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Howie and Harlan are joined by Atheendar Venkataramani, a physician, health economist, and director of the Perelman School of Medicine’s Opportunity for Health Lab, to discuss the powerful role of economic opportunity in population health outcomes. Harlan reports on two studies where treatments’ unexpected benefits leapt ahead of understanding why they work. Howie reflects on the business model of the pharma industry and the market reaction to anti-obesity drugs.
Links:
Opportunity for Health | Home
“College Affirmative Action Bans and Smoking and Alcohol Use among Underrepresented Minority Adolescents in the United States: A Difference-in-differences Study”
“Police Killings and Their Spillover Effects on the Mental Health of Black Americans: A Population-based, Quasi-experimental Study”
“Officer-Involved Killings of Unarmed Black People and Racial Disparities in Sleep Health“
Behavioral Risk Factor Surveillance System | Home
“Building Black Wealth — The Role of Health Systems in Closing the Gap“
KFF | Understanding Mergers Between Hospitals and Health Systems in Different Markets
“In Hospitals, Affordable Housing Gets the Long-Term Investor It Needs”
American College of Cardiology 73rd Annual Scientific Session & Expo
“Semaglutide in Patients with Obesity-Related Heart Failure and Type 2 Diabetes“
“Coronary sinus reducer for the treatment of refractory angina (ORBITA-COSMIC): a randomised, placebo-controlled trial”
“A Placebo-Controlled Trial of PCI for Stable Angina“
“Trial of Lixisenatide in Early Parkinson’s Disease“
“The Cream of The Crop: 5 Biotechs That Outrank Most Stocks”
“How High Can Eli Lilly Stock Go? $1,000 A Share, One Analyst Says”
Learn more about the MBA for Executives program at Yale SOM.
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Howie and Harlan are joined by Kate McEvoy, executive director of the National Association of Medicaid Directors, to discuss the programs’ underappreciated advances in holistically addressing health, housing, and food security. Reflecting on the upcoming election, Harlan notes that facts matter, whether in medicine or politics. Howie reports on the dangers of glyoxylic acid in hair straightening products.
Links:
“Trump Leads Biden in Six of Seven Swing States, WSJ Poll Finds”
“Takeover: Hitler’s Final Rise to Power”
“The Forgotten History of Hitler’s Establishment Enablers”
The Future of Health Policy in a Partisan United States
“Netflix blockbuster ‘3 Body Problem’ divides opinion and sparks nationalist anger in China”
“The Future of American Democracy Depends on Improving U.S. Health”
Wikipedia | Glyoxylic acid
Kidney Injury and Hair-Straightening Products Containing Glyoxylic Acid
American Cancer Society | Formaldehyde and Cancer Risk
Kaiser Family Foundation | 10 Things to Know About the Unwinding of the Medicaid Continuous Enrollment Provision
Kaiser Family Foundation | Medicaid Postpartum Coverage Extension Tracker
CMS | NHE Fact Sheet
Moral Injuries in Healthcare Workers: What Causes Them and What to Do About Them?
NCDHHS | Healthy Opportunities Pilots
HealthTech4Medicaid | About
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Saknas det avsnitt?
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Howie and Harlan are joined by Margo Harrison, an OB-GYN and femtech entrepreneur, to discuss how innovative solutions to women’s health problems offer deeper understanding and expanded choices. Harlan and Howie each offer a caveat emptor for lightly regulated, unproven supplements and treatments such as Prevagen and hydration spas.
Links:
“Prevagen Review: A Word of Caution”
“Prevagen®: Analysis of Clinical Evidence and Its Designation as a ‘#1 Pharmacist Recommended Brand’”
“NY Jury Rules Some Claims About Prevagen Are Misleading”
“Effects of a Supplement Containing Apoaequorin on Verbal Learning in Older Adults in the Community”
Mate Fertility: Home
Dahlia Ventures
Margo Harrison, MD: Assistant Adjoint Professor, OB-GYN-Basic Repro Science
Margo Harrison: LinkedIn
“Use of Cesarean Birth at Mizan Tepi University Teaching Hospital, Mizan Aman, Ethiopia”
“Postpartum Contraceptive Use Among Denver-Based Adolescents and Young Adults: Association with Subsequent Repeat Delivery”
“Warnings grow about risky IV drips and injections at unregulated med spas”
“FDA highlights concerns with compounding of drug products by medical offices and clinics under insanitary conditions”
“Drip bar: Should you get an IV on demand?”
