Avsnitt
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Pharmacotherapy in the Critically Ill Pregnant Patient: Part II
Special Guests: Allison Lankford, MD
Melissa Thompson Bastin, PharmD, PhD, BCCCP, FCCM, FCCP @mtbastin
04:50 – Obstetric hemorrhage
18:20 – Ectopic pregnancy
22:30 – Hypertensive emergency
28:45 – Pre-eclampsia/eclampsia
35:00 – Lactation considerations
39:35 – Take-home points
Pharmacotherapy “Caring for two in the ICU” articles:
Part I: https://pubmed.ncbi.nlm.nih.gov/36938691/
Part II: https://pubmed.ncbi.nlm.nih.gov/37323102/
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2024 Critical Care Trials March Madness Bracket Preview: Part II
Cardiac/Pulmonary and Sepsis/Fluids Regions
CV/Pulm Bracketologist: Jolie Gallagher, PharmD, BCCCP
Sepsis/Fluids Bracketologist: Clay Small, PharmD, BCCCP
PubMed links for all 68 Critical Care March Madness trials: https://pharmacytodose.files.wordpress.com/2024/03/critical-care-trials-reference-list-all-regions.pdf
2024 March Madness Bracket: https://pharmacytodose.com/2024/03/17/2024-critical-care-trials-march-madness-bracket/
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Saknas det avsnitt?
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2024 Critical Care Trials March Madness Bracket Preview: Part I
Bleeding/Blood Glucose and Neuro/PADIS Regions
Bleeding/BG Bracketologist: Jason Hecht, PharmD, BCPS, BCCCP, FCCM
Neuro/PADIS Bracketologist: Karen Berger, PharmD, FASHP, FCCM, BCPS, BCCCP @karenccrx
PubMed links for all 68 Critical Care March Madness trials: https://pharmacytodose.files.wordpress.com/2024/03/critical-care-trials-reference-list-all-regions.pdf
2024 March Madness Bracket: https://pharmacytodose.com/2024/03/17/2024-critical-care-trials-march-madness-bracket/
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Trial of the Week: CHAMPION PHOENIX
Special Guest: Jack Pluenneke, PharmD, BCCP @JackPluenneke
Jack Pluenneke joins to discuss a March 2024 Trial of the Week, “Effect of platelet inhibition with cangrelor during PCI on ischemic events” the CHAMPION PHOENIX trial, published in 2013 in NEJM.
We review PK/PD advantages with cangrelor, go over the CHAMPION trials, and then highlight why the CHAMPION PHOENIX trial was necessary. Then we dive into the Trial of the Week: CHAMPION PHOENIX trial and discuss its findings as well as study design. Are these patients we’d see in our ICU? How does cangrelor compare to glycoprotein 2b/3a inhibitors? Is it a weakness that the comparator group uses clopidogrel? The episode closes with medication safety considerations, cangrelor’s place in therapy, and much more.
Reference list: https://pharmacytodose.files.wordpress.com/2024/03/champion-phoenix-trial-of-the-week-references-1.pdf
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Corticosteroids in the Critically Ill
Special Guest: Andrea Nei, PharmD, BCPS, BCCCP, FCCM @Dre_pharmd
04:40 – Guideline introduction/background
08:35 – Scope/authorship
13:35 – PICO questions/recommendations
14:22 – Sepsis
17:20 – CAP
19:10 – ARDS
21:55 – Research priorities/Take-home points
28:50 – Working with your spouse
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Trial of the Week: REDUCE
Special Guest: Matt Duprey, PharmD, PhD, BCCCP
Matt Duprey joins to discuss the March Trial of the Week, published in 2018 in JAMA: “The Effect of Haloperidol on Survival Among Critically Ill Adults with a High Risk of Delirium: the REDUCE Randomized Clinical Trial.”
We review the history of antipsychotic pharmacotherapy treatment and prophylaxis in delirium, reviewing guideline recommendations from that time. Then we dive into the Trial of the Week: REDUCE trial and discuss its findings as well as study design. Would results be the same with another medication? Why is delirium research so challenging? Prevalent v. incident delirium? What’s the best outcome to measure? What questions still need answered? These questions and so much more are answered in today's episode.
