Avsnitt
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In this episode we discuss:Why insulin resistance and diabetes are not caused by excess carbohydrate consumption and are not actually an insulin signaling problem The problems with the idea of metabolic flexibility, earning your carbs, and the carb-insulin model of obesity Why carbs are beneficial even for people who have insulin resistance or diabetes The role of fat burning and stress in driving insulin resistance Specific diet, movement, and supplement recommendations to reverse insulin resistance and diabetes
Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/
Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/
Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-110-the-true-cause-of-insulin-resistance-and-diabetes-from-the-bioenergetic-view/
Timestamps:
0:00 – intro
1:14 – metabolic flexibility, earning your carbs, the carb-insulin model of obesity, and dispelling other common insulin resistance myths
7:48 – low-carb, keto, and carnivore diets may improve symptoms but are not the solution for insulin resistance
13:13 – what the mainstream views of insulin resistance gets wrong when it comes to what causes insulin resistance
15:50 – why you might not want to use a continuous glucose monitor and the unnecessary fear of blood glucose spikes
17:48 – whether insulin is harmful and whether we want to keep insulin levels as low as possible
22:15 – whether we can restore optimal insulin sensitivity without low-carb diets
25:16 –the bioenergetic view of insulin resistance
27:12 – insulin resistance as an adaptive evolutionary process that is crucial for survival
31:22 – the difference between physiological and pathological insulin resistance
34:40 – how inhibited glucose oxidation causes insulin resistance
40:46 – how fatty acid oxidation causes increased production of ROS, slows cellular respiration, and blocks glucose oxidation (The Randle Cycle)
51:06 – the harms of ROS production from fatty acid oxidation and other forms of stress
53:04 – insulin resistance as an energy deficient state
54:19 – insulin resistance is not an insulin signaling problem, it’s an energy production problem
58:30 – the role of stress hormones (like cortisol) in insulin resistance
1:02:09 – how insulin and carbohydrates decrease stress
1:05:59 – how to fix insulin resistance and restore insulin sensitivity by fixing our capacity to produce energy
1:10:38 – specific diet, movement, and supplementation recommendations for insulin resistance and diabetes
1:17:55 – why you don’t need to tailor your carb intake to your carb tolerance
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In this episode we discuss:Our thoughts on Chris Palmer’s “Brain Energy” theory of mental healthWhy low carb diets are not the solution for anxiety and depression and what to do instead What most people miss when it comes to weight loss and why we shouldn’t focus on fat-burning Strategies to optimally manage blood sugar for Type 1 DiabetesWhether we should lower our fat intake to lose weight
Sign up for the Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide
Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/
Click here to check out the show notes: https:/jayfeldmanwellness.com/ep-109-chris-palmers-brain-energy-type-1-diabetes-and-low-fat-diets-for-weight-loss-qa
Timestamps:
0:00 – intro
1:19 – our take on Chris Palmer's “Brain Energy” theory of mental health disorders
5:04 – challenging the misconception of a separation between the brain and body
8:03 – why low-carb, ketogenic, and carnivore diets can produce temporary mental health benefits
10:36 – how impaired energy production underlies poor brain health and how to fix it without using low-carb diets
14:05 – how fat burning can temporarily relieve symptoms of poor glucose utilization (with a major cost)
18:29 – why fatty acid oxidation is our default metabolic state under stress and underlies all chronic disease
22:20 – whether ketogenic diets promote metabolic flexibility
24:53 – poor glucose metabolism as a driver of Alzheimer’s disease and other mental health conditions
28:13 – the adaptive benefit of burning fat during stress
31:31 – blood sugar management for Type 1 Diabetes and whether a low-carb diet is optimal
38:13 – whether lowering fat intake is necessary for burning and losing fat
42:09 – whether improving metabolic function alone is enough to reduce stored fat and when a decrease in dietary fat intake may be necessary
47:32 – the difference between subcutaneous fat and visceral fat and their potential implications
50:34 – how to fix our hunger signals to prevent excessive eating
54:33 – weighing the costs of extreme diets and the need for more innovative thinking around health
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Saknas det avsnitt?