“Are Your Therapies FDA Compliant?”
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Howie and Harlan are joined by Yale health economist Zack Cooper to discuss his work on surprise medical bills and the impact of high healthcare costs on households, wages, and the economy. Harlan reports on Hippocratic AI’s efforts to develop AI nurses. Howie looks at the global effort to eradicate tuberculosis.
Links:
“Hippocratic AI banks $53M backed by General Catalyst, a16z, Memorial Hermann, UHS and other health systems”
“Polaris: A Safety-focused LLM Constellation Architecture for Healthcare”
Yale | Eli Whitney Students Program
Touching the Dragon: And Other Techniques for Surviving Life’s Wars
The Price Ain’t Right? Hospital Prices and Health Spending on the Privately Insured
“Costs Can Go Up Fast When E.R. Is in Network but the Doctors Are Not”
“Bankrupt Envision Healthcare approved to split in two, cut debt”
“The Company Behind Many Surprise Emergency Room Bills”
Surprise! Out-of-Network Billing for Emergency Care in the United States
“Medical LLM developer Hippocratic AI gets $53M at $500 valuation”
The Breakthrough of Large Language Models Release for Medical Applications: 1-Year Timeline and Perspectives
World Health Organization | World Tuberculosis Day
Partners In Health | Tuberculosis
“WHO urges investments for the scale up of tuberculosis screening and preventive treatment”
“The latest twist in John Green’s anti-tuberculosis story: working with governments”
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Howie and Harlan are joined by Robert Alpern, a Yale nephrologist and the former dean of the Yale School of Medicine, to discuss the importance of a fiscal base for enabling a medical school to deliver top-quality training, research, and clinical care. Harlan asks whether widespread norovirus is a reason to call it quits on shaking hands. Howie reports on a study of the increased mortality among those with ADHD.
“Nephrologist Robert Alpern Named Dean of Yale School of Medicine”
“UT Southwestern: From Army” Shacks to Research Elites”
“National Clinician Scholars Program”
“A ‘bittersweet’ end: Historic merger creates one of the nation’s largest hospitals”
“Yale New Haven Health: Smilow Cancer Hospital”
“Alpern will not seek a fourth term as School of Medicine dean”
“Alpern to Step Down After Current Term as Dean”
“Cleveland Clinic: Norovirus”
“State of Affairs: March 12: Flu, measles, norovirus, and interesting Pew results”
“Norovirus has entered the chat”
“ADHD Pharmacotherapy and Mortality in Individuals With ADHD”
“Overdiagnosis of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents”
“Racial Disparities in Diagnosis of Attention-Deficit/Hyperactivity Disorder in a US National Birth Cohort”
“Longitudinal associations between digital media use and ADHD symptoms in children and adolescents: a systematic literature review”
Learn more about the MBA for Executives program at Yale SOM.
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Howie and Harlan are joined by Robert Rohrbaugh, professor of psychiatry and deputy dean for professionalism and leadership at the Yale School of Medicine, to discuss his work training doctors in antiracist practices and ensuring the wellbeing of clinicians during the pandemic. Harlan reports on the problematic history of medical journals promoting eugenics; Howie highlights a cyberattack that has paralyzed Change Healthcare, the country’s largest payments processing hub.
Links:
Antiracist Documentation Practices — Shaping Clinical Encounters and Decision Making
American Psychological Association | Implicit Bias
“YSM Ranks #1 in U.S. News Survey for Psychiatry”
COVID-19 Traumatic Disaster Appraisal and Stress Symptoms Among Health Care Workers
Application of Artificial Intelligence on Psychological Interventions and Diagnosis: An Overview
Is AI the Future of Mental Healthcare?
