49 - Have A Plan -
What’s the truth when it comes to creatine? And which sleep tracker gets you the best results? Blueprint co-founder Kate Tolo and Blueprint Chief Medical Officer Dr. Mike Mallin join me to discuss the science behind some of the hottest wellness topics to find out which ones are actually worth your time.
UNSW Creatine study: https://www.unsw.edu.au/newsroom/news/2025/03/sports-supplement-creatine-makes-no-difference-to-muscle-gains-trial-finds
Andrej Karpathy’s sleep tracker study: https://karpathy.bearblog.dev/finding-the-best-sleep-tracker/
Connect:
X: https://x.com/bryan_johnson
YouTube: https://www.youtube.com/@BryanJohnson
Instagram: https://www.instagram.com/bryanjohnson
TikTok: https://www.tiktok.com/@_bryan_johnson_
Chapters
0:00 - Intro
0:41 - 1: Welcome to the Don't Die podcast
2:52 - 2: Dr. Mike’s experience as an ER physician
7:32 - 3: Difference between America and New Zealand ER
9:38 - 4: Dr. Mike on using ChatGPT
13:00 - 5: New study on creatine effectiveness
18:40 - 6: How much creatine to take per day
24:33 - 7: Body awareness
29:33 - 8: Blueprint protocol’s limit in slowing aging
30:57 - 9: Andrej Karpathy’s sleep monitor study
36:10 - Conclusion
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The Bryan Johnson Podcast is ushering in a new era of being human. In this podcast I am joined by longevity physician Dr. Mike Mallin, my co-founder Kate Tolo, and the occasional guest. We discuss the science-based protocol to help you become your best self. Join us on this journey. New episodes releasing weekly.
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Fitness expert Dr. Mike Israetel shares his take on artificial intelligence, what to consider before trying steroids, and his experience dealing with haters. Dr. Mike Israetel is an expert in the field of fitness and performance. He’s served as a professor at Lehman College, Temple University, and the University of Central Missouri, teaching exercise science courses focusing on nutrition, strength, and hypertrophy.
Learn more about Dr. Mike: http://rpstrength.com/mike
Connect:
X: https://x.com/bryan_johnson
YouTube: https://www.youtube.com/@BryanJohnson
Instagram: https://www.instagram.com/bryanjohnson
TikTok: https://www.tiktok.com/@_bryan_johnson_
Chapters
0:00 - Intro
0:58 - 1: How Mike deals with online fame
8:38 - 2: The future of fitness
18:24 - 3: Why Mike started bodybuilding
21:33 - 4: Mike and his wife’s love story
23:42 - 5: Steroids & side-effects
31:33 - 6: Advice to young people who want to try steroids
40:18 - 7: How “Don’t Die” works
49:38 - 8: AI is getting smarter than us
56:49 - 9: How to plan for the future
59:56 - 10: Mike’s 'biological age' results
1:09:51 - 11: Feedback from Mike
1:18:30 - 12: First meeting
1:25:39 - 13: Should we arm wrestle?
1:36:16 - 14: How Bryan handled his depression
1:40:39 - Conclusion -
Just how bad is Trevor Wallace’s comedy career for his body? Comedian and host of the podcast “Stiff Socks” talks about his life on the road. I offer Trevor some practical tips to help him look and feel his best.
Connect:
X: https://x.com/bryan_johnson
YouTube: https://www.youtube.com/@BryanJohnson
Instagram: https://www.instagram.com/bryanjohnson
TikTok: https://www.tiktok.com/@_bryan_johnson_'
Chapters
0:00 - Intro
1:01 - 1: Trevor's Leftover Pasta Breakfasts
4:34 - 2: The Convenience Trap
7:23 - 3: My Practical Health Advice
10:45 - 4: Sleep, Stimulants & Recovery Protocols
14:24 - 5: How to Build a Wind-Down Ritual
19:56 - 6: Plasma Transfusions & Family Experiments
21:00 - 7: Trevor’s 'Biological Age' Test Results