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In this episode we discuss:The unexpected costs of using excess exercise to lose weight Our thoughts on Herman Pontzer’s book Burn and the Constrained Model of Energy Expenditure Our thoughts on Ted Naiman’s protein to energy ratio diet (PE Diet) The cost of eating too much protein and what to do instead How to increase caloric intake to raise your metabolism and reverse hypothyroidism The major category of nutrients that’s often missed for optimizing mitochondrial function
Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy
Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/
Click here to check out the show notes: https:/jayfeldmanwellness.com/ep-108-herman-pontzers-burn-ted-naimans-pe-diet-and-increasing-calorie-intake-to-raise-metabolism-qa/
Timestamps:
1:25 – Herman Pontzer’s Constrained Model of Energy Expenditure and the adverse effects of energy deficits
7:13 – problems with the additive model of energy expenditure and the physiological cost of excess exercise
10:40 – environmental factors that we can change to increase metabolism
16:42 – the unexpected costs of using excessive exercise to lose weight
19:16 – weight gain as an adaptive response to an energy deficit
22:46 – when eating too much can be a problem and how to identify your ideal calorie intake
32:18 – Ted Naiman’s protein to energy ratio diet and optimal protein intake
41:13 – the problems with using protein as an energy source
46:45 – how to increase caloric intake to raise metabolism and reverse hypothyroidism
50:47 – how to track your symptoms and progress to better guide your nutrient goals
56:55 – the best foods for increasing calorie intake and what to do if you have a low appetite
1:00:30 – the essential role of both macro and micronutrient density in promoting mitochondrial health
1:04:00 – why sugar cravings are not the same as sugar addiction
1:06:46 – easy ways to incorporate more macro and micro nutrient dense foods into your diet
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In this episode we discuss:Studies showing that omega-3 consumption decreases lifespan and increases disease processes The potentially harmful effects of omega-3 usage during pregnancy on offspring The impact of omega-3s on inflammation, endotoxin, and mitochondrial respiration The data in native cultures showing that omega-3 intake doesn’t improve cardiovascular disease or mortality Extremely healthy populations that consume high-carb and high-saturated fat diets with almost no omega-3s
Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/
Download the Free Energy Balance Food Guide here: https://www.jayfeldmanwellness.com/guide/
Click here to check out the show notes: https:/jayfeldmanwellness.com/ep-107-omega-3s-decrease-lifespan-and-increase-disease
Timestamps:
0:00 – intro
1:30 – studies showing that omega-3 consumption decreases lifespan and increases disease processes in animals
13:55 – studies on animals showing the harmful effects of omega-3 consumption during pregnancy on offspring
17:37 – studies showing that omega-3 consumption contributes to disease processes, increases inflammation, causes oxidative stress, increases endotoxin, and interferes with mitochondrial respiration
28:19 – whether we should be concerned about saturated fats increasing endotoxin absorption
29:33 – how omega-3 consumption leaves us more susceptible to damage when we’re under stress
32:53 – whether we should be consuming fatty fish
35:01 – the lack of benefit of omega-3 consumption in native populations consuming large amounts of fatty fish and seafood
38:40 – low incidence of cardiovascular disease in native populations consuming very little omega-3s
59:30 – concluding thoughts on whether we should consume omega-3s based on the data on omega-3s in RBCs and phospholipids and mortality
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In this episode we discuss:Studies showing that fish oil and cod liver oil supplementation increase oxidative damage in humans, even in the triglyceride form alongside antioxidants Why omega-3s are harmful in both healthy and unhealthy humans The harmful metabolic and hormetic effects of omega-3s (and why omega-3s aren’t beneficial due to hormesis) The research showing that omega-3s do not improve chronic health conditions or mortality in humans
Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy
Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/
Click here to check out the show notes: https:/jayfeldmanwellness.com/ep-106-omega-3s-increase-inflammation-and-oxidative-stress/
Timestamps:
0:00 – intro
1:26 – a summary of the harmful effects of omega-3 consumption in humans
9:14 – omega-3 consumption amplifies the damage from stress (including fasting)
17:08 – vitamin E does not protect against lipid peroxidation from fish oil consumption
20:06 – studies showing that increased omega-3 consumption (including fish oil and cod liver oil) in humans and other animals increases lipid peroxidation, even in triglyceride form
31:45 - how omega-3s triggers hormesis, and why this doesn’t make omega-3s beneficial
39:50 – the context of the omega-3 research and its application
42:57 – studies showing that omega-3 supplementation doesn’t improve chronic health conditions or reduce mortality in humans