ChatGPT outperforms humans in emotional awareness evaluations
“Ridding the Race of His Defective Blood” — Eugenics in the Journal, 1906–1948
Problems Underlying Public Hospital Administration
Wikipedia | Public Hospital
Eugenics and Involuntary Sterilization: 1907–2015
“Cyberattack Paralyzes the Largest U.S. Health Care Payment System”
“Physicians beg for relief amid Change Healthcare payment crisis”
“Court Rejects Vertical Merger Challenge Brought by DOJ”
“Aledade Takes Steps to Support Independent Primary Care Partners in Wake of Change Healthcare CyberAttack”
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Howie and Harlan discuss health and healthcare headlines, including a cheating scandal that has led to the invalidation of hundreds of scores from Nepal on the U.S. Medical Licensing Examination, the problem of research that never sees the light of day, new anti-obesity medications, and Florida’s unorthodox approach to measles.
Links:
Standardized Testing
“Cheated out of the American Dream”
“MCAT scores and medical school success: Do they correlate?”
”Reducing Medical School Admissions Disparities in an Era of Legal Restrictions: Adjusting for Applicant Socioeconomic Disadvantage”
“Medical School Admissions — A Movable Barrier to Ending Health Care Disparities?”
“Yale Reinstates Standardized Test Score Requirement For Admissions”
“New SAT Data Highlights the Deep Inequality at the Heart of American Education”
Research at Universities
Good Science Project: Stuart Buck
“Why Are We Screwing Over Researchers Who Make Innovative Discoveries?”
Intellectual Property: Ownership and Protection in a University Setting
Measles in Florida
“From COVID-19 to Measles, Florida’s War on Public Health”
CDC: About Measles
“Additional measles case reported at Florida elementary school as lawmaker urges public health emergency”
Obesity Drugs
“Heard on the Street: Viking Therapeutics Invades Eli Lilly’s Obesity Territory”
Unreleased Research Data
“The Ghost Research Haunting Nordic Medical Trials”
“Publication of NIH funded trials registered in ClinicalTrials.gov: cross sectional analysis”
Harlan Krumholz: “What have we learnt from Vioxx?”
A Transformative Gift
“$1 Billion Donation Will Provide Free Tuition at a Bronx Medical School”
IVF in Alabama
The Alabama Supreme Court’s Ruling
“Florida Suspends Bill to Protect ‘Unborn Child’ After I.V.F. Ruling”
Johns Hopkins Bloomberg School of Public Health: The Alabama Supreme Court’s Ruling on Frozen Embryos
Faculty for Yale
Faculty for Yale
“The Need For Institutional Neutrality At Universities”
“Yale faculty sign letter addressed to Yale’s future president, affirms commitment to social justice”
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Howie and Harlan are joined by Lucila Ohno-Machado, the Yale School of Medicine’s deputy dean for biomedical informatics. She explains how expanding use of data science, informatics, AI, and technology could enable doctors to spend more time with patients. Harlan celebrates mentorship while marking the death of Irwin Birnbaum, a mentor to many in his time as COO of the Yale Medical School and long after retiring. Howie discusses the mixed evidence from a study on vaping as a tool for helping cigarette smokers quit.
Links:
“Lucila Ohno-Machado, MD, PhD, MBA, Will Lead Biomedical Informatics and Data Science”
“Lucila Ohno-Machado: Yale Medicine Profile”
“Halıcıoğlu Data Science Center”
“2024 AI in Medicine Symposium at Yale School of Medicine”
“Doctors Vs. ChatGPT: Which Is More Empathetic?”
“Irwin M. Birnbaum Obituary”
“What is a mentor?”
“A Randomized Trial of E-Cigarettes versus Nicotine-Replacement Therapy”
“Episode 78, Health and Veritas: Elizabeth Arleo: Advice for Working Mothers from a Women’s Health Specialist”
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Howie and Harlan are joined by Farzad Mostashari, co-founder and CEO of Aledade, an "accountable care organization" that seeks to align patient-provider incentives so doctors can make a profit by prioritizing preventive care. Harlan discusses a study suggesting that physical exercise may be protective from severe COVID. Howie highlights the introduction of Apple’s VR headset and the importance of further study to understand the technology’s capacity to “rewire” our brains.