Reference list: https://pharmacytodose.files.wordpress.com/2024/03/reduce-references.pdf
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Pharmacotherapy in the Critically Ill Pregnant Patient: Part I
Special Guests: Allison Lankford, MD
Melissa Thompson Bastin, PharmD, PhD, BCCCP, FCCM, FCCP @mtbastin
08:05 – PK/PD changes
12:50 – Medication safety/Drug information resources
20:15 – Maternal sepsis
33:15 – ARDS
43:15 – PADIS
48:45 – Cardiogenic shock & cardiac arrest
59:00 – VTE
Pharmacotherapy “Caring for two in the ICU” articles:
Part I: https://pubmed.ncbi.nlm.nih.gov/36938691/
Part II: https://pubmed.ncbi.nlm.nih.gov/37323102/
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Trial of the Week: Levetiracetam Rapid IV Push
Special Guest: Olivia Morgan, PharmD, BCCCP, BCGP
I’m joined by Olivia Morgan to discuss her first author 2020 Neurocritical Care article entitled “Safety and Tolerability of Rapid Administration Undiluted Levetiracetam.”
We review previous administration techniques and discussing how this study came to be before highlighting all the findings from this Trial of the Week. Then we discuss how the protocol has changed since this study, administering other ASM via rapid IV push, and much, much more.
Reference list: https://pharmacytodose.files.wordpress.com/2024/03/keppra-rapid-ivp-references.pdf
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Glycemic Control in the Critically Ill: Part I
Special Guest: Traci Grucz, PharmD, BCCCP @tmgrucz
04:50 – ICU hyperglycemia mechanism
09:52 – Background/landmark research
27:00 – Current recommendations
30:25 – Hyperglycemia and hypoglycemia tips/tricks
46:30 – Treatment considerations
54:50 – Take-home points
Reference List: https://pharmacytodose.files.wordpress.com/2024/02/glycemic-control-in-the-icu-part-i-references.pdf
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Literature Review Series
September 2023
Special Guests: Garrett Terhune, PharmD
Caroline Blankemeier, PharmD
04:35 – Featured Articles
32:28 – Pulm
38:35 – PADIS
46:50 – Neuro
53:40 – Trauma
62:00 – PharmD
68:10 – Grab Bag
Reference List: https://pharmacytodose.files.wordpress.com/2024/02/september-lrs-2023-references.pdf
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Immunotherapy Part II
Special Guest: Matt McKenzie, PharmD, BCCCP @mgm485
04:40 – What is and when do we use immunotherapy?
09:00 – CAR-T cell therapy
15:20 – Standard ICU work-up
21:00 – Cytokine release syndrome (CRS)
35:00 – Immune effector cell-associated neurotoxicity syndrome (ICANS)
51:00 – Immune checkpoint inhibitors
64:30 – Summary and take-home points
Reference List: https://pharmacytodose.files.wordpress.com/2024/02/immunotherapy-part-ii-references.pdf
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Burnout and Well-being
Special Guest: Brent Reed, PharmD, MS, PhD Candidate
07:25 – How did we get here?
09:05 – Defining and drivers of burnout
18:45 – Is it too late if we're already experiencing?
20:15 – Relationship between well-being and burnout
22:00 – Work:life balance
29:00 – Precepting and teaching
35:25 – Foundation of burnout prevention
38:30 – 5 step process for work design change
50:50 – Being proactive and short-/long-term fixes
Reference List: https://pharmacytodose.files.wordpress.com/2024/02/burnout-and-well-being-references.pdf
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Literature Review Series
August 2023
Special Guests: Katie Rogers, PharmD
Eric Johnston, PharmD
04:35 – Featured Articles
39:00 – Sepsis
47:35 – Potpourri
52:45 – Infectious Diseases
61:45 – PharmD
68:15 – Grab Bag
Reference List: https://pharmacytodose.files.wordpress.com/2024/01/august-lrs-2023-references.pdf
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2024 SCCM Congress Recap
Special Guest: Anthony Hawkins, PharmD, FCCM, BCCCP
Conference correspondent Anthony Hawkins returns to recap all the happenings from the 2024 SCCM Congress. We review Phoenix, likes and dislikes from the Convention Center, session highlights, exhibit hall review, favorite session titles, PharmD award winners, and much, more.