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In this episode we discuss:Whether the research suggesting that omega-3s decrease mortality is validOmega-6 intake as a major confounding variable when looking at omega-3 researchThe dramatic lifespan-lowering effect of omega-3s and total PUFA across all speciesHow omega-3s increase susceptibility to oxidative stress and damageLooking at the Masai diet as an example of a low-omega-3 diet with high omega-3s in the red blood cells
Download the Free Energy Balance Food Guide here: https://www.jayfeldmanwellness.com/guide/
Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/
Click here to check out the show notes:
https://jayfeldmanwellness.com/ep-105-challenging-the-idea-that-increased-omega-3-consumption-lowers-mortality/
Timestamps:
0:00 – intro
1:35 – why we’re discussing omega-3s and lifespan
8:10 – the studies showing an association between omega-3 content in phospholipid and reduced mortality
16:48 – conflict of interest as a confounding variable in these studies
18:12 – healthy user bias as a confounding variable in these studies
20:46 – omega-6 consumption as a confounding variable in these studies
29:04 – problems with using RBC phospholipids and serum fatty acids as markers of fatty acid composition of the diet
30:35 – a low omega-6 diet will increase omega-3 content in the RBC phospholipids and serum fatty acids
36:35 – the effect of heritability on RBC phospholipid and serum fatty acid composition
43:58 – the effect of oxidative stress on RBC phospholipid and serum fatty acid composition
52:57 – why it’s important to consider interventional studies and other research to determine whether we should increase omega-3 consumption to reduce mortality
55:30 – research looking at the relationship between composition of phospholipids and lifespan across species
1:07:33 – research looking at the relationship between composition of phospholipids and lifespan within species
1:23:30 – increased consumption of omega-3s increases omega-3 content in phospholipids and therefore the peroxidizability index
1:28:53 – looking at the Masai diet: low omega-6 intake increases omega-3 content in RBC fatty acids
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In this episode we discuss:Individualism and competition vs. collaboration and communitarianismWhether humans are inherently selfish and destructive The cost of social media and other forms of distractionHow drugs and alcohol can function as numbing agents Why many causes that appear worthy turn out to be distractions from the real problems
Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/
Download the Free Energy Balance Food Guide here: https://www.jayfeldmanwellness.com/guide/
Click here to check out the show notes:
https://jayfeldmanwellness.com/ep-104-how-western-culture-keeps-us-distracted-and-fighting-amongst-ourselves/
Timestamps:
1:14 – individualism and competition vs. collaboration and communitarianism
25:45 – randomness, subjectivism, moral relativism, and the resulting nihilism
31:20 – the consequences of the idea that humans are selfish, destructive, and useless other than what we can produce
41:39 – how potentially beneficial advancements become co-opted to maintain the current power structure
48:04 – how western culture degrades esteem and prevents self-actualization
49:43 – the many aspects of modern technology and entertainment that distract us from what’s important
55:26 – how drugs and alcohol can also function as numbing agents
1:03:42 – how worthy causes become co-opted to prevent legitimate progress
1:13:18 – contrasting with cultures that are family-oriented and less distracted by technology
1:16:10 – the effects of culture in science, health, and everyday life
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In this episode we discuss:How lower wages and higher costs have dramatically reduced our quality of lifeHow we’ve ended up working more and resting less with worse outcomesWhether advancements in technology have improved the quality of life of the average personHow marketing and consumerism keep us on the hamster wheelThe hidden costs of convenience cultureConcerns surrounding the collusion between government and corporationsHow divide and conquer tactics convince us to blame each other rather than the powers that oppress us
Download the Free Energy Balance Food Guide here: https://www.jayfeldmanwellness.com/guide/
Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy
Click here to check out the show notes:
https://jayfeldmanwellness.com/ep-103-how-western-culture-keeps-us-poor-and-destroys-our-family-community-and-relationships/
Timestamps:
1:34 – how western culture degrades safety and security through financial means
7:33 – how lower wages with higher costs reduces safety and forces people to prioritize work over quality of life
15:14 – we currently work more with less leisure time than ever before, with worse outcomes
20:24 – the cost of consumer culture and marketing as an engine that drives consumerism
30:53 – the cost of convenience culture: freedom, privacy, morals, ethics, and health
36:14 – the problems with profit-driven motives and the collusion between government and corporations
45:36 – how western society has become fragile and unstable
51:13 – how western culture degrades relationships and feelings of love and belonging