Links:
"Aledade: Home Page"
“Farzad Mostashari: Man On A Digital Mission”
“Health Reform and Physician-Led Accountable Care:The Paradox of Primary Care Physician Leadership”
“Staggering Rise in Catheter Bills Suggests Medicare Scam”
“Accountable Care Organizations (ACOs): General Information”
“Novid: Definition”
“Prepandemic Physical Activity and Risk of COVID-19 Diagnosis and Hospitalization in Older Adults”
“VR risks for kids and teens”
“2024 Outlook: Despite hurdles, stakeholders bullish on VR in behavioral health”
“AI therapy and ICU training: A first look at health apps for Apple Vision Pro”
“Effects of an Immersive Virtual Reality Intervention on Pain and Anxiety Among Pediatric Patients Undergoing Venipuncture”
“Virtual Reality for Management of Pain in Hospitalized Patients: Results of a Controlled Trial”
“Virtual Reality Reduces Pain in Laboring Women: A Randomized Controlled Trial”
“Apple Vision Pro”
Learn more about the MBA for Executives program at Yale SOM.
Learn more about the Pozen-Commonwealth Fund Fellowship in Health Equity Leadership.
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Howie and Harlan are joined by Christopher O’Connor, CEO of Yale New Haven Health, to discuss his career path and his experience leading hospitals through Hurricane Katrina and COVID-19. Harlan reports on promising AI tools for taking clinical notes; Howie looks at the financial headwinds facing the companies offering Medicare Advantage plans.
Links:
AI Notetaking
“OpenAI-backed healthcare AI startup raises $70 million Series B”
“Burnout Related to Electronic Health Record Use in Primary Care”
“Ambient Artificial Intelligence Scribes to Alleviate the Burden of Clinical Documentation”
“Medical AI scribe startup Nabla rolling out tool to the Permanente Medical Group docs in Northern California”
“Ambience Healthcare reels in $70M for generative AI tools to battle clinician burnout”
Hospital Leadership
"After 20 Years and $16,000, A Hospital Debt Is Canceled"
Harlan Krumholz: “Out‐of‐Pocket Annual Health Expenditures and Financial Toxicity From Healthcare Costs in Patients With Heart Failure in the United States”
"Connecticut hospitals face record financial losses"
"Update on Effect of Hurricane Katrina on Ochsner Clinic Foundation, LA"
"YNHH and Hospital of Saint Raphael become one"
Medicare Advantage
“Humana slashes profit predictions amid soaring Medicare Advantage costs”
HHS: “Biden-Harris Administration is Strengthening Medicare; Protecting and Serving America’s Seniors”
"Cano Health’s downfall offers a warning for Medicare Advantage"
CMS: Risk Adjustment
Learn more about the MBA for Executives program at Yale SOM.Email Howie and Harlan comments or questions.
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Howie and Harlan are joined by Manisha Juthani, a Yale infectious disease specialist and commissioner of the Connecticut Department of Public Health. They discuss her research, including a study casting doubt on the use of cranberries to prevent urinary tract infection, and her priorities for Connecticut. Harlan reports on a wave of study retractions from the Dana-Farber Cancer Institute; Howie reflects on the progress made toward eradicating Guinea worm and malaria.