2024 SCCM Congress website: https://congress2024.sccm.org
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2024 SCCM Congress: Tuesday
Special Guests: Karen Berger, PharmD, FASHP, FCCM, BCCCP, BCPS
Melanie Smith Condeni, PharmD, FCCM, BCPS, BCCCP
Julie Farrar, PharmD, BCCCP
Lama Nazer, PharmD, BCPS
Joanna Stollings, PharmD, FCCP, FCCM, BCPS, BCCCP
Andy Webb, PharmD, BCCCP
03:05: Star Research Presentation: “Effect of Antipsychotics on Agitation in ICU Delirium: Secondary Analysis of a Randomized Trial” featuring Joanna Stollings
10:43: Star Research Presentations: “Procalcitonin and Antimicrobial Utilization in Critically Ill Cancer Patients with Sepsis (PRO-CAN)” & “Diagnostic and Prognostic Value of Procalcitonin in Critically Ill Cancer Patients with Sepsis” featuring Lama Nazer
25:32: Clinical Pharmacy and Pharmacology (CPP) Year in Review presenter and moderator roundtable discussion featuring Karen Berger, Melanie Smith Condeni, Julie Farrar, and Andy Webb
2024 SCCM Congress website: https://congress2024.sccm.org
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2024 SCCM Congress: Monday
Special Guests: Caitlin Brown, PharmD, BCCCP, FCCM
Marilyn Bulloch, PharmD, BCPS, FCCM
Kayla Kotch, PharmD, BCCCP
02:55: Marilyn Bulloch discusses her role and experience as a 2024 SCCM Congress co-chair
28:30: Star Research Presentation: “Impact of Early Initiation of Phenobarbital for Alcohol Withdrawal Syndrome in the Critically Ill” featuring Kayla Kotch
39:00: Star Research Presentation: “A Multicenter Study of Pulmonary Embolism Patients Treated with Reduced- or Full-Dose Alteplase” featuring Caitlin Brown
2024 SCCM Congress website: https://congress2024.sccm.org
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2024 SCCM Congress: Sunday
Special Guests: Judi Jacobi, PharmD, BCCCP, MCCM
Blake Robbins, PharmD, MBA, BCCCP
02:45: Quick review of the happenings on Sunday, January 21st from 2024 SCCM Congress
07:20: Star Research Presentation: “Standard vs. Augmented Corticosteroid Dosing in Mechanically Ventilated Patients due to COVID-19” featuring Blake Robbins
22:05: Discussion about the SCCM Glycemic Control in the ICU featuring Judi Jacobi
Glycemic control guidelines: https://journals.lww.com/ccmjournal/fulltext/9900/society_of_critical_care_medicine_guidelines_on.277.aspx
Star research presentation: https://journals.lww.com/ccmjournal/pages/articleviewer.aspx?year=2024&issue=01001&article=00030&type=Fulltext
PROPHY-VAP: https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(23)00471-X/fulltext
2024 SCCM Congress website: https://congress2024.sccm.org
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2024 SCCM Congress: Saturday
The episode starts out with a preview of the 2024 SCCM Congress schedule as the conference starts Sunday, January 21 in Phoenix, AZ
11:25: Then I highlight 3 presentations with Pharmacist speakers from the SCCM Digital Congress
Fill the Tank or Squeeze the Pipes? Fluid Administration Over Early Vasopressor Therapy for the Management of Shock with Olivia Marchionda, PharmD, BCCCP
Anticoagulation Considerations in Critically Ill Oncology Patients with Heather May, PharmD, MSc, BCCCP, FCCM
Pharmacologic Agents Used in the ICU for Palliation of Symptoms: What’s New? With Nicole Palm, PharmD, BCCCP, FCCM
2024 SCCM Congress website: https://congress2024.sccm.org
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ACORN: Rapid Reaction
Special Guests: Michael Behal, PharmD, BCCCP
Joanna Stollings, PharmD, FCCP, FCCM, BCPS, BCCCP
Michael Behal joins me to review the recently published ACORN trial from JAMA. We highlight the background of antibiotic-associated AKI, review the trial methodology and results, dive into the supplement and talk about duration of treatment, empiric v. targeted treatment, have definitively answered this question or not, and much more.
Joanna Stollings makes a special appearance highlighting her experience on the research group while also discussing the logistics of this innovative trial design.
Reference List: https://pharmacytodose.files.wordpress.com/2024/01/acorn-rapid-reaction-references.pdf
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Pharmacy to Eat: Food Recommendations and Life Update
HAPPY THANKSGIVING!
03:19 – Indianapolis: Nick Peters
04:50 – Boston: Grace Erdman
05:55 – New Haven: Steve Lemieux and Kelly Oldziej
08:30 – Buffalo: Nick Servati
10:33 – New York: Karen Berger and Peter Nikolos
12:58 – Philadelphia: Ashley Barlow, Brooke Barlow, Sara Groome, Alyssa Meester, and Todd Miano
19:31 – Maryland: Mojdeh Heavner and Amy Yeung
21:38 – Charleston: Melanie Smith Condeni
24:07 – Memphis: Morgan Jones
26:18 – Cincinnati: Chris Droege
30:00 – Chicago: Matt Rubertus
31:35 – Detroit: Zach Smith
32:57 – Texas: Josiah Smith and Matt Wanat
36:25 – Europe: Philip Jacobson
38:12 – Favorite meals: Brian Gilbert and Haley Peters
41:02 – Life update
https://pharmacytodose.com/2023/11/23/pharmacy-to-eat-food-recommendations/
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