52:41 – continued how western culture degrades relationships and feelings of love and belonging
53:27 – divide and conquer tactics within western culture and encouraging the “us vs. them” mentality
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In this episode we discuss:Why culture matters and how we can effectively navigate itThe impact of the diet culture and the “eat less exercise more” paradigmHow Western culture blames the individual for their poor health and the toll that this takes The problems with excess work, time indoors, and sedentarismHow the modern medical system takes away your capacity to improve your healthWhy the alternative health sphere can be just as problematic as mainstream medicine
Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy
Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/
Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-102-how-western-culture-mainstream-medicine-keep-us-sick/
Timestamps:
0:00 – why we’re discussing culture and our concerns with the culture in the US and the relationship between culture and health
6:05 – frames through which we can view culture and the importance of Maslow’s hierarchy of needs
13:00 – how western culture degrades health: diet culture and the food industry
27:43 – how western culture degrades health: excess work, time indoors, and sedentarism
34:30 – how easily we can become numb to the effects of our culture or environment
38:07 – the broken modern medical system and the problems with the allopathic, symptom management model
48:21 – problems with the alternative health sphere
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In this episode we discuss:Why you want to avoid vegetarian-fed chicken and acorn-fed pork The best bioenergetic fat, protein, and carb sources Why it’s best to avoid salmon and bluefin tuna, and what fish and seafood to have instead Whether we should be including vegetables and fiber in our diet How to avoid vegetable oils and what fats to use instead When it makes sense to include high-FODMAP foods
Download the Free Energy Balance Food Guide here: https://www.jayfeldmanwellness.com/guide/
Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/
Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy
Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-101-building-a-bioenergetic-diet-optimal-carb-fat-and-protein-sources/
Timestamps:
0:00 – intro
1:34 - bioenergetic food guide
2:59 - bioenergetic fat sources
6:20 - bioenergetic protein sources
15:01 - the importance of collagen/gelatin
18:51 - bioenergetic carbohydrate sources
31:25 – foods and additives to avoid
34:15 – experimentation and context as primary components of the bioenergetic view
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In this episode we discuss:Optimal macronutrient breakdowns for meals and snacksHow to calculate your protein, carbohydrate, and fat needsHow to use taste, cravings, hunger, and experimentation to guide your macro intakeHow to find your starting calorie intakeThe optimal number of meals and snacks to have in a day
Download the Free Energy Balance Food Guide here: https://www.jayfeldmanwellness.com/guide/
Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/
Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-100-building-a-bioenergetic-diet-macros-calories-and-meal-timing/
Timestamps:
0:00 – intro
1:21 – context for these dietary guidelines and the importance of the “why”
7:58 – guidelines for optimal protein intake from the bioenergetic view
14:46 – guidelines for optimal fat intake from the bioenergetic view
29:27 – guidelines for optimal carb intake from the bioenergetic view
31:32 – how to find your starting calorie intake
35:29 – guidelines for optimal carb intake from the bioenergetic view (continued)
42:00 – using taste, cravings, hunger, and experimentation to adjust these guidelines
45:35 – guidelines for optimal meal and snack timing and composition from the bioenergetic view
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In this episode we discuss:The problems with using T4-only medications like Synthroid and levothyroxine for hypothyroidism When it makes sense to use thyroid hormone supplements How to use T3, T4, and/or desiccated thyroid (NDT) for hypothyroidism Whether thyroid hormones should be taken away from food due to absorption concerns Whether we should be concerned about thyroid hormone supplementation suppressing our own thyroid hormone production
Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy
Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/
Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-99-medications-supplements-for-hypothyroidism-and-the-problems-with-t4-medications-hypothyroidism-part-5/
Timestamps:
0:00 – intro
1:24 – vitamin and mineral supplementation for thyroid function
5:22 – the context for using thyroid hormone supplementation
7:16 – the problems with using T4-only medications (like Synthroid and levothyroxine) for hypothyroidism
13:58 – evidence that T4 monotherapy is less effective than T3/T4 combination therapy
21:48 – how to use T3, T4, and/or desiccated thyroid (NDT) for hypothyroidism
37:15 – whether thyroid hormones should be taken away from food due to absorption concerns
41:49 – how much is 1 grain of desiccated thyroid?