Links:
Retractions from the Dana-Farber Cancer Institute
“Dana-Farber Cancer Institute Researchers Accused of Manipulating Data”
“Top Cancer Center Seeks to Retract or Correct Dozens of Studies”
Pubpeer: The Online Journal Club
“‘A lot of it is sloppiness’: the biologist who finds flaws in scientific papers”
Manisha Juthani
“An Outbreak of Domestically Acquired Typhoid Fever in Queens, NY”
Manisha Juthani: “Effect of Cranberry Capsules on Bacteriuria Plus Pyuria Among Older Women in Nursing Homes—A Randomized Clinical Trial”
“Reduction of Bacteriuria and Pyuria After Ingestion of Cranberry Juice”
Yale School of Medicine Medical Grand Rounds: “Debunking a myth: cranberry products for UTI prevention”
Connecticut Department of Public Health
Connecticut Department of Public Health: About the Commissioner
Connecticut Department of Public Health: Statistics and Research
“Court: CT can keep law that ends religious exemptions for vaccines”
“Congenital syphilis cases in the U.S. have skyrocketed, CDC says”
Eradicating Parasites
“Jimmy Carter took on the awful Guinea worm when no one else would—and he triumphed”
“Cape Verde reaches malaria-free milestone”
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Howie and Harlan are joined by Yale SOM alum Claudine Litman, a designer and the director of Yale‘s Center for Outcomes Research & Evaluation, to talk about using the tools of design to build more effective healthcare spaces and processes. Harlan looks at seven charts illustrating the state of healthcare in 2023; Howie reports on the FDA reprimanding a drug company for misleading advertising.
Links:
Healthcare in 2023
"Seven Charts That Sum Up U.S. Healthcare In 2023"
Designing Better Healthcare
Yale School of Medicine:Center for Outcomes Research & Evaluation
Design for Care: Innovating Healthcare Experience
This Is Service Design Doing: Applying Service Design Thinking in the Real World
The Design of Business: Why Design Thinking is the Next Competitive Advantage
Misleading Advertising
"FDA scolds Novartis over a misleading TV ad for a breast cancer treatment"
Public Law 87-781, 76 STAT 780
FDA: Letter to PharmD
Direct-to-Consumer Prescription Drug Advertisements: Presentation of the Major Statement in a Clear, Conspicuous, and Neutral Manner in Advertisements in Television and Radio Format Final Rule Questions and Answers Guidance for Industry
NIH: Direct-to-Consumer Pharmaceutical Advertising
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Howie and Harlan are joined by Reshma Ramachandran, a Yale family physician and co-director of Yale Collaboration for Regulatory Rigor, Integrity, and Transparency. They discuss the potential ramifications for healthcare regulation if the Supreme Court overturns the Chevron decision requiring judges to defer to federal agencies. Harlan looks at surveys suggesting an erosion of trust in medicine; Howie reports on the growing measles outbreak.
LInks:
Trust in Healthcare
“Nurses First, Doctors Distant Second in Healthcare Provider Ratings”
“KFF Health Tracking Poll: Health Care Issues Emerge as Important Topics on 2024 Campaign Trail, Plus Concerns Loom Large Around Medicaid Unwinding”
Reshma Ramachandran
“What is Ayurveda?”
“On Writ of Certiorari to the United States Court of Appeals for the First Circuit: BRIEF OF DR. RESHMA RAMACHANDRAN AND DR. JOSEPH S. ROSS AS AMICI CURIAE IN SUPPORT OF RESPONDENTS”
“Agencies’ Power Under Scrutiny in Supreme Court Arguments”
“Supreme Court could reel in power of federal agencies with dual fights over fishing rule”
“Case brought to Supreme Court by herring fishermen may gut federal rulemaking power”
Reshma Ramachandran: “Medical Product Industry Ties to Patient Advocacy Organizations’ Executive Leadership”
Reshma Ramachandran: “Do Advocacy Groups Always Put Patient Interests First?”
“Citizens United Explained”
The Measles Outbreak
“Another person infected with measles at a Northeast daycare as Philadelphia outbreaks grows to nine cases”
“DC Cautions Residents of a Potential Measles Exposure”
CDC: Measles Cases and Outbreaks
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Howie and Harlan discuss the winter wave of COVID-19 and Howie’s experience with the Novovax vaccine, report on potential side effects of the next-generation weight-loss drugs, and unpack the economics of Florida’s plan to import drugs from Canada.