42:29 – whether thyroid hormone supplements are pharmaceuticals, food, or something in between
44:30 – whether we should be concerned about thyroid hormone supplementation suppressing endogenous thyroid hormone production
46:50 – thyroid hormone supplements in context
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In this episode we discuss:How fasting decreases thyroid function Why carbs are essential for thyroid function Specific anti-thyroid foods to avoid Why interventions like cold thermogenesis, caloric restriction, and fasting are not the answer for hypothyroidism The impact of sleep on our thyroid health
Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy
Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/
Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-98-how-to-optimize-your-diet-lifestyle-for-hypothyroidism-hypothyroidism-part-4
Timestamps:
0:00 – intro
1:06 – how to address and reverse hypothyroidism
2:36 – the importance of carbs, calories, and fat for improving thyroid function
16:24 – the importance of eating consistently (and not fasting) for thyroid function
18:00 – saturated fats vs. PUFA and micronutrients for thyroid function
19:45 – basic bioenergetic diet recommendations for hypothyroidism
22:14 – anti-thyroid foods (goitrogens) to avoid
23:08 – other diet considerations when transitioning to a bioenergetic approach
25:56 – low iron in women and excess iron from carnivore or keto diets
27:47 – cruciferous vegetables and thyroid health
28:43 – how to properly address nutrient deficiencies for thyroid health
35:06 – whether stressors like exercise, cold thermogenesis, caloric restriction, and fasting are supportive of thyroid health
47:54 – optimizing sleep for thyroid function
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In this episode we discuss:What causes Hashimoto’s hypothyroidism How to properly interpret your thyroid bloodwork (and what your doctor likely doesn’t know about thyroid testing)How your cholesterol values can be used as markers of thyroid status How symptoms like metabolic rate, body temperature, and pulse rate can be more helpful than blood tests when identifying thyroid status Ideal blood test values for optimal thyroid function
Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/
Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy
Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-97-how-to-properly-test-for-thyroid-function-hypothyroidism-part-3
Timestamps:
0:00 – intro
1:17 – what causes Hashimoto’s hypothyroidism and autoimmunity in general
13:30 – how to interpret thyroid blood tests (TSH, T3, T4, rT3)
31:34 – what reverse T3 means on a blood test and how to interpret rT3 values
34:44 – looking at all thyroid markers together to determine thyroid status
37:05 – the anti-thyroid effects of reverse T3
40:38 – cholesterol levels as a marker of thyroid status, and the problems with cholesterol levels that are too high or too low
52:34 – the relationship between cholesterol, heart disease, and thyroid status
56:04 – other blood markers that can be indicative of thyroid status (SHBG, ferritin)
57:02 – how we can use symptoms like metabolic rate, body temperature, and pulse rate to determine thyroid status
1:12:14 – other symptoms that can be used as indicators of thyroid status (low energy, fatigue, low immune function, dry or cracking skin, hair loss brittle nails, slow motility, weight gain, low mood)
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In this episode we discuss:
The factors that affect thyroid hormone production, conversion, transport, and uptake
How high TSH levels cause damage to the thyroid gland
High-carb diets vs. low-carb diets for thyroid health
Why restricting calories is not the way to go if you’re struggling with hypothyroidism
The effects of PUFA and endotoxin on thyroid hormone activity
The problems with both deficiencies and excesses of iron, iodine, and vitamin A for thyroid health
Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy
Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-96-avoid-low-carb-diets-fasting-and-caloric-restriction-if-you-have-hypothyroidism-hypothyroidism-part-2/
Timestamps:
0:00 – intro
1:28 – the factors that affect thyroid hormone production, conversion, transport, and uptake
3:45 – the impact of stress on thyroid hormone production and conversion
5:02 – how the stress hormones and inflammatory cytokines affect thyroid hormone production and conversion
16:44 – thyroid hormones increase sensitivity to stress hormones
21:44 – elevated free fatty acids, especially PUFA, inhibit thyroid hormone binding
23:26 – how a lack of energy prevents the cells from taking up thyroid hormone
30:00 – how oxidative stress affects thyroid hormone production and the effects of TSH on oxidative stress
38:25 – how a low-carb diet affects thyroid hormone production and conversion, causing a hypothyroid state; high-carb diets vs. low-carb diets for thyroid health
47:46 – insulin resistance is associated with reduced thyroid hormone conversion, but this doesn’t mean you should avoid carbohydrates
51:39 – how caloric restriction affects thyroid status
55:04 – the effects of fasting on thyroid status
56:42 – T3 has positive feedback on its own production and what this means for thyroid hormone replacement
1:00:01 – the effects of PUFA and endotoxin on thyroid hormone activity
1:04:30 – the effects of micronutrients, specifically iron, vitamin A, selenium, and iodine, on thyroid hormone production, conversion, and activity
1:16:30 – increased thyroid activity increases macronutrient and micronutrient needs, but also improves micronutrient retention in the long-term
1:19:15 – the effects of environmental toxins (pesticides, industrial chemicals, heavy metals, etc.) on thyroid hormone production, conversion, and activity
1:25:20 – the effect of sleep on thyroid hormone production and conversion
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In this episode we discuss:
Why hypothyroidism is not the root cause of your issues
Why TSH on its own is not a good marker of thyroid status
The importance of thyroid hormones for sex hormone production, gut health, and immune function
T3’s effects on autophagy, mitochondrial biogenesis, and uncoupling
Whether low thyroid activity is beneficial for longevity and aging and when a high TSH may be a good sign
Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy
Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-95-hypothyroidism-in-context-thyroid-hormone-basics-hypothyroidism-part-1/
Timestamps:
0:00 – intro
1:19 – an introduction to hypothyroidism and common symptoms of hypothyroidism
9:02 – the broader biological context of hypothyroidism and hypothyroidism as a low metabolic state
12:45 – why hypothyroidism is not the root cause
16:23 – the basics of the different thyroid hormones and their regulation
19:54 – the hypothalamic-pituitary-thyroid axis and the nuances within the negative feedback loops
24:45 – the basics of thyroid hormone production
29:37 – the basics of thyroid hormone conversion
35:17 – the larger context of thyroid hormone production and conversion
38:58 – the basics of thyroid hormone transport
41:44 – the basics of thyroid hormone uptake
46:23 – the nutrients involved in thyroid hormone production and conversion
50:26 – the cellular effects of T3 (metabolic stimulation, uncoupling, autophagy, mitochondrial biogenesis, steroidogenesis from cholesterol)
57:29 – the effects of T3 on gut health, immune function, and aging
1:03:08 – whether low thyroid activity is beneficial for longevity and aging and when a high TSH may be a good sign
1:08:41 – the relationship between vitamin A and thyroid hormones
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In this episode we discuss:
Why uncoupling is harmful in certain contexts and how PUFA cause constant, low-level uncoupling
The involvement of uncoupling, mitochondrial biogenesis, autophagy, heat shock proteins, and hypoxia-inducible factors in the stress response
How stress prevents our mitochondria from effectively producing energy
How chronic stress causes insulin resistance, high blood pressure, weight gain, depression, and cardiovascular disease
How sugar and fat cravings result from stress and why listening to them is beneficial
How adaptations to stress get passed on through generations
Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy
Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-94-how-stress-crashes-your-metabolism-why-hormesis-is-not-the-answer-stress-mitochondria-part-2/
Timestamps:
0:00 – intro