Links:
Sid Wolfe
“Sidney M. Wolfe, Scourge of the Pharmaceutical Industry, Dies at 86”
COVID-19
“Florida surgeon general calls for halt on mRNA covid vaccines, citing debunked claim”
"Safety and Adverse Events Related to Inactivated COVID-19 Vaccines and Novavax;a Systematic Review"
“Paul Offit Debunks Florida Surgeon General's Anti-Vax Warning”
“Does Novavax's Covid vaccine cause fewer side effects?”
“SOTP: State-of-the-Pandemic: The pandemic's 2nd biggest wave of infections and what the JN.1 variant is telling us”
“Deaths induced by compassionate use of hydroxychloroquine during the first COVID-19 wave: an estimate”
Weight-Loss Drugs
“FDA looking into reports of hair loss, suicidal thoughts in people using popular drugs for diabetes and weight loss”
“Semaglutide and risk of suicidal ideations”
“January - March 2023 | Potential Signals of Serious Risks/New Safety Information Identified by the FDA Adverse Event Reporting System (FAERS)”
Elevance and Medicare
“Elevance sues HHS over Medicare Advantage star ratings”
“How the Tukey Method Could Impact Star Ratings”
TriNetX: Explore. Discover. Connect
Large Language Models
“Diagnostic Accuracy of a Large Language Model in Pediatric Case Studies”
“Artificial Intelligence and Machine Learning in Clinical Medicine, 2023”
Drug Imports
“US FDA to allow Florida to import cheaper drugs from Canada”
“FDA approves Florida's request to import cheaper drugs from Canada”
“Price-Fixing Case Reveals Vulnerability of Generic Drug Policies”
June Jackson Christmas
“June Jackson Christmas, Pioneering Psychiatrist, Dies at 99”
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Howie and Harlan are joined by Julie Ann Sosa, chair of the University of California San Francisco department of surgery. She reports on new approaches to treating thyroid nodules, addressing sexual harassment within the medical profession, and supporting personal and professional success for doctors caring for elderly parents. Harlan and Howie discuss the upswing in COVID-19 cases and research on whether the benefits of exercise could be delivered by a pill.
Links:
Prospects for Faculty in the Arts and Sciences: A Study of Factors Affecting Demand and Supply, 1987 to 2012
Trends in Thyroid Cancer Incidence and Mortality in the United States, 1974-2013
Active Surveillance Versus Thyroid Surgery for Differentiated Thyroid Cancer: A Systematic Review
The importance of surgeon experience for clinical and economic outcomes from thyroidectomy.
Addressing Eldercare to Promote Gender Equity in Academic Medicine
Sexual harassment, sexual assault and rape by colleagues in the surgical workforce, and how women and men are living different realities: observational study using NHS population-derived weights
CDC | COVID Data Tracker
CDC | Stay Up to Date with COVID-19 Vaccines
"Could exercise pills help create a healthier society?"
Safety and Efficacy of Plasma Transfusion From Exercise-trained Donors in Patients With Early Alzheimer's Disease (ExPlas)
"Latest data shows millions of eligible Americans have been disenrolled from Medicaid"
KFF | Medicaid Enrollment and Unwinding Tracker
National Bureau of Economic Research | Oregon Health Insurance Experiment
"More than 13 million people lost Medicaid coverage this year, with Texas an epicenter of the 'unwinding'"
Learn more about the MBA for Executives program at Yale SOM.
Learn more about the Pozen-Commonwealth Fund Fellowship in Health Equity Leadership.
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Howie and Harlan are joined by Eric Winer, director of the Yale Cancer Center and president of Yale's Smilow Cancer Hospital. They discuss his career, his personal experiences with hemophilia and HIV, and the state of breast cancer treatment. Harlan reports on the retraction of a high-profile study on the effect of hearing aids on dementia; Howie provides some good news from an annual report on health expenditures in the U.S.
Links:
A Retracted Study
“Retraction—Association between hearing aid use and all-cause and cause-specific dementia: an analysis of the UK Biobank cohort”
The original study: “RETRACTED: Association between hearing aid use and all-cause and cause-specific dementia: an analysis of the UK Biobank cohort”
Eric Winer
Dana Farber Cancer Institute
Wikipedia: Alexei Nikolaevich, Tsarevich of Russia
Wikipedia: Nicholas and Alexandra
CDC: What is Hemophilia?