2:59 – the details of how mitochondrial respiration can become disrupted, especially from glucocorticoids
6:05 – the short-term effects of catecholamines
8:34 – why uncoupling is harmful in certain contexts and how PUFA cause constant, low-level uncoupling
14:40 – the protective effects of uncoupling as a part of the stress response
20:08 – the role of cytokines (TNF-alpha, IL-1, IL-6, heat-shock proteins, NF-kB, HIF) in the stress response
37:33 – the effect of acute stress on energy production in mitochondria
45:18– the effect of chronic stress on energy production in mitochondria
48:15 – how stress drives degeneration and the evidence for increased activity of hormetic pathways (including effects like mitochondrial biogenesis and autophagy) in degenerative states
1:05:24 – the relationship between mental health, mood, and metabolic function
1:10:21 – how adaptations to stress get passed on through mitochondrial DNA
1:18:32 – how to best improve mitochondrial function and our health
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In this episode we discuss:
Why stress is not your friend
The effects of cortisol on your mitochondria
Hans Selye’s general adaptation syndrome
How cortisol causes mitochondrial dysfunction, heart disease, insulin resistance, autoimmunity, allergies & hypersensitivity, mineral imbalances, and cancer metabolism
Why acute stress does not lead to improved health via hormesis
Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy
Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-93-how-cortisol-affects-your-mitochondria-acute-vs-chronic-stress-stress-mitochondria-part-1-ep-93/
Timestamps:
3:00 – an introduction to the paper: mitochondria as key components of the stress response
4:03 – Hans Selye’s general adaptation syndrome and the process of stress in relation to energy balance
23:30 – the 3 main effects of the stress hormones in the acute stress response and the cost to this response
31:48 – long-term glucocorticoid exposure causes insulin resistance and the protective effects of high blood sugar in certain contexts
34:04 – how long-term stress causes degeneration
34:55 – functions of the mitochondria
38:54 – mitochondria upregulate energy production in response to stress
41:06 – the short-term vs. long-term effects of the glucocorticoids (cortisol)
44:03 – how stress causes hormetic adaptations and how the hormetic pathways cause degeneration over time
50:30 – how mitochondria respond to excess stress and how this relates to fat gain
59:04 – how chronic stress and exposure to cortisol causes impaired energy production, degeneration, immunosuppression & autoimmunity, mineral imbalance, swelling, allergies & hypersensitivity, and cancer metabolism
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Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-92-celebrating-ray-peat/
Ray Peat's Website: http://raypeat.com/
Ray Peat Interviews, Articles, Related Websites, and Other Resources: https://www.selftestable.com/ray-peat-stuff/sites
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In this episode we discuss:
Whether cod liver oil is an ideal source of vitamin A/retinol
Whether we should be concerned about the omega-3 content of cod liver oil (CLO)
The idea that we want our fat cells to be insulin resistant to lose fat
Whether keeping insulin low is the key to fat loss
What hormones regulate fat loss
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Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-91-cod-liver-oil-dangers-the-croissant-diet-and-insulin-resistant-fat-cells-q-a/
Timestamps:
2:54 – what we think about cod liver oil as a vitamin A source
9:50 – why someone may benefit from cod liver oil, and why it likely isn’t a result of the retinol
10:56 – the immunosuppressive effects of omega-3s
14:25 – the major problems with omega-3s, including cod liver oil specifically
25:33 – clarifying our thoughts on the Croissant Diet
28:26 – burning saturated fat versus burning PUFA and whether PUFA create more ROS than saturated fats
31:41 – what we think of the idea that consuming saturated fats will allow for fat loss by causing insulin resistance in the adipocytes (fat cells)
42:50 – why increasing fat burning doesn’t inherently lead to increased fat loss
47:11 – whether increasing satiety is the key to fat loss
- Visa fler