“Bayer division 'knowingly sold' HIV-infected protein”
Eric Winer: 2023 ASCO Presidential Address, “Partnering With Patients: The Cornerstone of Clinical Care and Research”
Eric Winer: “Breast Cancer Treatment: A Review”
"‘I’m Scared to Death.’ Behind the Shortage Keeping Cancer Patients From Chemo"
National Health Expenditures
CDC: National Health Expenditure Data
Read an unedited transcript of this episode.Learn more about the MBA for Executives program at Yale SOM.
Learn more about the Pozen-Commonwealth Fund Fellowship in Health Equity Leadership.
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Howie and Harlan are joined by Tina Loarte-Rodríguez, associate director, health equity measures, at Yale’s Center for Outcomes Research & Evaluation and the author of Latinas in Nursing: Stories of Determination, Inspiration, and Trust. And Howie and Harlan discuss the clinical and economic dimensions of two newly approved CRISPR-based treatments for sickle cell disease.
Links:
Tina Loarte-Rodríguez
Tina Loarte-Rodríguez: Latinas in Nursing: Stories of Determination, Inspiration, and Trust
Center for Outcomes Research & Evaluation (CORE)
Center for Outcomes Research & Evaluation: Quality Measurement
“Sociodemographic Disparities in Queue Jumping for Emergency Department Care”
New Treatments for Sickle Cell Disease
“In historic decision, FDA approves a CRISPR-based medicine for treatment of sickle cell disease”
“F.D.A. Approves Sickle Cell Treatments, Including One That Uses CRISPR”
The Nobel Prize in Chemistry 2020
Yale New Haven Health: Sickle Cell Program
“Milestones in Sickle Cell Research and Care”
Bluebird Bio
Yahoo Finance: Bluebird Bio, Inc.
“Tough road ahead for Bluebird Bio despite FDA approval for sickle cell therapy”
“Harlan M. Krumholz Named Next Editor-in-Chief of JACC”
Read an unedited transcript of this episode.Learn more about the MBA for Executives program at Yale SOM.
Learn more about the Pozen-Commonwealth Fund Fellowship in Health Equity Leadership.
Email Howie and Harlan comments or questions.
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Howie and Harlan are joined by Tara Sanft, chief patient experience officer at Yale’s Smilow Cancer Hospital and director of the Survivorship Program at the Yale Cancer Center. Harlan reports on his study of patients with long-lasting symptoms after the COVID-19 vaccine; Howie reflects on the historic decline in cigarette smoking in the United States.
Links:
Post-Vaccination Syndrome
Harlan Krumholz: “Post-Vaccination Syndrome: A Descriptive Analysis of Reported Symptoms and Patient Experiences After Covid-19 Immunization”
Patient Experience and Cancer Survivorship
Tara Sanft: “Rekindling Joy in Medicine Through Thoughtful Communication: A Practical Guide”
“Impact of the COVID-19 Pandemic on Breast Cancer Screening and Operative Treatment”
“Impact of Financial Burden of Cancer on Survivors’ Quality of Life”
Yale Medicine: Cancer Survivorship
The White House: Cancer Moonshot
The Decline in Smoking
“Trends in US Adult Smoking Prevalence, 2011 to 2022”
"BAT Writing Off £25 Billion on US Cigarettes, Shares Fall"
"Vaping Declines Among High School Students, Survey Shows"
"Why Philip Morris Stock Is Falling After Earnings Beat Expectations"
"Big Tobacco Rethinks Its Smoking Addiction"
National Cancer Institute: Cancer Stat Facts: Common Cancer Sites
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Howie and Harlan are joined by Stephanie Sudikoff, an expert on using simulation to train healthcare professionals, to discuss her new venture working to expand treatment for neonatal jaundice and how simulating procedures can assist in quality control and ongoing training. They also look at new developments in AI in radiology and the economics of a powerful treatment for inflammation.
Links:
AI and Radiology
“Imaging AI hogs the spotlight at RSNA, with debuts from GE, Siemens, Philips”
“Accuracy of ChatGPT, Google Bard, and Microsoft Bing for Simplifying Radiology Reports”
“Characterizing the Clinical Adoption of Medical AI Devices through U.S. Insurance Claims”
“Kim Kardashian Got a Full Body Scan, Why Medical Experts are Concerned”
“Design goal: Photon Counting CT engineered with Deep Silicon technology to enable advanced CT Imaging”
Heart Flow: Revolutionizing Precision Heart Care
Neonatal Jaundice and Medical Simulation
Little Sparrows Technologies: Big Ideas for Little Babies
Stephanie Sudikoff: “Variability in quality of chest compressions provided during simulated cardiac arrest across nine pediatric institutions”
“‘The Damar Effect’—the nationwide backorder on a lifesaving machine and the 620% increase in CPR”
Stephanie Sudikoff: “An Approach to Confederate Training Within the Context of Simulation-Based Research”
"Assessing the quality of primary healthcare in seven Chinese provinces with unannounced standardised patients: protocol of a cross-sectional survey"
The Economics of Dupixent
“Sanofi, Regeneron say Dupixent succeeds in another late-stage COPD study, setting up filing for FDA approval”
“With new trial data, a blockbuster therapy from Sanofi, Regeneron could find an even bigger market”
“A Drug for Itchy Dogs Costs $1,200. Why Is the Human Equivalent $43,000?”
“Dupilumab for COPD with Type 2 Inflammation Indicated by Eosinophil Counts”
Regeneron: “Dupixent ® (Dupilumab) significantly reduced COPD exacerbations in second trial”
“HHS Selects the First Drugs for Medicare Drug Price Negotiation”
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Howie and Harlan are joined by Jerold Mande, a nutrition expert who has served in the FDA, where he led the graphic design of the Nutrition Facts label, and the USDA. Harlan reports on promising new therapies for sickle cell disease, high cholesterol, and hypertension; Howie reflects on the Thanksgiving holiday and the contributions of former First Lady Rosalynn Carter, who died this week.
Links:
New Therapies
“Sickle-Cell Treatment Created With Gene Editing Wins U.K. Approval”
“Updated data show long-term benefits of CRISPR treatment for sickle cell, beta thalassemia”
“A Randomized, Double-Blind, Dose-Ranging Study of Zilebesiran in Patients With Mild-to-Moderate Hypertension—KARDIA-1”
“Effects of Intensive Blood Pressure Lowering Treatment in Reducing Risk of Cardiovascular Events —ESPRIT”
“VERVE-101: CRISPR-Based Gene Editing Therapy Shows Promise in Reducing LDL-C and PCSK9 Levels in Patients With HeFH”
Food and Health
“An Epidemic of Chronic Illness Is Killing Us Too Soon”
“Fatty Liver Was a Disease of the Old. Then Kids Started Getting Sick.”
“Bariatric Surgery at 16”
Nourish Science
USDA: Characteristics and Influential Factors of Food Deserts
Tufts University | Food Prices for Nutrition | Diet cost metrics for a better-fed world
Trouble With Erythritol
“Lead and Cadmium Could Be in Your Dark Chocolate”
“New evidence links ultra-processed foods with a range of health risks”
“Americans Are Addicted to 'Ultra-Processed' Foods, and It's Killing Us”
The End of Overeating: Taking Control of the Insatiable American Appetite
USDA: Learn how to eat healthy with MyPlate
Rosalynn Carter and Doing Good
“Altruism, Happiness, and Health: It’s Good to Be Good”
The Carter Center: Remarks of Former First Lady Rosalynn Carter at the National Press Club, Washington, D.C
“It’s Good To Be Good: 2014 Biennial Scientific Report On Health, Happiness, Longevity, And Helping Others”
“Rosalynn Carter, First Lady and a Political Partner, Dies at 96”
Read an unedited transcript of this episode.Learn more about the MBA for Executives program at Yale SOM.
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- Visa fler
